scholarly journals Intranasal lysine-aspirin administration decreases polyp volume in patients with aspirin-intolerant asthma

2007 ◽  
Vol 121 (12) ◽  
pp. 1156-1160 ◽  
Author(s):  
N Ogata ◽  
Y Darby ◽  
G Scadding
Keyword(s):  
Nitric Oxide ◽  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Nasal Polyp ◽  
Peak Expiratory Flow Rate ◽  
Peak Flow ◽  
Peak Flow Rate ◽  
Nasal Symptoms ◽  
Nasal Inspiratory Peak Flow ◽  
Before And After

AbstractIntroduction:Nasal polyposis associated with aspirin-intolerant asthma tends to be difficult to control, with frequent recurrences. We examined the effect of intranasal lysine-aspirin administration on resistant nasal polyps of asthmatic, aspirin-intolerant patients, when used in addition to routine therapy.Patients and methods:Thirteen patients with asthma and intolerance to aspirin were recruited. All but one had undergone numerous polypectomies and were uncontrolled on standard therapy with intranasal corticosteroids, leukotriene receptor antagonists and nasal douching. Aspirin treatment involved one drop (100 µl) of 30 mg/ml lysine-aspirin solution to each nostril, initially daily, increased every two or three days up to a maximal of 18 drops (54 mg lysine-aspirin) a day. Nasal symptoms, nitric oxide level, nasal inspiratory peak flow rate, peak expiratory flow rate and nasendoscopic grading were assessed prior to therapy and three months later. We also compared the change in endoscopic polyp scores during three months of lysine-aspirin administration with the changes which had occurred during the three months prior to administration (during which time other therapies had been identical).Results:Nasal blockage symptoms tended to decrease; other nasal symptoms were unchanged. Significant changes were seen in nasal inspiratory peak flow rate (103.3 ± 18.9 and 140.0 ± 16.7 l/min before and after aspirin, respectively; p = 0.014), but not in peak expiratory flow rate (438.7 ± 33.4 and 440.0 ± 28.4 l/min before and after aspirin, respectively; p = 0.700). Nasal nitric oxide levels rose significantly (in both sides, p = 0.028). Expired chest nitric oxide levels did not change. Nasal polyp scores on nasendoscopic examination were significantly reduced (right side, p = 0.027; left side, p = 0.018). Compared with the preceding three months, adding intranasal lysine-aspirin application had the effect on decreasing nasal polyp volume (right side, p = 0.031; left side, p = 0.016).Conclusion:This open study suggests that intranasal lysine-aspirin administration reduces nasal polyp volume in aspirin-intolerant patients, without any adverse affect on concomitant asthma. This was a preliminary study and should be followed by a placebo-controlled, double-blind trial.

Self monitoring of peak expiratory flow rate in asthma

1982 ◽  
Vol 20 (19) ◽  
pp. 73-74 ◽  
Keyword(s):  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Peak Flow ◽  
Forced Expiration ◽  
Deep Inspiration ◽  
Ventilatory Function ◽  
Self Monitoring ◽  
Expiratory Flow ◽  
Predicted Values

Peak Expiratory Flow Rate (PEF) is a simple and reproducible indicator of ventilatory function.1 It is the maximal airflow sustained for at least 10 msec during a forced expiration after deep inspiration. PEF is easy to measure with the Wright Peak Flow Minimeter. Results from this simple lightweight instrument correlate well with those from the older, bigger model.2 Predicted values vary with age, sex and height in adults;3,4 in children they are related to height alone.4,5 It is usual to record the best of three readings.

Assessment of Peak Expiratory Flow Rate in Building Construction Workers in Maharashtra

2021 ◽  
Vol 11 (6) ◽  
pp. 388-391
Author(s):  
Aditi Tanna ◽  
Sambhaji B. Gunjal
Keyword(s):  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Peak Flow ◽  
Building Construction ◽  
Construction Workers ◽  
Dust Particles ◽  
Construction Sites ◽  
Flow Meter ◽  
Expiratory Flow

Background: In this era of globalization one of the growing industries is the construction industry and there are various occupational problems faced by the workers especially in Asian countries mostly in India; the problems are related to both physical and mental health. All the construction sites generate high concentration of dust particles from cement, silica, asbestos, concrete, wood, stand and stand that causes respiratory problems in the workers. PEFR is the maximum air that is generated after forceful expiration, after full lung inspiration. So if there is any accumulation of dust particles the PEFR decreases as the elasticity of lungs to recoil is distrusted due to the lodged particles. Material and Method: A descriptive observation study was carried out on 50 building construction workers. The purpose of the study was explained and informed consent was taken. The PEFR was measured using peak expiratory flow meter. The data was analyzed using standard statistical software. Result: The procedure of using peak flow meter that was carried out for 3 times and the highest value from the three was considered as peak flow rate, using statistical method mean and standard deviation were calculated. The mean of Peak Expiratory Flow Rate is 321.1 L/min. Conclusion: This study concluded that the peak expiratory flow rate is reduced in building construction workers those who are working for than 2 years on the construction sites. Key words: construction workers, occupation diseases, PEFR, peak expiratory flow meter.

scholarly journals Home-Monitoring of Peak Expiratory Flow Rate using Mini-Wright Peak Flow Meter in Diagnosis of Asthma1

1980 ◽  
Vol 73 (10) ◽  
pp. 731-733 ◽  
Author(s):  
John G Prior ◽  
G M Cochrane
Keyword(s):  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Respiratory Symptoms ◽  
Peak Flow ◽  
Airflow Obstruction ◽  
Home Monitoring ◽  
Flow Meter ◽  
Expiratory Flow

Home-monitoring of peak expiratory flow rate using the mini-Wright peak flow meter is a useful technique for determining whether or not unexplained respiratory symptoms are caused by asthma. It is of particular value when airflow obstruction cannot be demonstrated at the time of consultation.

scholarly journals NADI SHODHANA PRANAYAMA AND ITS IMPACT ON PARAMETERS OF CARDIOVASCULAR, PULMONARY, AND BRAIN FUNCTIONS

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Shreyasi Vaksh ◽  
Dr. Mukesh Pandey
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Brain Functions ◽  
Before And After ◽  
Pressure Peak ◽  
Expiratory Flow ◽  
Underlying Mechanisms

Background: Practice of pranayama has been recognized to control cardiac autonomic status with an improvement in cardio-respiratory functions. Objective: To determine impact of Nadi-shodana pranayama practice for 20 minutes on heart rate, systolic and diastolic blood pressure, peak expiratory flow rate. Methods: Ninety normal healthy subjects aged between 17-20 years of first year MBBS course volunteered for this study out of total 150. Among them 40 were females and 50 were males. They did not have any previous training in Pranayama. All the selected physiological parameters were measured before and after performing ‘Nadi-shodhana Pranayama’. Epi-info 7 was used for analysis. Results: Following nadi-shodhana pranayama a significant decline in basal heart rate and systolic blood pressure was observed. Peak expiratory flow rate was significantly improved (P<0.01). No significant changes in respiratory and other cardiovascular parameters were seen. Conclusion: Nadi-shodhana Pranayama swiftly alters cardiopulmonary response. Further studies on a larger sample size need to illustrate the underlying mechanisms involved in this alteration. Keywords: Nadi-shodhana pranayama, heart rate, blood pressure, peak expiratory flow rate.

scholarly journals Comparison between Effect of Balloon Blowing Exercise (BBE) in Semi-Fowler (45 Degree), Upright & 90/90 Bridge with Ball Position on Peak Expiratory Flow Rate in Healthy Individuals

2021 ◽  
Vol 8 (8) ◽  
pp. 214-219
Author(s):  
Aditi Sanjay Pawaskar ◽  
Richa Bisen
Keyword(s):  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Exercise Program ◽  
Upright Position ◽  
Mechanical Equipment ◽  
Healthy Individuals ◽  
Before And After ◽  
Expiratory Flow ◽  
Group B

Purpose: This study was conducted to investigate the Comparison between effects of balloon blowing exercise (BBE) in Semi Fowlers (45 degree), Upright & 90/90 Bridge with ball position on Peak expiratory flow rate in healthy individuals. Participants & Method: Participants were randomly assigned in respective groups to perform the balloon blowing activity. The exercise programs were conducted 30 minutes per day, 5 times a week for 4 weeks, Peak expiratory flow rate was measured with mechanical equipment called Peak Expiratory Flow Meter before and after the exercise program period. Results: Effectiveness of Semi fowlers position for Balloon blowing activity is significantly more than that of Upright and 90/90 Bridge Position with Ball on Peak expiratory flow rate pre and post values(p<0.005). Conclusion: With accordance to objectives, Comparison of Peak expiratory flow rate values in pre & post exercise in three positions shows that there is improvement of group A(Semi fowlers position)> Group C(90/90 Bridge with ball position)>Group B(Upright position) Keywords: Peak expiratory flow rate (PEFR), Balloon blowing exercise (BBE), Semi fowlers position, Upright position, 90/90 Bridge will ball position.

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