Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients

2017 ◽  
Vol 131 (10) ◽  
pp. 925-929 ◽  
Author(s):  
M Erlem ◽  
N Klopp-Dutote ◽  
A Biet-Hornstein ◽  
V Strunski ◽  
C Page
Keyword(s):  
Parathyroid Hormone ◽  
Retrospective Study ◽  
Total Thyroidectomy ◽  
Serum Calcium ◽  
Univariate Analysis ◽  
Multinodular Goitre ◽  
Serum Parathyroid Hormone ◽  
Single Centre ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractObjective:To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.Methods:This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.Results:Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid glands in 3 patients). In univariate analysis, pre-operative serum 25-hydroxyvitamin D was not correlated with post-operative serum calcium (p = 0.69) or post-operative serum parathyroid hormone (p = 0.5804). Furthermore, in multivariate analysis, which took into account unintentional parathyroidectomy, no correlation was found (p = 0.33). Bilateral unintentional parathyroidectomy was statistically associated with post-operative hypocalcaemia (p = 0.032).Conclusion:Pre-operative serum 25-hydroxyvitamin D did not appear to have any impact on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre.

Serum Parathyroid Hormone and 25-Hydroxyvitamin D Concentrations Before and After Biliopancreatic Diversion

2018 ◽  
Vol 28 (7) ◽  
pp. 1886-1894 ◽  
Author(s):  
Vanessa Tardio ◽  
Jean-Philippe Blais ◽  
Anne-Sophie Julien ◽  
Pierre Douville ◽  
Stefane Lebel ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Biliopancreatic Diversion ◽  
Serum Parathyroid Hormone ◽  
Hydroxyvitamin D ◽  
Before And After ◽  
25 Hydroxyvitamin D

Serum Parathyroid Hormone in Healthy Japanese Women in Relation to Serum 25-Hydroxyvitamin D

2000 ◽  
Vol 70 (6) ◽  
pp. 287-292 ◽  
Author(s):  
Kazutoshi Nakamura ◽  
Mitsue Nashimoto ◽  
Yasushi Hori ◽  
Masaharu Yamamoto
Keyword(s):  
Parathyroid Hormone ◽  
Healthy Adult ◽  
Japanese Women ◽  
Normal Serum ◽  
Adult Women ◽  
Serum Parathyroid Hormone ◽  
Intact Pth ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship

The aim of this work was to clarify levels of serum parathyroid hormone (PTH) in healthy adult women and to study the relationship between PTH and 25-hydroxyvitamin D [25(OH)D]. One hundred sixty-nine healthy women aged 40 years or older in a community were studied. The average age of the subjects was 65.3 years (SD 8.2). All subjects had normal serum creatinine levels. Serum intact PTH and 25(OH)D were measured in these subjects. The mean intact PTH concentration was 2.19 pmol/A (SD 1.02). High intact PTH levels above the reference range were observed in four women (2.4%), all of whom were aged 70 years or older. Intact PTH increased with age with a correlation coefficient of 0.192 (p = 0.013). However, there was no correlation (r = –0.125, p = 0.105) between intact PTH and 25(OH)D whose concentrations were more than 37.5 nmol/l. In conclusion, PTH levels of healthy adult Japanese women are lower than previous reports from Western countries, which may be due to the high 25(OH)D levels of the present subjects and/or an ethnic difference. In addition, there is no association between serum 25(OH)D and PTH levels in this Japanese population, supporting a cutoff level of 25(OH)D less than 37.5 nmol/l for the elevated PTH level.

Is Normocalcemic Primary Hyperparathyroidism Harmful or Harmless?

2015 ◽  
Vol 100 (6) ◽  
pp. 2420-2424 ◽  
Author(s):  
Gang Chen ◽  
Ying Xue ◽  
Qiongyao Zhang ◽  
Ting Xue ◽  
Jin Yao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Primary Hyperparathyroidism ◽  
Serum Calcium ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Parathyroid Hormone ◽  
Hydroxyvitamin D ◽  
Outcomes Measures ◽  
25 Hydroxyvitamin D ◽  
Serum Pth

Context: Primary hyperparathyroidism (PHPT) is reported to be associated with an increased frequency of hypertension, however, information in this regard is sparse in relation to normocalcemic primary hyperparathyroidism (NPHPT). Objective: The aim of this study was to determine the association between NPHPT and blood pressure. Design, Setting, and Patients: We retrospectively enrolled 940 patients who visited the Fujian Provincial Hospital between September 2010 and December 2013 with a measured serum parathyroid hormone (PTH) and calcium level. Among them, 11 patients were diagnosed with NPHPT, while 296 cases with normal PTH and albumin-adjusted serum calcium. Main Outcomes Measures: Systolic blood pressure (SBP), diastolic blood pressure (DBP), intact serum PTH, and serum calcium were recorded. Results: There were no significant differences between subjects identified with NPHPT and those with normal PTH in terms of age, sex, body mass index, serum calcium, 25-Hydroxyvitamin D, serum creatinine, fasting plasma glucose, triglycerides, total cholesterol, high density lipoprotein, and low density lipoprotein. The subjects with a diagnosis of NPHPT had higher levels of SBP (141.9 ± 20.2 vs 131.2 ± 16.5, P = .041) and DBP (85.2 ± 12.4 vs 76.8 ± 10.3, P = .026) than the subjects in the cohort with normal PTH. After adjustment for all potential confounders, risks (odds ratios and 95% confidence interval) of SBP and DBP in NPHPT patients were 1.035 (1.000, 1.071) and 1.063 (1.004, 1.125), respectively (P < .05). Conclusions: The NPHPT had higher risk of high blood pressure than subjects with normal PTH. It is worth considering the necessity of more aggressive therapeutic intervention aimed to normalize PTH even if patients with NPHPT continue to be normocalcemic.

scholarly journals The Effect of Obesity on the Relationship Between Serum Parathyroid Hormone and 25-Hydroxyvitamin D in Women

2013 ◽  
Vol 98 (5) ◽  
pp. E886-E890 ◽  
Author(s):  
Sue A. Shapses ◽  
Esther J. Lee ◽  
Deeptha Sukumar ◽  
Ramon Durazo-Arvizu ◽  
Stephen H. Schneider
Keyword(s):  
Parathyroid Hormone ◽  
Serum Parathyroid Hormone ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship

DO NEAR-INFRARED INTRA-OPERATIVE FINDINGS OBTAINED USING INDOCYANINE GREEN CORRELATE WITH POST-THYROIDECTOMY PARATHYROID FUNCTION? THE ICGPREDICT STUDY

2020 ◽  
Vol 26 (9) ◽  
pp. 967-973
Author(s):  
Theodosios S. Papavramidis ◽  
Panagiotis Anagnostis ◽  
Angeliki Chorti ◽  
Ioannis Pliakos ◽  
Stavros Panidis ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Indocyanine Green ◽  
Total Thyroidectomy ◽  
Serum Calcium ◽  
Scoring System ◽  
Near Infrared ◽  
Eligibility Criteria ◽  
Hydroxyvitamin D ◽  
Postoperative Hypoparathyroidism ◽  
Operative Findings

Objective: Postoperative hypoparathyroidism (hypoPT) still remains a significant complication after thyroidectomy. Intra-operative imaging modalities, such as near-infrared fluorescence using indocyanine green (ICG), may assist in identifying and preserving the parathyroid glands (PGs). The purpose of this study was to test the association between the intra-operative ICG staining scoring system and 24-hour postoperative parathyroid hormone (PTH) levels, as well as its capability for intra-operative PG identification. Methods: This was a prospective study, recruiting patients scheduled for total thyroidectomy by the same surgical team, from December 2018 to April 2019. Intra-operative angiography was performed after infusion of ICG solution (5 mg). Two minutes later, images were acquired using the near-infrared system. Results: Sixty patients fulfilled the eligibility criteria. The percentage of temporary postoperative hypoPT (defined as PTH <14 pg/mL) was 11.66%. No association between intra-operative ICG staining score (expressed as the number of PGs scoring <2 per patient) and 24-hour postoperative PTH ( r = 0.011; P = .933) or serum calcium concentrations ( r = 0.127; P = .335) was observed. There was also no correlation between the location of PGs scoring ≤2 and postoperative PTH ( P = .257) or serum calcium levels ( P = .950). Moreover, with regard to secondary endpoint, ICG correctly identified PGs in 98.3% of cases. ICG score was not affected by age, gender, duration of operation, or thyroid gland pathology. No allergic reactions attributed to ICG administration were observed. Conclusion: The intra-operative ICG staining scoring system did not predict 24-hour postoperative PTH and serum calcium levels. However, this modality may assist in intra-operative PG identification during a total thyroidectomy. Abbreviations: 25(OH)D = 25-hydroxyvitamin D; hypoPT = hypoparathyroidism; ICG = indocyanine green; NIR = near-infrared; NIRF = near-infrared autofluorescence; PG = parathyroid gland; PTH = parathyroid hormone

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