A Mendelian randomization study on the role of serum parathyroid hormone and 25-hydroxyvitamin D in osteoarthritis

We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer’s disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer’s Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97–1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78–0.94; p = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD.

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The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study

Nutrition Journal ◽

10.1186/s12937-021-00735-z ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Songzan Chen ◽

Fangkun Yang ◽

Tian Xu ◽

Yao Wang ◽

Kaijie Zhang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Parathyroid Hormone ◽

Coronary Artery ◽

Mendelian Randomization ◽

Sensitivity Analyses ◽

Serum 25Ohd ◽

Hydroxyvitamin D ◽

Patients With Diabetes ◽

25 Hydroxyvitamin D ◽

Artery Disease

Abstract Background To investigate the causal association between serum 25-hydroxyvitamin D (25OHD), calcium (Ca), and parathyroid hormone (PTH) levels and the risk of coronary artery disease (CAD) in patients with diabetes using a Mendelian randomization approach. Methods Genetic signatures associated with serum 25OHD, Ca, and PTH levels were extracted from recently published genome-wide association study (GWAS), including 79,366, 39,400, 29,155 individuals, respectively. Genetic association estimates for CAD in patients with diabetes were obtained from a GWAS of 15,666 individuals with diabetes (3,968 CAD cases, 11,696 controls). The inverse-variance-weighted method was employed for the primary analysis, and other robust methods were applied for sensitivity analyses. Results Six, seven and five single nucleotide polymorphisms were identified as instrumental variables for serum 25OHD, Ca and PTH levels, respectively. There was no significant association between genetically predicted serum 25OHD levels and the risk of CAD in patients with diabetes (odds ratio (OR) = 1.04, 95% confidence interval (CI): 0.58 - 1.87, P = 0.888). Similarly, genetically predicted serum Ca (OR = 1.83, 95% CI: 0.62 – 5.35, P = 0.273) and PTH levels (OR = 1.27, 95% CI: 0.67 – 2.44, P = 0.464) were not significantly associated with the risk of CAD in patients with diabetes. These findings were robust in sensitivity analyses. Conclusions/interpretation Serum 25OHD, Ca and PTH levels may not be causally associated with the risk of CAD in patients with diabetes.

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SAT-514 The Decrease in Serum Parathyroid Hormone on Vitamin D Treatment Is Similar When Comparing Increases in Serum Free or Total 25 Hydroxyvitamin D in White and Black Women

Journal of the Endocrine Society ◽

10.1210/js.2019-sat-514 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Lynette Smith ◽

John Gallagher

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Black Women ◽

Serum Parathyroid Hormone ◽

Serum Free ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Serum Parathyroid Hormone and 25-Hydroxyvitamin D Concentrations Before and After Biliopancreatic Diversion

Obesity Surgery ◽

10.1007/s11695-017-3101-z ◽

2018 ◽

Vol 28 (7) ◽

pp. 1886-1894 ◽

Cited By ~ 7

Author(s):

Vanessa Tardio ◽

Jean-Philippe Blais ◽

Anne-Sophie Julien ◽

Pierre Douville ◽

Stefane Lebel ◽

...

Keyword(s):

Parathyroid Hormone ◽

Biliopancreatic Diversion ◽

Serum Parathyroid Hormone ◽

Hydroxyvitamin D ◽

Before And After ◽

25 Hydroxyvitamin D

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Serum Parathyroid Hormone in Healthy Japanese Women in Relation to Serum 25-Hydroxyvitamin D

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.70.6.287 ◽

2000 ◽

Vol 70 (6) ◽

pp. 287-292 ◽

Cited By ~ 10

Author(s):

Kazutoshi Nakamura ◽

Mitsue Nashimoto ◽

Yasushi Hori ◽

Masaharu Yamamoto

Keyword(s):

Parathyroid Hormone ◽

Healthy Adult ◽

Japanese Women ◽

Normal Serum ◽

Adult Women ◽

Serum Parathyroid Hormone ◽

Intact Pth ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Relationship

The aim of this work was to clarify levels of serum parathyroid hormone (PTH) in healthy adult women and to study the relationship between PTH and 25-hydroxyvitamin D [25(OH)D]. One hundred sixty-nine healthy women aged 40 years or older in a community were studied. The average age of the subjects was 65.3 years (SD 8.2). All subjects had normal serum creatinine levels. Serum intact PTH and 25(OH)D were measured in these subjects. The mean intact PTH concentration was 2.19 pmol/A (SD 1.02). High intact PTH levels above the reference range were observed in four women (2.4%), all of whom were aged 70 years or older. Intact PTH increased with age with a correlation coefficient of 0.192 (p = 0.013). However, there was no correlation (r = –0.125, p = 0.105) between intact PTH and 25(OH)D whose concentrations were more than 37.5 nmol/l. In conclusion, PTH levels of healthy adult Japanese women are lower than previous reports from Western countries, which may be due to the high 25(OH)D levels of the present subjects and/or an ethnic difference. In addition, there is no association between serum 25(OH)D and PTH levels in this Japanese population, supporting a cutoff level of 25(OH)D less than 37.5 nmol/l for the elevated PTH level.

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Basal and parathyroid hormone induced expression of the human 25-hydroxyvitamin D 1α-hydroxylase gene promoter in kidney AOK-B50 cells: role of Sp1, Ets and CCAAT box protein binding sites

The International Journal of Biochemistry & Cell Biology ◽

10.1016/s1357-2725(01)00165-0 ◽

2002 ◽

Vol 34 (8) ◽

pp. 921-930 ◽

Cited By ~ 35

Author(s):

Xiu-Hui Gao ◽

Prem P. Dwivedi ◽

Sophie Choe ◽

Frances Alba ◽

Howard A. Morris ◽

...

Keyword(s):

Parathyroid Hormone ◽

Protein Binding ◽

Binding Sites ◽

Gene Promoter ◽

Induced Expression ◽

Protein Binding Sites ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Ccaat Box

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Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients

The Journal of Laryngology & Otology ◽

10.1017/s0022215117001797 ◽

2017 ◽

Vol 131 (10) ◽

pp. 925-929 ◽

Cited By ~ 2

Author(s):

M Erlem ◽

N Klopp-Dutote ◽

A Biet-Hornstein ◽

V Strunski ◽

C Page

Keyword(s):

Parathyroid Hormone ◽

Retrospective Study ◽

Total Thyroidectomy ◽

Serum Calcium ◽

Univariate Analysis ◽

Multinodular Goitre ◽

Serum Parathyroid Hormone ◽

Single Centre ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

AbstractObjective:To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.Methods:This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.Results:Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid glands in 3 patients). In univariate analysis, pre-operative serum 25-hydroxyvitamin D was not correlated with post-operative serum calcium (p = 0.69) or post-operative serum parathyroid hormone (p = 0.5804). Furthermore, in multivariate analysis, which took into account unintentional parathyroidectomy, no correlation was found (p = 0.33). Bilateral unintentional parathyroidectomy was statistically associated with post-operative hypocalcaemia (p = 0.032).Conclusion:Pre-operative serum 25-hydroxyvitamin D did not appear to have any impact on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre.

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