Threshold value of serum 25-hydroxyvitamin D concentration in relation to elevated serum parathyroid hormone concentrations in elderly Japanese women

2006 ◽  
Vol 24 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Kazutoshi Nakamura ◽  
Mitsue Nashimoto ◽  
Yasuo Tsuchiya ◽  
Toshiko Saito ◽  
Tomoko Nishiwaki ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Elevated Serum ◽  
Threshold Value ◽  
Japanese Women ◽  
Serum Parathyroid Hormone ◽  
Hydroxyvitamin D ◽  
Elderly Japanese Women ◽  
25 Hydroxyvitamin D ◽  
Elderly Japanese

Serum Parathyroid Hormone in Healthy Japanese Women in Relation to Serum 25-Hydroxyvitamin D

2000 ◽  
Vol 70 (6) ◽  
pp. 287-292 ◽  
Author(s):  
Kazutoshi Nakamura ◽  
Mitsue Nashimoto ◽  
Yasushi Hori ◽  
Masaharu Yamamoto
Keyword(s):  
Parathyroid Hormone ◽  
Healthy Adult ◽  
Japanese Women ◽  
Normal Serum ◽  
Adult Women ◽  
Serum Parathyroid Hormone ◽  
Intact Pth ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship

The aim of this work was to clarify levels of serum parathyroid hormone (PTH) in healthy adult women and to study the relationship between PTH and 25-hydroxyvitamin D [25(OH)D]. One hundred sixty-nine healthy women aged 40 years or older in a community were studied. The average age of the subjects was 65.3 years (SD 8.2). All subjects had normal serum creatinine levels. Serum intact PTH and 25(OH)D were measured in these subjects. The mean intact PTH concentration was 2.19 pmol/A (SD 1.02). High intact PTH levels above the reference range were observed in four women (2.4%), all of whom were aged 70 years or older. Intact PTH increased with age with a correlation coefficient of 0.192 (p = 0.013). However, there was no correlation (r = –0.125, p = 0.105) between intact PTH and 25(OH)D whose concentrations were more than 37.5 nmol/l. In conclusion, PTH levels of healthy adult Japanese women are lower than previous reports from Western countries, which may be due to the high 25(OH)D levels of the present subjects and/or an ethnic difference. In addition, there is no association between serum 25(OH)D and PTH levels in this Japanese population, supporting a cutoff level of 25(OH)D less than 37.5 nmol/l for the elevated PTH level.

Are the Serum 25-Hydroxyvitamin D Concentrations in Winter Associated with Forearm Bone Mineral Density in Healthy Elderly Japanese Women?

2001 ◽  
Vol 71 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Kazutoshi Nakamura ◽  
Mitsue Nashimoto ◽  
Masaharu Yamamoto
Keyword(s):  
Cross Sectional Study ◽  
Japanese Women ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Healthy Elderly ◽  
Elderly Japanese Women ◽  
25 Hydroxyvitamin D ◽  
Elderly Japanese

The objective of this study was to investigate whether the serum 25-hydroxyvitamin D (25[OH]D) concentrations in winter are associated with the BMD in elderly Japanese women. The subjects were 117 healthy elderly Japanese women. Serum 25(OH)D concentrations were determined by high-performance liquid chromatography. Forearm BMD in the non-dominant arm was measured by dual-energy X-ray absorptiometry (DXA) using a DTX-200 Osteometer. The mean age of the subjects was 66.1 (SD 6.5) years (range: 46–80). The average 25(OH)D concentration was 59.1 nmol/L (SD 16.1), and five of the subjects had low 25(OH)D concentrations (< 30 nmol/L). Forearm BMD decreased linearly with age (r2 = 0.275). There was no linear association between the serum 25(OH)D concentrations and the forearm BMD (p = 0.9483). Multiple regression analysis did not reveal any association between the two (p = 0.5318) when age (p < 0.0001, r2 = 0.271) and weight (p < 0.0001, r2 = 0.153) were taken into account. Our cross-sectional study failed to reveal any association between the serum 25(OH)D concentrations and the forearm BMD in elderly Japanese women, suggesting that 25(OH)D does not play an important role in the determination of BMD. A follow-up study should be conducted to confirm the results of our cross-sectional study.

Serum Parathyroid Hormone and 25-Hydroxyvitamin D Concentrations Before and After Biliopancreatic Diversion

2018 ◽  
Vol 28 (7) ◽  
pp. 1886-1894 ◽  
Author(s):  
Vanessa Tardio ◽  
Jean-Philippe Blais ◽  
Anne-Sophie Julien ◽  
Pierre Douville ◽  
Stefane Lebel ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Biliopancreatic Diversion ◽  
Serum Parathyroid Hormone ◽  
Hydroxyvitamin D ◽  
Before And After ◽  
25 Hydroxyvitamin D

Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients

2017 ◽  
Vol 131 (10) ◽  
pp. 925-929 ◽  
Author(s):  
M Erlem ◽  
N Klopp-Dutote ◽  
A Biet-Hornstein ◽  
V Strunski ◽  
C Page
Keyword(s):  
Parathyroid Hormone ◽  
Retrospective Study ◽  
Total Thyroidectomy ◽  
Serum Calcium ◽  
Univariate Analysis ◽  
Multinodular Goitre ◽  
Serum Parathyroid Hormone ◽  
Single Centre ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractObjective:To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.Methods:This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.Results:Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid glands in 3 patients). In univariate analysis, pre-operative serum 25-hydroxyvitamin D was not correlated with post-operative serum calcium (p = 0.69) or post-operative serum parathyroid hormone (p = 0.5804). Furthermore, in multivariate analysis, which took into account unintentional parathyroidectomy, no correlation was found (p = 0.33). Bilateral unintentional parathyroidectomy was statistically associated with post-operative hypocalcaemia (p = 0.032).Conclusion:Pre-operative serum 25-hydroxyvitamin D did not appear to have any impact on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre.

scholarly journals The Effect of Obesity on the Relationship Between Serum Parathyroid Hormone and 25-Hydroxyvitamin D in Women

2013 ◽  
Vol 98 (5) ◽  
pp. E886-E890 ◽  
Author(s):  
Sue A. Shapses ◽  
Esther J. Lee ◽  
Deeptha Sukumar ◽  
Ramon Durazo-Arvizu ◽  
Stephen H. Schneider
Keyword(s):  
Parathyroid Hormone ◽  
Serum Parathyroid Hormone ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship

scholarly journals Analyses of Predictive Factors Associated with Hypocalcemia and Elevated iPTH with Normocalcemia after Ultrasound-guided Radiofrequency Ablation for Primary Hyperparathyroidism

2021 ◽  
Author(s):  
Hui-Hui Chai ◽  
Yu Zhao ◽  
Rui-Zhong Ye ◽  
Zeng Zeng ◽  
Zheng-Xian Zhang ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Radiofrequency Ablation ◽  
Primary Hyperparathyroidism ◽  
Predictive Factors ◽  
Elevated Serum ◽  
Intact Parathyroid Hormone ◽  
Ultrasound Guided ◽  
Serum Ipth ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Abstract Purpose To assess the feasibility of ultrasound-guided (US-guided) radiofrequency ablation (RFA) for primary hyperparathyroidism (PHPT) and determine predictive factors for hypocalcemia and elevated serum intact parathyroid hormone(ePTH) with normocalcemia after ablation. Materials and Methods Between January 2015 and January 2021, data from 44 patients with PHPT who were treated with US-guided RFA were retrospectively evaluated. Serum intact parathyroid hormone(iPTH), total calcium (Ca), phosphorus, alkaline phosphatase (ALP), and 25-hydroxyvitamin D3 (25(OH)D3) levels and the volume of the abnormal enlarged parathyroid glands were recorded before RFA. Changes in iPTH and Ca levels at 1 and 3 days, and, 1, 3, and 6 months after ablation were recorded. Results Overall, thirteen patients developed hypocalcemia 1–3 days after RFA. ePTH with normocalcemia developed in 17 patients 1 month after RFA. Thirty-two patients were followed up for more than 6 months, and 27 of these patients had sustained normalized values for both serum iPTH and Ca levels more than 6 months after RFA. There were significantly more patients who developed hypocalcaemia, when the baseline ALP was greater than 261.5 U/L (sensitivity 61.5%, specificity 100.0%). The risk of ePTH decreased by 21.7% for every 1 ng/mL increase in 25 (OH) D3. The risk of ePTH was increased when a patient's serum iPTH was higher than 172.4 pg/mL (sensitivity 88.2%, specificity 76.2%). Conclusions US-guided RFA is feasible for clinical management of PHPT patients. Hypocalcaemia following RFA was associated with higher pre-RFA serum ALP levels. Elevated iPTH levels with normocalcemia at 1 month after RFA were associated with pre-RFA vitamin D deficiency and higher baseline iPTH levels. Patients with higher serum ALP and iPTH and lower 25 (OH) D3 levels before RFA need to be managed carefully and monitored closely after RFA of PHPT.

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