Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction

2020 ◽

Vol 6 (9) ◽

pp. 1592

Author(s):

Sabeeh Beig ◽

Saifullah Khalid ◽

Satish Chandra Sharma

Keyword(s):

Otitis Media ◽

Predictive Value ◽

Plain Radiograph ◽

Chronic Otitis Media ◽

Bone Destruction ◽

Limited Information ◽

Radiological Findings ◽

Plain Radiographs ◽

Operative Findings ◽

Mastoid Surgery

Background: Computed tomography is the imaging of choice in chronic otitis media (COM) but it is neither available at every centre nor is affordable to masses of economically weaker countries. In this situation where only X-ray facility is available should plain radiographs of mastoid be done ?. If yes then what is the analytical evidence? This study, was conducted to find the utility of plain radiographs of mastoid by comparing radiological findings vis-a-vis operative findings.Methods: Pre-operative radiographs of mastoids (Schuller’s view (s/v)) were taken and the radiological findings were statistically analysed with the operative findings. Results: Plain radiograph of mastoid (s/v) predicted some of the surgical landmarks of mastoid surgery viz tegmen and sinus plates with a fair degree of accuracy. The positive predictive value (PPV) for radiolucent shadow (assumed to indicate bone destruction and thus cholesteatoma) was also high but at the same time, a low negative predictive value and a Cohen’s kappa test showing only a fair agreement underscores the point that absence of a radiolucent shadow does not rule out the presence of cholesteatoma.Conclusions: Radiographs of mastoid are helpful in providing a prior knowledge of the surgical landmarks in mastoid surgery. Hence with this information, if a surgeon finds himself more at ease in operating a patient then this imaging should be done when CT scan facility is unavailable. However, citing the limited information on other aspects of the disease, its use as a ‘routine’ investigation in chronic otitis media is discouraged.

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Bone Destruction Mechanisms in Chronic Otitis Media with Cholesteatoma: Specific Production by Cholesteatoma Tissue in Culture of Bone-Resorbing Activity Attributable to Interleukin-1 Alpha

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949110001207 ◽

1991 ◽

Vol 100 (12) ◽

pp. 989-998 ◽

Cited By ~ 23

Author(s):

Atsushi Kurihara ◽

Ryo Yuasa ◽

Masaru Toshima ◽

Tomonori Takasaka

Keyword(s):

Otitis Media ◽

Calcium Release ◽

Interleukin 1 ◽

Chronic Otitis Media ◽

Bone Destruction ◽

Enzyme Linked Immunosorbent Assay ◽

Pg E2 ◽

Culture Supernatants ◽

Bone Resorbing Activity

To clarify specific mechanisms underlying cholesteatoma-induced bone destruction, surgical specimens of middle ear inflammatory granulation tissue with or without cholesteatoma were maintained in vitro and the bone-resorbing activity in their culture supernatants was analyzed by means of calcium release from mouse calvaria. Almost the same levels of bone-resorbing activity and prostaglandin (PG) E2 were found in the supernatants of both types of tissue. By contrast, aural polyp tissue yielded hardly any such activity or PGE2. Under the influence of indomethacin, however, only tissue with cholesteatoma produced considerable bone resorption activity, whereas PGE2 production was suppressed completely. Such activity in the cholesteatoma culture supernatant was not due to contamination of endotoxin and proved to be blocked by the introduction of anti-interleukin (IL)-1α antibody into the calvarial assay system. Anti-IL-1β antibody had no effect on such activity. Interleukm-1α was detected only in cholesteatoma tissue culture supernatants by means of enzyme-linked immunosorbent assay and by bioassay. These data suggest that the bone destruction in otitis media with cholesteatoma may be attributed to IL-1α in addition to PGE2.

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Temporal bone meningioma

Otorinolaryngologie a foniatrie ◽

10.48095/ccorl202122 ◽

2021 ◽

Vol 70 (1) ◽

pp. 22-26

Author(s):

Barbora Blatová ◽

Karol Zeleník ◽

Martin Formánek ◽

Štefan Reguli ◽

Pavla Hanzlíková ◽

...

Keyword(s):

Computed Tomography ◽

Case Report ◽

Magnetic Resonance ◽

Temporal Bone ◽

Otitis Media ◽

Chronic Otitis Media ◽

Bone Destruction ◽

Rare Condition ◽

Stereotactic Irradiation

The aim of this case report is to discuss a very rare pathology – temporal bone meningioma. The extracranial location of meningiomas and temporal bone meningioma is a very rare condition. The symptomatology of temporal bone meningiomas is nonspecific, imitating chronic otitis media with cholesteatoma. However, temporal bone meningioma has a distinctive image on computed tomography. There is a change in the architecture without bone destruction that should be known by otorhinolaryngologist and radiologist. Magnetic resonance paging should be performed when temporal bone meningioma is suspected. The management of temporal bone meningiomas depends on a variety of factors. The most common therapy includes a combination of neurosurgical and otological surgery. There are also alternatives like stereotactic irradiation.

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Bone Damage in Chronic Otitis Media

Ear Nose & Throat Journal ◽

10.1177/0145561320955124 ◽

2020 ◽

pp. 014556132095512

Author(s):

Jerzy Kuczkowski ◽

Wojciech Brzoznowski ◽

Tomasz Nowicki

Keyword(s):

Otitis Media ◽

Middle Ear ◽

Chronic Otitis Media ◽

Bone Destruction ◽

Destructive Effect ◽

Highly Active ◽

Bone Damage ◽

Bone Lysis ◽

Factor Α ◽

Necrosis Factor

The middle ear bone destruction in chronic otitis media is activated and regulated by inflammation. Chronic otitis media with granulation is a highly active inflammatory process in which many cytokines are released. The bone is degraded by osteoclasts but, at the same time, protected by cytokines, growth factors, adhesion molecules and osteotropic hormones. Tumor necrosis factor-α, interleukin (IL)-1, IL-6, and OPG/RANKL present in cholesteatoma and granulation accelerate bone lysis and increase the destructive effect on the middle ear.

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Bone Resorption in Chronic Otitis Media

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348947908800517 ◽

1979 ◽

Vol 88 (5) ◽

pp. 693-700 ◽

Cited By ~ 17

Author(s):

Bruce J. Gantz ◽

Jerry Maynard ◽

Robert M. Bumsted ◽

Cheng Chun Huang ◽

Maxwell Abramson

Keyword(s):

Acid Phosphatase ◽

Bone Resorption ◽

Otitis Media ◽

Bone Cells ◽

Chronic Otitis Media ◽

Bone Destruction ◽

Inflammatory Cells ◽

Cellular Origin ◽

Osteocyte Lacunae ◽

Temporal Bones

Bone resorption is an important aspect of chronic otitis media contributing to many complications of this disease. It is postulated that the mechanism of this localized destructive process is chemical in origin. Collagenase, lysosomal enzymes, prostaglandins, and other cell mediators are thought to induce bone resorption, but the site of action and cellular origin of these substances remains unclear. In this report, we demonstrate the location and attempt to delineate the cellular origin of two enzymes, collagenase and the lysosomal enzyme acid phosphatase in guinea pig temporal bones and human ossicles from ears containing chronic otitis media. Tissue localization of these enzymes identifies sites of active bone resorption and demonstrates the cells initiating this process. Using immunohistochemical and immunocytochemical techniques, collagenase was seen surrounding mononuclear inflammatory cells of granulation tissue at bone resorbing margins and at the periphery of osteocyte lacunae adjacent to resorbing areas. Electron microscopic data suggests that collagenase is an extracellular enzyme found at the periphery of osteocytes. In addition, abundant acid phosphatase activity was seen in the same cells that exhibited collagenase staining, lending credence to the destructive function of these cells. The chronic inflammatory reaction found in chronic otitis media appears to activate bone destruction through the dynamic activity of mononuclear inflammatory cells and stimulates bone cells to increase their destructive biochemical functions.

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