scholarly journals Bone Damage in Chronic Otitis Media

2020 ◽  
pp. 014556132095512
Author(s):  
Jerzy Kuczkowski ◽  
Wojciech Brzoznowski ◽  
Tomasz Nowicki
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Bone Destruction ◽  
Destructive Effect ◽  
Highly Active ◽  
Bone Damage ◽  
Bone Lysis ◽  
Factor Α ◽  
Necrosis Factor

The middle ear bone destruction in chronic otitis media is activated and regulated by inflammation. Chronic otitis media with granulation is a highly active inflammatory process in which many cytokines are released. The bone is degraded by osteoclasts but, at the same time, protected by cytokines, growth factors, adhesion molecules and osteotropic hormones. Tumor necrosis factor-α, interleukin (IL)-1, IL-6, and OPG/RANKL present in cholesteatoma and granulation accelerate bone lysis and increase the destructive effect on the middle ear.

Determining Otitis Media Severity from Middle Ear Fluid Analysis

1994 ◽  
Vol 103 (5_suppl) ◽  
pp. 43-45 ◽  
Author(s):  
Steven K. Juhn ◽  
William J. Garvis ◽  
Chap T. Le ◽  
Chris J. Lees ◽  
C. S. Kim
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Complex Nature ◽  
Fluid Analysis ◽  
Factor Α ◽  
Necrosis Factor ◽  
Ear Effusion ◽  
Chemical Mediators

Otitis media has a complex multifactorial pathogenesis, and the middle ear inflammatory response is typified by the accumulation of cellular and chemical mediators in middle ear effusion. However, specific biochemical and immunochemical factors that may be responsible for the severity or chronicity of otitis media have not been identified. Identification of factors involved in chronicity appears to be an essential step in the treatment and ultimate prevention of chronic otitis media. We analyzed 70 effusion samples from patients 1 to 10 years of age who had chronic otitis media with effusion for two cytokines (interleukrn-1β and tumor necrosis factor α) and total collagenase. The highest concentrations of all three inflammatory mediators were found in purulent otitis media, and concentrations were higher in younger than in older patients. Mediator concentrations were similar in samples obtained from patients having their first myringotomy for otitis media with effusion and in those who had had multiple previous myringotomies. The multiresponse star, which incorporates several biochemical parameters in one graphic illustration, may best characterize the complex nature of middle ear inflammation.

scholarly journals Induction of Mucin Gene Expression in Middle Ear of Rats by Tumor Necrosis Factor–α: Potential Cause for Mucoid Otitis Media

2000 ◽  
Vol 182 (3) ◽  
pp. 882-887 ◽  
Author(s):  
Jizhen Lin ◽  
Atsushi Haruta ◽  
Hirokazu Kawano ◽  
Samuel B. Ho ◽  
George L. Adams ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Necrosis Factor ◽  
Otitis Media ◽  
Middle Ear ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Mucin Gene ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Patterns of Bone Damage in Patients With Chronic Middle Ear Inflammation

2020 ◽  
pp. 014556132092414
Author(s):  
Agnieszka Wiatr ◽  
Pawel Strek ◽  
Maciej Wiatr
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Inflammatory Process ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Bone Lesions ◽  
Scanning Microscope ◽  
Inflammatory Lesions ◽  
Bone Damage ◽  
Intracranial Complications

Background: Despite different etiologies, chronic otitis media involves the damaging and restructuring of bone tissue. The inflammatory process destroys elements of the ossicular chain, and bone lesions may appear that allow the development of otogenous complications. Aims/Objectives: A correlation between the degree of damage to the ossicular chain as well as the bony walls of the middle ear and the type of chronic inflammatory lesions was sought. Destructive changes to bones were observed using scanning microscopy. Material and Methods: The removed damaged fragments of the ossicles were prepared for evaluation with a scanning microscope. Preparations were sputter-coated with a thin layer of gold and subsequently evaluated. Results: Of 220 surgeries carried out in the discussed period, destruction of the middle ear bone walls, opening the way for the development of intracranial complications, was found in 27 patients. Most of them had ongoing chronic otitis media with granulation. Conclusions: (1) Bone loss of the skull base was observed more frequently in patients with chronic otitis media with granulation than with cholesteatoma. (2) In chronic otitis media with cholesteatoma, damage to the ossicular chain was observed significantly more frequently than in the case of otitis media with granulation.

Expression of Tumor Necrosis Factor-α, Interleukin-1α, Interleukin-6 and Interleukin-10 in Chronic Otitis Media with Bone Osteolysis

ORL ◽  
2011 ◽  
Vol 73 (2) ◽  
pp. 93-99 ◽  
Author(s):  
Jerzy Kuczkowski ◽  
Monika Sakowicz-Burkiewicz ◽  
Ewa Iżycka-Świeszewska ◽  
Bogusław Mikaszewski ◽  
Tadeusz Pawełczyk
Keyword(s):  
Tumor Necrosis Factor ◽  
Otitis Media ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Chronic Otitis Media ◽  
Interleukin 10 ◽  
Interleukin 1Α ◽  
Factor Α ◽  
Necrosis Factor

Relationship of Endotoxin to Tumor Necrosis Factor–α and Interleukin-1β in Children with Otitis Media with Effusion

1998 ◽  
Vol 107 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Darryl N. Willett ◽  
Rod P. Rezaee ◽  
John M. Billy ◽  
Mary B. Tighe ◽  
Thomas F. DeMaria
Keyword(s):  
Otitis Media ◽  
Total Protein ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Tnf Α ◽  
Factor Α ◽  
Mean Concentration ◽  
Necrosis Factor

Sixty-five middle ear effusions and paired sera from 41 children with chronic otitis media with effusion were assayed for endotoxin and for tumor necrosis factor–α (TNF-α) and interleukin-1β (IL-1β) in order to establish whether a correlation exists between the concentrations of endotoxin and of these cytokines. Endotoxin concentration was determined by means of a chromogenic limulus amebocyte lysate assay, and the cytokine concentration by means of a quantitative enzyme-linked immunosorbent assay. Forty percent of the effusions had detectable levels of endotoxin, with a mean concentration of 2.9 ± 7.8 endotoxin units per milligram of total protein. The mean concentration of TNF-α was 1.24 ± 3.1 pg/mg total protein, and that of IL-1β was 18.79 pg/mg total protein. A strong, statistically significant correlation exists between the concentrations of endotoxin and TNF-α (r =.89) and IL-1β (r =.72). The data indicate that endotoxin may contribute to the pathogenesis of chronic otitis media with effusion by stimulating the sustained production of TNF-α and IL-1β in the middle ear.

Comparison of the Aditus ad Antrum Diameter on CT between Patients with Chronic Otitis Media and Healthy Individuals

2019 ◽  
Vol 15 (10) ◽  
pp. 990-993 ◽  
Author(s):  
Elif Gündoğdu ◽  
Uğur Toprak
Keyword(s):  
Computed Tomography ◽  
Otitis Media ◽  
Middle Ear ◽  
Healthy Subjects ◽  
Normal Values ◽  
Chronic Otitis Media ◽  
Healthy Individuals ◽  
Inner Diameter ◽  
Male Patients ◽  
The Right

Background: The middle ear cavity is ventilated through the aditus ad antrum. Aditus blockage contributes to the pathology of otitis media. Objective: To determine the normal values of the aditus ad antrum diameter on computed tomography and to investigate its relationship with chronic otitis media and related pathologies (tympanosclerosis and myringosclerosis). Methods: The temporal CT images of 162 individuals were evaluated retrospectively. In the axial sections, the inner diameter of the aditus was measured at the narrowest point at the cortex. The differences in diameter were compared between diseased and healthy ears. Results: In healthy individuals, the diameter was narrower in women. There was no difference between the right and left ears in healthy subjects. No correlation was found between age and diameter. In male patients with myringosclerosis, the diameter was slightly narrower on both sides but more marked on the left. In female patients with myringosclerosis, the diameter in both ears was slightly narrower. In cases of otitis media and tympanosclerosis, the diameter was less than that of healthy individuals, despite the lack of statistically significant result in all cases. Conclusion: The aditus ad antrum was narrower in diseased ears, indicating that a blocked aditus may contribute to the development of otitis media, as well as mucosal diseases.

scholarly journals Tissue Concentrations of Enoxacin in the Middle Ear of Patients with Chronic Otitis Media.

1992 ◽  
Vol 85 (1) ◽  
pp. 131-135
Author(s):  
Nozomu Mori ◽  
Akio Shugyo ◽  
Hiroshi Furuta ◽  
Yasuki Watanabe ◽  
Takafumi Kawahara ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Tissue Concentrations

Medical tactics in chronic otitis media

1995 ◽  
Vol 76 (1) ◽  
pp. 23-25
Author(s):  
R. M. Nursaitova ◽  
O. A. Guryanov
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Potential Danger

It is advisable to perform cautious radical operations at the same time with plasty elements. The early surgicai sanation of the middle ear is recommended allowing to preserve its elements, to increase the possibilities of reconstruction and consequently, to decrease a potential danger for acoustic function of a patient as well as for his life as a whole.

scholarly journals Clinical analysis on surgery of middle ear cholesteatoma and chronic otitis media

2016 ◽  
Vol 130 (S3) ◽  
pp. S221-S221
Author(s):  
Ayiheng Qukuerhan ◽  
Nilipaer Alimu ◽  
Halimulati Muertiza ◽  
Pilidong Kuyaxi
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Clinical Analysis ◽  
Middle Ear Cholesteatoma

Tumor necrosis factor-α and interleukin-1 β levels in recurrent and persistent otitis media with effusion

2002 ◽  
Vol 126 (4) ◽  
pp. 417-422 ◽  
Author(s):  
Sertac Yetiser ◽  
Bulent Satar ◽  
Atilla Gumusgun ◽  
Faruk Unal ◽  
Yalcin Ozkaptan
Keyword(s):  
Tumor Necrosis Factor ◽  
Otitis Media ◽  
Tumor Necrosis ◽  
Otitis Media With Effusion ◽  
Interleukin 1 ◽  
Tertiary Referral Center ◽  
Adenoid Tissue ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

OBJECTIVE: Based on interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels in effusions, our goals were to specify either recurrent or persistent otitis media with effusion (OME) is a mid stage in the development of chronic disease and to identify the factors that have an influence on cytokine levels. STUDY DESIGN: Samples from groups with recurrent (n = 15) and persistent (n = 39) OME were essayed for IL-1 β and TNF-α. Children were also grouped with respect to age, sex, quality of effusion, and the presence of pharyngeal adenoid tissue. SETTING: Tertiary referral center. RESULTS: In recurrent and persistent OME groups, IL-1β was higher than TNF-α ( P < 0.01). IL-β was higher in recurrent OME than in persistent OME ( P < 0.05). CONCLUSION: Recurrent OME seems to be closer to the chronic stage of the disease relative to persistent OME in terms of higher IL-1 β levels. Each exacerbation of acute disease in recurrent otitis media is likely to be mediated by IL-1 β. SIGNIFICANCE: We were able to clarify that recurrent OME is a stage that occurs before chronic OME. Therefore, the prevention of acute attacks in recurrent disease would also impede long-term damage to the middle ear.

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