Biochemical and behavioural effects of acute tryptophan depletion in abstinent bulimic subjects: a pilot study

1995 ◽  
Vol 25 (5) ◽  
pp. 995-1001 ◽  
Author(s):  
A. Oldman ◽  
A. Walsh ◽  
P. Salkovskis ◽  
C. G. Fairburn ◽  
P. J. Cowen
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Free Amino ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Healthy Controls ◽  
Behavioural Effects ◽  
Amino Acid Load ◽  
Healthy Female ◽  
Acid Load

SYNOPSISWe studied the effect of acute tryptophan (TRP) depletion in a group of eight abstinent bulimic (BN) subjects and in 12 healthy female controls. Despite being free of episodes of bingeeating and vomiting for a prolonged period, the abstinent BN subjects still appeared to practice dietary restraint as judged by their food intake in a test meal. In addition, their plasma TRP concentrations were significantly lower than those of the controls. Administration of a TRP-free amino acid load (52 g) significantly lowered plasma total and free TRP. However, compared to a balanced amino acid load, this procedure did not have significant effects on mood, appetite or food intake in either the abstinent BN subjects or the healthy controls.

scholarly journals Taste aversion induced by an histidine-free amino acid load

1974 ◽  
Vol 2 (3) ◽  
pp. 349-351 ◽  
Author(s):  
D. A. Booth ◽  
P. C. Simson
Keyword(s):  
Amino Acid ◽  
Free Amino Acid ◽  
Taste Aversion ◽  
Free Amino ◽  
Amino Acid Load ◽  
Acid Load

The disposal of an intravenously administered amino acid load across the human forearm

Metabolism ◽  
1982 ◽  
Vol 31 (5) ◽  
pp. 463-470 ◽  
Author(s):  
Naji N. Abumrad ◽  
David Rabin ◽  
Kendall L. Wise ◽  
W.W. Lacy
Keyword(s):  
Amino Acid ◽  
Amino Acid Load ◽  
Human Forearm ◽  
Acid Load

scholarly journals EFFECT OF HYDROCHLORIDE-FREE AMINO ACID MIXTURE ON GROWTH AND FOOD INTAKE IN RATS

1974 ◽  
Vol 20 (6) ◽  
pp. 431-436
Author(s):  
Hiroshi ITOH ◽  
Tetsuya KISHI ◽  
Masahiro EMA ◽  
Ichiro CHIBATA
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Free Amino Acid ◽  
Free Amino ◽  
Amino Acid Mixture ◽  
Acid Mixture

THE CONTROL OF ARGININE-INDUCED INSULIN SECRETION IN THE RAT: THE ROLE OF CATECHOLAMINES

1973 ◽  
Vol 58 (1) ◽  
pp. 111-122 ◽  
Author(s):  
R. A. BACCHUS ◽  
L. MEADE ◽  
J. S. M. HUTCHINSON ◽  
D. R. LONDON
Keyword(s):  
Insulin Secretion ◽  
Blood Glucose ◽  
Amino Acid ◽  
Insulin Response ◽  
Catecholamine Metabolism ◽  
Catecholamine Synthesis ◽  
Amino Acid Load ◽  
Acid Load ◽  
Anaesthetized Rat

SUMMARY The effect of alterations in catecholamine metabolism on arginine-induced insulin release was studied in the anaesthetized rat. Alpha-methyl-p-tyrosine, which inhibits catecholamine synthesis, guanethidine, which prevents catecholamine release, and reserpine, which depletes catecholamine stores, all enhanced the secretion of insulin and reduced the rise in blood glucose after the amino acid load. Adrenalectomy, with or without corticosterone replacement, had a similar effect. Adrenaline inhibited the insulin response to arginine. It was concluded that in the rat, adrenergic mechanisms modulate the insulin response to arginine.

scholarly journals Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity

2010 ◽  
Vol 3 ◽  
pp. IJTR.S4317 ◽  
Author(s):  
Donald M. Dougherty ◽  
Dawn M. Richard ◽  
Lisa M. James ◽  
Charles W. Mathias
Keyword(s):  
Amino Acid ◽  
Response Inhibition ◽  
Acute Tryptophan Depletion ◽  
Future Research ◽  
Placebo Control ◽  
Tryptophan Depletion ◽  
Biological Processes ◽  
Response Initiation ◽  
Different Types ◽  
Behavioral Impulsivity

Introduction While central nervous system serotonin has been implicated in a variety of problematic impulsive behaviors, biological manipulation of brain serotonin using acute tryptophan depletion for studying changes in impulsive behavior has received little attention. Methods Using identical treatment conditions, we examined the effects of reduced serotonin synthesis for each of three matched groups using acute tryptophan depletion. Thirty healthy men and women (ages 18–45) were assigned to perform one of three tasks assessing different types of behavioral impulsivity: response initiation, response inhibition, and consequence sensitivity ( N = 90). Participants completed two experimental days during which each consumed either a tryptophan-depletion or balanced-placebo amino-acid formulation and completed 5 sessions of their respective tasks at 0.25 h before and 1.5, 4.0, 5.0, and 6.0 h after beverage consumption. Results During peak effectiveness (5.0 h to 6.0 h following amino-acid consumption), depletion produced selective differences dependent on the type of impulsivity being tested. Specifically, relative to baseline testing (pre-depletion), response initiation impulsivity was significantly increased during the peak effects of depletion. And, when compared to placebo control, both response initiation and consequence sensitivity impulsivity were increased during the peak effects of depletion. Conclusion Though response initiation and consequence sensitivity impulsivity were affected by tryptophan depletion, response inhibition impulsivity was not, suggesting that other biological processes may underlie this specific component of impulsivity. Future research in other populations or using different pharmacological agents is warranted to further examine the biological processes underlying these components of impulsivity.

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