XVIII.—Histochemical Studies of Keratin Fibres

1946 ◽  
Vol 62 (2) ◽  
pp. 132-136 ◽  
Author(s):  
J. L. Stoves
Keyword(s):  
Preliminary Report ◽  
Chemical Reactivity ◽  
Detailed Account ◽  
Micro Structure ◽  
Suitable Material ◽  
Animal Hair ◽  
Keratin Fibres

During a study of the micro-structure of keratin fibres (Stoves, 1944) it was found that certain members of the Mustelidæ, e.g. kolinsky (M. Sibirica), ermine (M. erminœ), and Jap mink (M. itatsi), possess primary hairs with well-developed cuticle, cortex, and medulla. In the case of rabbits and hares (Leporidæ), however, the corresponding fibres are composed almost entirely of medulla cells. The two types of fibres, therefore, provide suitable material for studying the chemical reactivity of the keratin constituting cuticle, cortex, and medulla of animal hair. Accordingly, the effect of various reagents upon transverse sections of fibres from the above-mentioned animals was examined, and a preliminary report of the results has already been made (Stoves, 1943 a). A more detailed account of the work now appears.

MC4703 A New Phenothiazine Derivative

1958 ◽  
Vol 104 (436) ◽  
pp. 870-872 ◽  
Author(s):  
J. G. Hegarty
Keyword(s):  
Clinical Evaluation ◽  
Preliminary Report ◽  
Detailed Account ◽  
Trifluoromethyl Group ◽  
Phenothiazine Derivative

MC4703 is a new phenothiazine derivative which contains a trifluoromethyl group and which was made available in the form of 10 mg. and 50 mg. tablets by E. R. Squibb & Sons for clinical evaluation as an ataractic or “tranquillizing” agent. The interesting results obtained with the drug justify the presentation of this brief, preliminary report, but a more detailed account of the investigation will be supplied in due course.

scholarly journals The swelling of structured proteins - The influence of the reticular tissue on the swelling of collagen in water and hydrochloric acid

1935 ◽  
Vol 118 (810) ◽  
pp. 439-445 ◽  
Keyword(s):  
Collagen Fibre ◽  
Hair Shaft ◽  
Collagen Fibres ◽  
Suitable Material ◽  
Cellular Origin ◽  
Cohesive Forces ◽  
Fibrous Protein ◽  
External Stresses ◽  
Reticular Tissue ◽  
Keratin Fibres

Previous observations on the swelling of fibrous tissues and fibres (Kaye and Jordan-Lloyd, 1924, a ; Marriott, 1932; Jordan-Lloyd, Marriott, and Pleass, 1933; Jordan-Lloyd and Marriott, 1933, 1934) have shown that the swelling of biological material is largely influenced by its structure. Even a fibre that is histologically structureless, as, for example, a fibre of silk-fibroin (silk-gut), can be shown to consist of a number of fine fibrils held together by lateral cohesive forces. Both with silk fibres and keratin fibres (horsehair), the evidence suggests that the structure of the fibre is maintained by what may be described as an equivalent of a system of internal girders, these girders being the lateral cohesive forces between the molecules. Keratin fibres (hairs) are of cellular origin, though a fibrous rather than a cellular structure exists in the hair shaft. Collagen fibres are also of cellular origin, though in their fully developed form they are by no means such rigid structures as silk fibres or hairs, and swell much more freely. It has been shown already that the swelling of collagen fibres, while woven together to form the tissue of the skin, depends both on the structure of the fibres and on the pattern of the weave, skin pieces where the weave is loose swelling more freely under the same conditions than skin pieces where the weave is more compact (Kaye and Jordan-Lloyd, 1924). Moreover, it has also been shown that if the fibres were invested with a film of coagulated protein, swelling was less than under fresh conditions. Swelling is, therefore, also a function of the external stresses exerted on the fibre, a generalization confirmed by Marriott (1932) in a study of the behaviour of single collagen fibre bundles teased out of the skin tissue. Collagen fibres cannot be obtained free from all other tissues. They are invested and held together throughout the skin by another fibrous protein, the reticular tissue (Kaye, 1929; Kuntzel and Prakke, 1933). This tissue forms the equivalent of a system of external girders round the actual collagen fibres and influences their behaviour. Collagen fibres from skin which were used in the earlier work are not a suitable material for the study of the influence of the reticular tissue on the swelling of collagen owing to the difficulty of teasing out a good supply of undamaged, suitable single fibres in a reasonably short space of time from fresh skin. For this reason the tendons from rats’ tails were selected for study. Previous work on the swelling of tendons has been recorded by Kuntzel (1926) and of their structure by Kuntzel and Prakke (1933).

THE MIDDLE HELLADIC POTTERY OF LEFKANDI PHASES IV–VI: AN INTRODUCTION

2020 ◽  
Vol 115 ◽  
pp. 133-174
Author(s):  
Oliver Dickinson
Keyword(s):  
Preliminary Report ◽  
Detailed Account ◽  
Middle Helladic ◽  
Relevant Material ◽  
Phase Iv ◽  
Three Phases

This paper presents a more detailed account of the pottery of Phases IV–VI in the Middle Helladic (MH) sequence at Lefkandi: Xeropolis than is available in the preliminary report. It is based essentially on an unfinished draft compiled by Roger Howell (the Howell manuscript). After an introduction on the background, there is discussion of the Howell manuscript, and then an analysis of the stratigraphy of Trench CC, the basis for the phasing of the pre-Mycenaean phases of Lefkandi; brief comments are also provided on those trial trenches that produced relevant material. The pottery of the three phases is then set out in detail, with attention to the relative popularity of wares and the shapes within those wares, and to possible imports, and they are argued to be classifiable as later ‘MH I’ (Phase IV), advanced ‘MH II’ (Phase V), and the early Mycenaean period, quite possibly starting in ‘MH III’ but continuing well into Late Helladic II (Phase VI). A summary sets out some distinctive characteristics of the Lefkandi sequence, as deducible from this material, and some general conclusions.

Progress report on 21-cm observations at low latitude between longitudes (l 11) 0° and 66°

1967 ◽  
Vol 31 ◽  
pp. 177-179
Author(s):  
W. W. Shane
Keyword(s):  
Preliminary Report ◽  
Progress Report ◽  
Galactic Centre ◽  
Low Latitude ◽  
The Third ◽  
Introductory Lecture ◽  
Centre Region

In the course of several 21-cm observing programmes being carried out by the Leiden Observatory with the 25-meter telescope at Dwingeloo, a fairly complete, though inhomogeneous, survey of the regionl11= 0° to 66° at low galactic latitudes is becoming available. The essential data on this survey are presented in Table 1. Oort (1967) has given a preliminary report on the first and third investigations. The third is discussed briefly by Kerr in his introductory lecture on the galactic centre region (Paper 42). Burton (1966) has published provisional results of the fifth investigation, and I have discussed the sixth in Paper 19. All of the observations listed in the table have been completed, but we plan to extend investigation 3 to a much finer grid of positions.

Shared Intentionality, joint commitment, and directed obligation

2020 ◽  
Vol 43 ◽  
Author(s):  
Margaret Gilbert
Keyword(s):  
Detailed Account ◽  
Joint Commitment ◽  
Shared Intentionality

Abstract Tomasello frequently refers to joint commitment, but does not fully characterize it. In earlier publications, I have offered a detailed account of joint commitment, tying it to a sense that the parties form a “we,” and arguing that it grounds directed obligations and rights. Here I outline my understanding of joint commitment and its normative impact.

Preliminary Report of a Comparative Study of Seminiferous Tubular Epithelium from Rats Flown on Cosmos 1887 and SL3

1988 ◽  
Vol 46 ◽  
pp. 276-277
Author(s):  
Walter J. Sapp ◽  
D.E. Philpott ◽  
C.S. Williams ◽  
K. Kato ◽  
J. Stevenson ◽  
...  
Keyword(s):  
Space Flight ◽  
Physiological Response ◽  
Preliminary Report ◽  
Complete Recovery ◽  
Environmental Constraints ◽  
Tubular Epithelium ◽  
Testicular Weight ◽  
Testicular Morphology ◽  
Normal Offspring ◽  
Rats And Mice

Space flight, with its unique environmental constraints such as immobilization, decreased and increased pressures, and radiation, is known to affect testicular morphology and spermatogenesis. Selye, summarized the manifestations of physiological response to nonspecific stress and he pointed out that atrophy of the gonads always occurred. Reports of data collected from two dogs flown in space for 22 days (Cosmos 110) indicate that there was an increase of 30 to 70% atypical spermatozoa when compared to ground based controls. Seventy-five days after the flight the abnormalities had decreased to the high normal value of 30% and mating of these dogs after this period produced normal offspring, suggesting complete recovery. Effects of immobilization and increased gravity were investigated by spinning rats and mice at 2x g for 8-9 weeks. A decrease in testicular weight was noted in spun animals when compared to controls. Immobilization has been show to cause arrest of spermatogenesis in Macaca meminstrins.

Small Angle Electron Scattering From Vacuum Condensed Metallic Films

1968 ◽  
Vol 26 ◽  
pp. 380-381
Author(s):  
J. Silcox ◽  
R. H. Wade
Keyword(s):  
Electron Scattering ◽  
Small Angle ◽  
Ring Structure ◽  
Two Dimensional ◽  
Metallic Films ◽  
Micro Structure ◽  
Angle Scattering ◽  
The Fourier Transform ◽  
Source Of Information ◽  
Kinematical Theory

Recent work has drawn attention to the possibilities that small angle electron scattering offers as a source of information about the micro-structure of vacuum condensed films. In particular, this serves as a good detector of discontinuities within the films. A review of a kinematical theory describing the small angle scattering from a thin film composed of discrete particles packed close together will be presented. Such a model could be represented by a set of cylinders packed side by side in a two dimensional fluid-like array, the axis of the cylinders being normal to the film and the length of the cylinders becoming the thickness of the film. The Fourier transform of such an array can be regarded as a ring structure around the central beam in the plane of the film with the usual thickness transform in a direction normal to the film. The intensity profile across the ring structure is related to the radial distribution function of the spacing between cylinders.

Electron Probe Analysis of Vertebrate Smooth Muscle: Distribution of Ca and Ci

1976 ◽  
Vol 34 ◽  
pp. 334-335 ◽  
Author(s):  
Avril V. Somlyo ◽  
H. Shuman ◽  
A.P. Somlyo
Keyword(s):  
Smooth Muscle ◽  
Electron Probe ◽  
Preliminary Report ◽  
Cell Damage ◽  
Electron Probe Analysis ◽  
Perinuclear Space ◽  
Probe Analysis ◽  
High K ◽  
Low K ◽  
Initial Results

This is a preliminary report of electron probe analysis of rabbit portal-anterior mesenteric vein (PAMV) smooth muscle cryosectioned without fixation or cryoprotection. The instrumentation and method of electron probe quantitation used (1) and our initial results with cardiac (2) and skeletal (3) muscle have been presented elsewhere.In preparations depolarized with high K (K2SO4) solution, significant calcium peaks were detected over the sarcoplasmic reticulum (Fig 1 and 2) and the continuous perinuclear space. In some of the fibers there were also significant (up to 200 mM/kg dry wt) calcium peaks over the mitochondria. However, in smooth muscle that was not depolarized, high mitochondrial Ca was found in fibers that also contained elevated Na and low K (Fig 3). Therefore, the possibility that these Ca-loaded mitochondria are indicative of cell damage remains to be ruled out.

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