The limbic basal-ganglia-thalamocortical circuit and goal-directed behavior

1999 ◽  
Vol 22 (3) ◽  
pp. 525-526 ◽  
Author(s):  
Daphna Joel
Keyword(s):  
Basal Ganglia ◽  
Motivational State ◽  
Prefrontal Cortical ◽  
Interconnected Model ◽  
Goal Directed Behavior

Depue & Collins's model of incentive-motivational modulation of goal-directed behavior subserved by a medial orbital prefrontal cortical (MOC) network is appealing, but it leaves several questions unanswered: How are the stimuli that elicit an incentive motivational state selected? How does the incentive motivational state created by the MOC network modulate behavior? What is the function of the dopaminergic input to the striatum? This commentary suggests possible answers, based on the open-interconnected model of basal-ganglia-thalamocortical circuits, in which the limbic circuit selects goals and, via its connections with the motor and the associative circuits, directs behavior according to those goals, elaborating on the role of dopamine.

scholarly journals Striatonigrostriatal Spirals in Addiction

2021 ◽  
Vol 15 ◽  
Author(s):  
Andy Sivils ◽  
John Q. Wang ◽  
Xiang-Ping Chu
Keyword(s):  
Substance Use ◽  
Basal Ganglia ◽  
Positive Emotions ◽  
Physiological Role ◽  
Reward System ◽  
Pathophysiological Role ◽  
The Us ◽  
Goal Directed Behavior ◽  
Economic Choices

A biological reward system is integral to all animal life and humans are no exception. For millennia individuals have investigated this system and its influences on human behavior. In the modern day, with the US facing an ongoing epidemic of substance use without an effective treatment, these investigations are of paramount importance. It is well known that basal ganglia contribute to rewards and are involved in learning, approach behavior, economic choices, and positive emotions. This review aims to elucidate the physiological role of striatonigrostriatal (SNS) spirals, as part of basal ganglia circuits, in this reward system and their pathophysiological role in perpetuating addiction. Additionally, the main functions of neurotransmitters such as dopamine and glutamate and their receptors in SNS circuits will be summarized. With this information, the claim that SNS spirals are crucial intermediaries in the shift from goal-directed behavior to habitual behavior will be supported, making this circuit a viable target for potential therapeutic intervention in those with substance use disorders.

scholarly journals Indirect pathway from caudate tail mediates rejection of bad objects in periphery

2019 ◽  
Vol 5 (8) ◽  
pp. eaaw9297 ◽  
Author(s):  
Hidetoshi Amita ◽  
Okihide Hikosaka
Keyword(s):  
Basal Ganglia ◽  
Choice Task ◽  
Inhibitory Influence ◽  
Indirect Pathway ◽  
Crucial Component ◽  
Rejection Mechanism ◽  
Everyday Task ◽  
Goal Directed Behavior ◽  
Globus Pallidus Externus

The essential everyday task of making appropriate choices is a process controlled mainly by the basal ganglia. To this end, subjects need not only to find “good” objects in their environment but also to reject “bad” objects. To reveal this rejection mechanism, we created a sequential saccade choice task for monkeys and studied the role of the indirect pathway from the CDt (tail of the caudate nucleus) mediated by cvGPe (caudal-ventral globus pallidus externus). Neurons in cvGPe were typically inhibited by the appearance of bad objects; however, this inhibition was reduced on trials when the monkeys made undesired saccades to the bad objects. Moreover, disrupting the inhibitory influence of CDt on cvGPe by local injection of bicuculline (GABAA receptor antagonist) impaired the monkeys’ ability to suppress saccades to bad objects. Thus, the indirect pathway mediates the rejection of bad choices, a crucial component of goal-directed behavior.

Disrupted Salience and Cingulo-Opercular Network Connectivity During Impaired Rapid Instructed Task Learning in Schizophrenia

2021 ◽  
pp. 216770262095934
Author(s):  
Julia M. Sheffield ◽  
Holger Mohr ◽  
Hannes Ruge ◽  
Deanna M. Barch
Keyword(s):  
A Priori ◽  
Network Connectivity ◽  
Task Learning ◽  
Human Ability ◽  
Functional Brain Networks ◽  
Task Goals ◽  
Multivariate Pattern ◽  
And Control ◽  
Goal Directed Behavior

Rapid instructed task learning (RITL) is the uniquely human ability to transform task information into goal-directed behavior without relying on trial-and-error learning. RITL is a core cognitive process supported by functional brain networks. In patients with schizophrenia, RITL ability is impaired, but the role of functional network connectivity in these RITL deficits is unknown. We investigated task-based connectivity of eight a priori network pairs in participants with schizophrenia ( n = 29) and control participants ( n = 31) during the performance of an RITL task. Multivariate pattern analysis was used to determine which network connectivity patterns predicted diagnostic group. Of all network pairs, only the connectivity between the cingulo-opercular network (CON) and salience network (SAN) during learning classified patients and control participants with significant accuracy (80%). CON-SAN connectivity during learning was significantly associated with task performance in participants with schizophrenia. These findings suggest that impaired interactions between identification of salient stimuli and maintenance of task goals contributes to RITL deficits in participants with schizophrenia.

scholarly journals Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lei Xiao ◽  
Devin P. Merullo ◽  
Therese M. I. Koch ◽  
Mou Cao ◽  
Marissa Co ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Basal Ganglia ◽  
Dopamine Receptor ◽  
Speech Disorders ◽  
Receptor Expression ◽  
Vocal Development ◽  
Motor Actions

AbstractDisruption of the transcription factor FoxP2, which is enriched in the basal ganglia, impairs vocal development in humans and songbirds. The basal ganglia are important for the selection and sequencing of motor actions, but the circuit mechanisms governing accurate sequencing of learned vocalizations are unknown. Here, we show that expression of FoxP2 in the basal ganglia is vital for the fluent initiation and termination of birdsong, as well as the maintenance of song syllable sequencing in adulthood. Knockdown of FoxP2 imbalances dopamine receptor expression across striatal direct-like and indirect-like pathways, suggesting a role of dopaminergic signaling in regulating vocal motor sequencing. Confirming this prediction, we show that phasic dopamine activation, and not inhibition, during singing drives repetition of song syllables, thus also impairing fluent initiation and termination of birdsong. These findings demonstrate discrete circuit origins for the dysfluent repetition of vocal elements in songbirds, with implications for speech disorders.

Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons

2008 ◽  
Vol 99 (6) ◽  
pp. 2985-2997 ◽  
Author(s):  
Kay Thurley ◽  
Walter Senn ◽  
Hans-Rudolf Lüscher
Keyword(s):  
Working Memory ◽  
Neuronal Excitability ◽  
Pyramidal Neurons ◽  
D1 Receptors ◽  
Input Output ◽  
Prefrontal Cortical ◽  
Noisy Input ◽  
Relationship Of

Dopaminergic modulation of prefrontal cortical activity is known to affect cognitive functions like working memory. Little consensus on the role of dopamine modulation has been achieved, however, in part because quantities directly relating to the neuronal substrate of working memory are difficult to measure. Here we show that dopamine increases the gain of the frequency-current relationship of layer 5 pyramidal neurons in vitro in response to noisy input currents. The gain increase could be attributed to a reduction of the slow afterhyperpolarization by dopamine. Dopamine also increases neuronal excitability by shifting the input-output functions to lower inputs. The modulation of these response properties is mainly mediated by D1 receptors. Integrate-and-fire neurons were fitted to the experimentally recorded input-output functions and recurrently connected in a model network. The gain increase induced by dopamine application facilitated and stabilized persistent activity in this network. The results support the hypothesis that catecholamines increase the neuronal gain and suggest that dopamine improves working memory via gain modulation.

The role of the basal ganglia in motivated behavior

2012 ◽  
Vol 23 (5-6) ◽  
Author(s):  
Claudio Da Cunha ◽  
Alexander Gomez-A ◽  
Charles D. Blaha
Keyword(s):  
Basal Ganglia ◽  
Motivated Behavior
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