Classical Conditioning: Still Going Strong

1991 ◽  
Vol 19 (1) ◽  
pp. 59-79 ◽  
Author(s):  
Marcel van den Hout ◽  
Harald Merckelbach

This paper summarizes developments in the field of classical conditioning. Attention is paid to four common misconceptions of what is classical conditioning. First, classical conditioning does not ensue as a simple result of temporal pairing of conditioned and unconditioned stimuli. Rather, conditioned reacting occurs if and to the degree that the subject is able to predict the occurrence of one stimulus from the presence of another one. Second, what is learned during classical conditioning is not necessarily a response to a cue, but rather a probabilistic relationship between various stimuli. Third, classical conditioning is not only manifested in responses mediated by the autonomic nervous system, but also in immunological parameters, in motoric behaviour and in evaluative judgments. Fourth, the nature of the conditioned and the unconditioned stimulus is (often) not a matter of indifference: particular combinations of CS and US produce more powerful conditioning effects than do other combinations. In the second part of the paper, the potential relevance of these developments is illustrated. Discussions are included about anxiety, addictions and food aversions/conditioned nausea.

1946 ◽  
Vol 92 (386) ◽  
pp. 146-149
Author(s):  
F. Reitman

Since the influence of the autonomic nervous system on epileptic phenomena became the subject of intensive investigations, several contradictory reports have been published. Williams and Russell (1941) and Williams (1941) found that parasympathetic overactivity (induced chemically and registered by electro-encephalography) increases epileptic activity. Darrow (1944) reported opposite results, his observations being based on electrically induced parasympathetic overactivity on animals. He registered his observations by electroencephalography. Cohen, Thale and Tissenbaum (1044) induced convulsions for therapeutical purposes by administering the parasympathomimetic drug, acetylcholine, and Chatfield and Dempsey (1942) observed the production of fits in cats, when giving acetylcholine and prostigmine together. Though the results were contradictory, the main aim of all these investigations was to establish the cholinergic neurohumoral changes in relation to epilepsy. But, as Williams pointed out, it is impossible to say whether the results are due to a direct central action, are consequent upon changes in the pH or of a respiratory or a circulatory nature. The investigations described in this paper were devised to re-examine these problems clinically. They were based on the hypothesis that if cholinergic overactivity enhances epileptic cerebral activity, the convulsive threshold of the brain should be lowered after administration of anticholinesterases, in particular prostigmine.


Author(s):  
Peggy Mason

Three common misconceptions regarding homeostasis are dispelled. First, the brain has the unique ability to mount an anticipatory defense against changes that could potentially push the body’s physiology out of homeostatic range. Such anticipation of needed adjustments is contrasted to the model of homeostasis as a servomechanism. Second, homeostasis depends on many neurons, not just those in the hypothalamus. Yet hypothalamic neurons play a special role in the integration of challenges and coordination of diverse effector reactions. Third, the idea that homeostasis is the purview of the autonomic nervous system is corrected. As exemplified by respiration and micturition, the brain employs skeletal muscle as well as autonomic targets in supporting visceral life. Finally, the allostatic perspective on the brain’s contribution to staying alive is contrasted with the standard homeostatic perspective and illustrated by examples.


CNS Spectrums ◽  
1999 ◽  
Vol 4 (11) ◽  
pp. 42-48
Author(s):  
Joseph M. Bebchuk ◽  
Manuel E. Tancer

AbstractSocial phobia is an anxiety disorder that is characterized by excessive fear and/or avoidance of situations in which an individual believes that he or she may be the subject of evaluation or scrutiny while interacting with other people or performing a specific task. This article reviews the available literature on the neurobiology underlying social phobia, including autonomic nervous system effects, neuroimaging findings, pharmacologic challenge studies, and neuroendocrine responsivity and function. Overall, such studies have found few consistently demonstrable differences in neurobiology between patients with social phobia and healthy controls, but further investigations are needed.


Author(s):  
Albert Flotats ◽  
Ignasi Carrió

Cardiac autonomic nervous system contributes to maintain haemodynamic and electrophysiological stability to changing demands. Cardiac innervation imaging can be performed by means of planar scintigraphy/SPECT or PET using different radiotracers developed for the assessment of pre- and postsynaptic receptors of the cardiac autonomic nervous system, with sufficient sensitivity to assess a process that takes place at picomolar concentrations. Clinically, cardiac innervation imaging is mainly performed targeting postganglionic presynaptic sympathetic neurons by means of myocardial 123I-metaiodobenzylguanidine (123I-mIBG) planar scintigraphy and SPECT, which has shown to be of value in the assessment of patients with different cardiac disorders, especially in those with heart failure (HF), having an independent prognostic value. This clinically oriented chapter updates the subject with inclusion of new data reinforcing the use of sympathetic cardiac innervation imaging for improving patient management.


2021 ◽  
pp. 243-252
Author(s):  
Yaron Ilan

Background: Control of chronic pain and mainly the partial or complete loss of response to analgesics is a major unmet need. Multiple mechanisms underline the development of tolerance to analgesics in general and specifically to opioids. The autonomic nervous system (ANS) plays a role in the development of analgesic tolerance and chronobiology. Objectives: To review the mechanisms associated with the development of nonresponsiveness to analgesics. Study Design: Literature review. Setting: The review is followed by a description of a new method for overcoming resistance and improving the response to analgesics. Methods: Conducted a detailed review of the relevant studies describing the mechanisms that underlie tolerance to pain medications, and the potential roles of the ANS and chronobiology in the development of drug resistance. Results: The autonomic balance is reflected by heart rate variability, an example of a fundamental variability that characterizes biological systems. Chronotherapy, which is based on the circadian rhythm, can improve the efficacy and reduce the toxicity of chronic medications. In this article, we present the establishment of an individualized variability- and chronobiology-based therapy for overcoming the compensatory mechanisms associated with a loss of response to analgesics. We describe the premise of implementing personalized signatures associated with the ANS, and chronobiology, as well as with the pathophysiology of pain for establishing an adaptive model that could improve the efficacy of opioids, in a highly dynamic system. Limitations: The studies presented were selected based on their relevance to the subject. Conclusions: The described variability-based system may ensure prolonged effects of analgesics while reducing the toxicity associated with increasing dosages. Key words: Painkillers, opioids, drug resistance, compensatory mechanisms


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