Serotype distribution and antibiotic susceptibility of group B streptococci in pregnant women

2009 ◽  
Vol 138 (7) ◽  
pp. 979-981 ◽  
Author(s):  
A. DHANOA ◽  
R. KARUNAKARAN ◽  
S. D. PUTHUCHEARY
Keyword(s):  
Pregnant Women ◽  
Neonatal Sepsis ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Prevention Strategies ◽  
Serotype Distribution ◽  
Group B Streptococci ◽  
Birth Canal ◽  
Group B

SUMMARYGroup B streptococcus (GBS) is a leading cause of neonatal sepsis and is usually acquired via the woman's birth canal. GBS serotypes isolated from 200 pregnant women were determined. Serotypes V (19%) and VI (17%) were the most frequent followed by serotypes III (12%), Ia (11·5%) and IV (10%); 17% of the strains were non-typable. All isolates were susceptible to penicillin, 96% to erythromycin and 97·5% to clindamycin. The emergence of new GBS serotypes has important implications for vaccine prevention strategies.

scholarly journals Group B streptococcus colonization, antibiotic susceptibility, and serotype distribution among Saudi pregnant women

2020 ◽  
Vol 52 (1) ◽  
pp. 70
Author(s):  
Amr Mohamed Mohamed ◽  
Mubashir Ahmad Khan ◽  
Aftab Faiz ◽  
Jawwad Ahmad ◽  
Elsheikh Babiker Khidir ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Serotype Distribution ◽  
Group B

scholarly journals Antibiotic susceptibility pattern of group B streptococcal isolates from maternal genital tract

2019 ◽  
Vol 8 (7) ◽  
pp. 2738
Author(s):  
Vijayan Sharmila ◽  
Thirunavukkarasu Arun Babu
Keyword(s):  
Pregnant Women ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Antibiotic Sensitivity ◽  
Developed Countries ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Sensitivity Pattern ◽  
Prevention And Treatment ◽  
Group B

Background: Group B streptococcus (GBS) is one of the important cause of early onset neonatal sepsis in developed countries leading to increased neonatal morbidity and mortality. Penicillin and Ampicillin are the drugs of choice for prevention of GBS infections. Antibiotic resistance amongst GBS isolates is an emerging health problem affecting neonates. Hence, this study was performed to determine the antibiotic susceptibility pattern of Group B Streptococcus (GBS) in a population of pregnant women.Methods: A prospective study was done to screen pregnant women for vaginal and rectal GBS colonization during their regular visits to antenatal clinic. Todd-Hewitt broth, an enrichment medium for GBS was used for isolation. The antibiotic susceptibility pattern of the isolates were studied.  Results: A total of 300 pregnant women were screened for GBS colonization. GBS colonization rate in our study was 2.3%. The antibiotic susceptibility pattern of the isolates revealed that none of the isolates were resistant to penicillin or clindamycin, while resistance was noted to erythromycin (14.3%) and   tetracycline (71.4%).Conclusions: GBS continues to remain sensitive to Penicillin which is the drug of choice for prevention and treatment of GBS.  Consistent surveillance of antibiotic sensitivity pattern of GBS as well as for other organisms implicated in new born sepsis and maternal infections is required to formulate guidelines for prevention and treatment.

scholarly journals Prevalence of Group B Streptococcus Colonization in Pregnant Women in Jiangsu, East China

2019 ◽  
Author(s):  
Rui Wang ◽  
Hongmei Qiu ◽  
Ge Yanmei ◽  
Fei Pan ◽  
Shuhui Bian
Keyword(s):  
Pregnant Women ◽  
Antimicrobial Susceptibility ◽  
Neonatal Sepsis ◽  
Susceptibility Testing ◽  
Bacterial Culture ◽  
Group B Streptococcus ◽  
East China ◽  
Age Group ◽  
The Difference ◽  
Group B

Abstract Background : Group B streptococcus (GBS) is the leading cause of early-onset neonatal sepsis. This study assessed the prevalence of GBS colonization among pregnant women in Jiangsu, East China. Methods: A total of 16,184 pregnant women at 34 to 37 weeks , gestation aged 16–47 years were recruited from Nanjing Kingmed Diagnostics, including 9022 pregnant women who received GBS screening by PCR detection and 7162 by bacterial culture, antimicrobial susceptibility testing was performed on GBS positive samples. Results: The overall GBS prevalence was 8.7% for pregnant women studied by PCR and 3.5% by culture. The 25-29 age group had the highest rate of GBS colonization in the pregnant women. The prevalence of resistance to erythromycin, clindamycin and levofloxacin was 77.5%, 68.3% and 52.2%, respectively. Conclusions: This study revealed the prevalence characteristics of GBS in pregnant women and the difference of GBS colonization between culture and PCR in Jiangsu province.

scholarly journals Group B Streptococcus colonization rate and serotype distribution among pregnant women and their newborns at Adama Hospital Medical College, Ethiopia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Musa Mohammed Ali ◽  
Daniel Asrat ◽  
Demissie Assegu Fenta ◽  
Tolossa Eticha Chaka ◽  
Yimtubezinash Woldeamanuel
Keyword(s):  
Pregnant Women ◽  
Group B Streptococcus ◽  
Colonization Rate ◽  
Serotype Distribution ◽  
Medical College ◽  
Hospital Medical ◽  
Group B

scholarly journals Group B Streptococcus colonization in pregnancy: prevalence and prevention strategies of neonatal sepsis

2009 ◽  
Vol 37 (2) ◽  
Author(s):  
Alma-Verena Rausch ◽  
Ariane Gross ◽  
Sara Droz ◽  
Thomas Bodmer ◽  
Daniel V. Surbek
Keyword(s):  
Neonatal Sepsis ◽  
Group B Streptococcus ◽  
Prevention Strategies ◽  
Group B ◽  
In Pregnancy

scholarly journals Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study

2019 ◽  
Vol 23 (67) ◽  
pp. 1-40 ◽  
Author(s):  
Clara Carreras-Abad ◽  
Madeleine Cochet ◽  
Tom Hall ◽  
Laxmee Ramkhelawon ◽  
Asma Khalil ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Feasibility Study ◽  
Group B Streptococcus ◽  
Serotype Distribution ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Group B Streptococcal Disease ◽  
Intrapartum Antibiotic ◽  
Group B ◽  
Operational Aspects

Background Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease. However, intrapartum antibiotic prophylaxis does not prevent maternal sepsis, premature births, stillbirths or late-onset disease. Maternal vaccination may offer an alternative strategy. Multivalent polysaccharide protein conjugate vaccine development is under way and a serocorrelate of protection is needed to expedite vaccine licensure. Objectives The ultimate aim of this work is to determine the correlate of protection against the major group B streptococcus disease-causing serotypes in infants in the UK. The aim of this feasibility study is to test key operational aspects of the study design. Design Prospective cohort study of pregnant women and their infants in a 6-month period (1 July to 31 December 2018). Setting Five secondary and tertiary hospitals from London and South England. National iGBS disease surveillance was conducted in all trusts in England and Wales. Participants Pregnant women aged ≥ 18 years who were delivering at one of the selected hospitals and who provided consent during the study period. There were no exclusion criteria. Interventions No interventions were performed. Main outcome measures (1) To test the feasibility of collecting serum at delivery from a large cohort of pregnant women. (2) To test the key operational aspects for a proposed large serocorrelates study. (3) To test the feasibility of collecting samples from those with invasive group B streptococcus. Results A total of 1823 women were recruited during the study period. Overall, 85% of serum samples were collected at three sites collecting only cord blood. At the two sites collecting maternal, cord and infant blood samples, the collection rate was 60%. A total of 614 women were screened for group B streptococcus with a colonisation rate of 22% (serotype distribution: 30% III, 25% Ia, 16% II, 14% Ib, 14% V and 1% IV). A blood sample was collected from 34 infants who were born to colonised women. Maternal and infant blood and the bacterial isolates for 15 newborns who developed invasive group B streptococcal disease during the study period were collected (serotype distribution: 29% III, 29% II, 21% Ia, 7% Ib, 7% IV and 7% V). Limitations Recruitment and sample collection were dependent on the presence of research midwives rather than the whole clinical team. In addition, individualised consent limited the number of women who could be approached each day, and site set-up for the national surveillance study and the limited time period of this feasibility study limited recruitment of all eligible participants. Conclusions We have verified the feasibility of collecting and processing rectovaginal swabs and blood samples in pregnant women, as well as samples from those with invasive group B streptococcal disease. We have made recommendations for the recruitment of cases within the proposed GBS3 study and for controls both within GBS3 and as an extension of this feasibility study. Future work A large case–control study comparing specific immunoglobulin G levels in mothers whose infants develop invasive group B streptococcal disease with those in colonised mothers whose infants do not develop invasive group B streptococcal disease is recommended. Trial registration Current Controlled Trials ISRCTN49326091; IRAS project identification number 246149/REC reference number 18/WM/0147. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 67. See the NIHR Journals Library website for further project information.

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