Comparing the impact of two concurrent infectious disease outbreaks on The Netherlands population, 2009, using disability-adjusted life years

SUMMARYIn 2009 two notable outbreaks, Q fever and the novel influenza A(H1N1)pdm09, occurred in The Netherlands. Using a composite health measure, disability-adjusted life years (DALYs), the outbreaks were quantified and compared. DALYs were calculated using standardized methodology incorporating age- and sex-stratified data in a disease progression model; years lost due to disability and years of life lost were computed by outcome. Nationally, influenza A(H1N1)pdm09 caused more DALYs (24 484) than Q fever (5797). However, Q fever was 8·28 times more severe [497 DALYs/1000 symptomatic cases (DP1SC)] than A(H1N1)pdm09 (60 DP1SC). The A(H1N1)pdm09 burden is largely due to mortality while the Q fever burden is due primarily to long-term sequelae. Intervention prioritization for influenza should support patients in a critical condition while for Q fever it should target immediate containment and support for patients with long-term sequelae. Burden estimates provide guidance for focusing intervention options during outbreaks of infectious diseases.

Download Full-text

Disability-adjusted Life Years for respiratory syncytial virus in children under 2 years

10.21203/rs.3.rs-20260/v3 ◽

2020 ◽

Author(s):

jefferson buendia ◽

Fernando Polack ◽

Juana Patricia Sanchez Villamil

Keyword(s):

Respiratory Syncytial Virus ◽

Statistical Parameter ◽

Epidemiological Surveillance ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Disability Adjusted Life ◽

Life Years ◽

Rsv Infection ◽

Syncytial Virus ◽

The Impact

Abstract BACKGROUND: Respiratory syncytial virus infection is the leading cause of bronchiolitis in Colombia. There is growing evidence about the impact of Respiratory syncytial virus on society in terms of years of life lost due to this condition. The objective of the present study is to determine the Disability-Adjusted Life Years for respiratory syncytial virus in children under 2 years in ColombiaMETHODS: Data from the national epidemiological surveillance system were used to estimate DALYs, calculated from the sum of years of life lost and years lived with disability due to RSV infection in Colombia. A bootstrapped method with 10000 iterations was used to estimate each statistical parameter using the package DALY calculator in R. RESULTS: In 2019, 260 873 years of life (CI95% 208 180- 347 023) were lost due to RSV bronchiolitis in Colombian children under 2 years. The estimated rate was 20 DALYs / 1000 person-year (95% CI 16 – 27).CONCLUSION: This is the first report estimating the impact of RSV bronchiolitis morbidity and mortality in Colombia. The findings of the present study suggest that the actual burden and cost of bronchiolitis due to RSV is high. Prevention strategies, such as RSV vaccination, to reduce morbidity associated with RSV infection should be encouraged in our country.

Download Full-text

Estimating Disability-Adjusted Life Years (DALYs) in Community Cases of Norovirus in England

Viruses ◽

10.3390/v11020184 ◽

2019 ◽

Vol 11 (2) ◽

pp. 184

Author(s):

John P Harris ◽

Miren Iturriza-Gomara ◽

Sarah J O’Brien

Keyword(s):

Gastrointestinal Diseases ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Healthy Life ◽

England And Wales ◽

Infected People ◽

Disability Adjusted Life ◽

Life Years ◽

Years Lived With Disability

Disability adjusted life years (DALYs) have been used since the 1990s. It is a composite measure of years of life lost with years lived with disability. Essentially, one DALY is the equivalent of a year of healthy life lost if a person had not experienced disease. Norovirus is the most common cause of gastrointestinal diseases worldwide. Norovirus activity varies from one season to the next for reasons not fully explained. Infection with norovirus is generally not severe, and is normally characterized as mild and self-limiting with no long-term sequelae. In this study, we model a range of estimates of DALYs for community cases of norovirus in England and Wales. We estimated a range of DALYs for norovirus to account for mixing of the severity of disease and the range of length of illness experienced by infected people. Our estimates were between 1159 and 4283 DALYs per year, or 0.3–1.2 years of healthy life lost per thousand cases of norovirus. These estimates provide evidence that norovirus leads to a considerable level of ill health in England and Wales. This information will be helpful should candidate norovirus vaccines become available in the future.

Download Full-text

Cancers Attributable to Obesity in Indonesia: A Prevalence Based Study Using Disability Adjusted Life Years

Global Journal of Health Science ◽

10.5539/gjhs.v10n8p21 ◽

2018 ◽

Vol 10 (8) ◽

pp. 21

Author(s):

Galih Wulandari ◽

Susi Kristina

Keyword(s):

Colorectal Cancer ◽

Pancreatic Cancer ◽

Relative Risk ◽

Kidney Cancer ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Female Population ◽

Disability Adjusted Life ◽

Life Years ◽

The Impact

The prevalence of obesity in the world has nearly tripled since 1975. Obesity clearly known as risk factor for various diseases, including many types of cancer. This study aims to determine the obesity attributable fraction (OAF) of seven cancers based on the relative risk of esophageal cancer, colorectal, pancreatic, endometrial, ovarian, prostate and kidney cancer and also to estimate the burden of cancer caused by obesity with disability adjusted life years (DALY) indicator. This study is a descriptive epidemiological study with prevalence-based method, which the prevalence data obtained from Indonesian National Health Insurance (BPJS) 2016. The OAF is calculated by combining both data of obesity prevalence and relative risk and the DALY indicator is calculated as the sum of years of life lost due to premature mortality (YLL) and the equivalent healthy years lost due to disability (YLD). Based on OAF calculation, three highest proportions OAF in men were in colorectal cancer (6.02%), kidney (4.91%) and pancreatic cancer (4.55%), while in women were from kidney cancer (13.92%), endometrial (12.63%) and colorectal cancer (7.49%). Meanwhile the burden priorities of cancer by obesity in Indonesia were come from colon cancer (23,051), ovarian cancer (21.911), and pancreatic cancer (4,564). Burden of cancer attributable to obesity in Indonesia mostly related to digestive organ and high prevalence in female population. It is the impact of life changes and less activity due to globalization. All cancers attributable to obesity should be considered and have to controlled by the government through health programs and policies.

Download Full-text

Disability-adjusted Life Years for respiratory syncytial virus in Colombian children.

10.21203/rs.3.rs-20260/v1 ◽

2020 ◽

Author(s):

jefferson buendia ◽

Fernando Polack ◽

Juana Patricia Sanchez Villamil

Keyword(s):

Respiratory Syncytial Virus ◽

Statistical Parameter ◽

Epidemiological Surveillance ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Disability Adjusted Life ◽

Life Years ◽

Rsv Infection ◽

Syncytial Virus ◽

The Impact

Abstract BACKGROUND Respiratory syncytial virus infection is the leading cause of bronchiolitis worldwide. However, little is known about the real impact of bronchiolitis on society in terms of years of life lost due to this condition. The objective of the present study is to determine the Disability-Adjusted Life Years (1) in ColombiaMETHODS Data from the national epidemiological surveillance system were used to estimate DALYs, calculated from the sum of years of life lost and years lived with disability due to RSV infection in Colombia. A bootstrapped method with 10000 iterations was used to estimate each statistical parameter using the package DALY calculator in R.RESULTS In 2019, 260 873 years of life (IC 95% 208 180–347 023) were lost due to RSV bronchiolitis in Colombian children under 2 years. The estimated rate was 20 DALYs / 1000 person-year (95% CI 16–27).CONCLUSION This is the first report estimating the impact of RSV bronchiolitis morbidity and mortality in Colombia. The findings of the present study suggest that the actual burden and cost of bronchiolitis due to RSV is high. Prevention strategies to reduce morbidity associated with RSV infection should be encouraged in our country.

Download Full-text

Estimation of the economic burden of COVID-19 using disability-adjusted life years (DALYs) and productivity losses in Kerala, India: a model-based analysis

BMJ Open ◽

10.1136/bmjopen-2021-049619 ◽

2021 ◽

Vol 11 (8) ◽

pp. e049619

Author(s):

Denny John ◽

M S Narassima ◽

Jaideep Menon ◽

Jammy Guru Rajesh ◽

Amitava Banerjee

Keyword(s):

Economic Burden ◽

Premature Mortality ◽

Secondary Outcome ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Model Based ◽

Disability Adjusted Life ◽

Life Years ◽

The Impact ◽

Model Based Analysis

ObjectivesFrom the beginning of the COVID-19 pandemic, clinical practice and research globally have centred on the prevention of transmission and treatment of the disease. The pandemic has had a huge impact on the economy and stressed healthcare systems worldwide. The present study estimates disability-adjusted life years (DALYs), years of potential productive life lost (YPPLL) and cost of productivity lost (CPL) due to premature mortality and absenteeism secondary to COVID-19 in the state of Kerala, India.SettingDetails on sociodemographics, incidence, death, quarantine, recovery time, etc were derived from public sources and the Collective for Open Data Distribution-Keralam. The working proportion for 5-year age–gender cohorts and the corresponding life expectancy were obtained from the 2011 Census of India.Primary and secondary outcome measuresThe impact of the disease was computed through model-based analysis on various age–gender cohorts. Sensitivity analysis was conducted by adjusting six variables across 21 scenarios. We present two estimates, one until 15 November 2020 and later updated to 10 June 2021.ResultsSeverity of infection and mortality were higher among the older cohorts, with men being more susceptible than women in most subgroups. DALYs for males and females were 15 954.5 and 8638.4 until 15 November 2020, and 83 853.0 and 56 628.3 until 10 June 2021. The corresponding YPPLL were 1323.57 and 612.31 until 15 November 2020, and 6993.04 and 3811.57 until 10 June 2021, and the CPL (premature mortality) were 263 780 579.94 and 41 836 001.82 until 15 November 2020, and 1 419 557 903.76 and 278 275 495.29 until 10 June 2021.ConclusionsMost of the COVID-19 burden was contributed by years of life lost. Losses due to YPPLL were reduced as the impact of COVID-19 infection was lesser among the productive cohorts. The CPL values for individuals aged 40–49 years old were the highest. These estimates provide the data necessary for policymakers to work on reducing the economic burden of COVID-19 in Kerala.

Download Full-text

Disability-adjusted Life Years for respiratory syncytial virus in children under 2 years

10.21203/rs.3.rs-20260/v5 ◽

2020 ◽

Author(s):

Juana Patricia Sanchez Villamil ◽

Fernando Polack ◽

jefferson buendia

Keyword(s):

Respiratory Syncytial Virus ◽

Statistical Parameter ◽

Epidemiological Surveillance ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Disability Adjusted Life ◽

Life Years ◽

Rsv Infection ◽

Syncytial Virus ◽

The Impact

Abstract BACKGROUND : Respiratory syncytial virus infection is the leading cause of bronchiolitis in Colombia. There is growing evidence about the impact of Respiratory syncytial virus on society in terms of years of life lost due to this condition. The objective of the present study is to determine the Disability-Adjusted Life Years for respiratory syncytial virus in children under 2 years in Colombia METHODS : Data from the national epidemiological surveillance system were used to estimate DALYs, calculated from the sum of years of life lost and years lived with disability due to RSV infection in Colombia. A bootstrapped method with 10000 iterations was used to estimate each statistical parameter using the package DALY calculator in R. RESULTS : In 2019, 260 873 years of life (CI95% 208 180- 347 023) were lost due to RSV bronchiolitis in Colombian children under 2 years. The estimated rate was 20 DALYs / 1000 person-year (95% CI 16 – 27). CONCLUSION : This is the first report estimating the impact of RSV bronchiolitis morbidity and mortality in Colombia. The findings of the present study suggest that the actual burden and cost of bronchiolitis due to RSV is high. Prevention strategies, such as RSV vaccination, to reduce morbidity associated with RSV infection should be encouraged in our country.

Download Full-text

Disability-adjusted Life Years for respiratory syncytial virus in children under 2 years

10.21203/rs.3.rs-20260/v4 ◽

2020 ◽

Author(s):

Juana Patricia Sanchez Villamil ◽

Fernando Polack ◽

Jefferson Buendia

Keyword(s):

Respiratory Syncytial Virus ◽

Statistical Parameter ◽

Epidemiological Surveillance ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Disability Adjusted Life ◽

Life Years ◽

Rsv Infection ◽

Syncytial Virus ◽

The Impact

Download Full-text

The estimated disease burden of acute COVID-19 in the Netherlands in 2020, in disability-adjusted life-years

10.21203/rs.3.rs-1026794/v1 ◽

2021 ◽

Author(s):

Scott A. McDonald ◽

Giske R. Lagerweij ◽

Pieter de Boer ◽

Hester E. de Melker ◽

Roan Pijnacker ◽

...

Keyword(s):

Public Health ◽

The Netherlands ◽

Disease Burden ◽

Years Of Life Lost ◽

Age Group ◽

Disability Adjusted Life Years ◽

Health Burden ◽

Disability Adjusted Life ◽

Life Years ◽

Per Capita

Abstract Background. The impact of the COVID-19 pandemic on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or intensive care unit (ICU) admission, results in prolonged and chronic illness, or leads to premature death. Our objectives were to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how disease burden varies between age-groups and occupation categories.Methods. Using standard methods and diverse data sources (registered COVID-19 deaths, hospital and ICU admissions, population-level seroprevalence, mandatory notifications, and the literature) , we estimated the total years of life lost (YLL), years lived with disability (YLD), DALY and DALY per 100,000 population due to COVID-19, excluding its post-acute sequelae, and additionally stratified by 5-year age-group and occupation.Results. The total disease burden in the Netherlands in 2020 due to acute COVID-19 was 273,500 (95% CI: 268,500–278,800) DALY, and the per-capita burden was 1570 (95% CI: 1540–1600) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from the 60-64 years age-group. The per-capita burden by occupation category was highest for healthcare workers and lowest for the catering sector.Conclusions. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. Total DALY were much higher than for other high-burden infectious diseases, but lower than the estimated annual burden from coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected health burden due to COVID-19 among subgroups of the population, and the possible gains from targeted preventative interventions.

Download Full-text

1442The burden of COVID-19 in Australia in 2020

International Journal of Epidemiology ◽

10.1093/ije/dyab168.452 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Lynelle Moon ◽

Anna Reynolds ◽

Michelle Gourley

Keyword(s):

Burden Of Disease ◽

Disease Burden ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Australian Population ◽

Healthy Life ◽

Disability Adjusted Life ◽

Life Years ◽

Years Lived With Disability ◽

The Impact

Abstract Background During 2020, there were nearly 28,500 cases of COVID-19 in Australia. Burden of disease estimates for COVID-19 have not been calculated for the Australian population. Burden of disease data on COVID-19 provide valuable information on the impact of the disease, including both fatal and non-fatal effects. Methods Burden of disease is measured using the summary measure disability-adjusted life years (DALYs). One DALY is 1 year of ‘healthy life’ lost due to illness (Years Lived with Disability) and/or death (Years of Life Lost)—the more DALYs associated with a disease or injury, the greater the burden. The analysis draws on Australian deaths, incidence and severity, as well as methods and other inputs developed in other countries reflecting current understanding about this new disease. Results There were over 8,300 DALYs lost due to COVID-19 in 2020 in Australia; 97% of the disease burden arose from fatal cases. Males lost an average of 10.7 years, and females 8.1 years, due to dying from COVID-19, using an aspirational life expectancy. The burden of disease estimates for Australia for COVID-19 are much lower than the leading diseases causing burden. Conclusions The relatively low burden for COVID-19 in Australia in 2020 compared to other diseases and other countries reflects the success Australia had in containing the virus. Key messages Most of the burden due to COVID-19 in Australia was fatal. Burden of disease estimates for COVID-19 in Australia for 2020 are much lower than the leading diseases.

Download Full-text

Disability-adjusted Life Years for respiratory syncytial virus in children under 2 years

10.21203/rs.3.rs-20260/v2 ◽

2020 ◽

Author(s):

jefferson buendia ◽

Fernando Polack ◽

Juana Patricia Sanchez Villamil

Keyword(s):

Respiratory Syncytial Virus ◽

Statistical Parameter ◽

Epidemiological Surveillance ◽

Years Of Life Lost ◽

Disability Adjusted Life Years ◽

Disability Adjusted Life ◽

Life Years ◽

Rsv Infection ◽

Syncytial Virus ◽

The Impact

Abstract BACKGROUND: Respiratory syncytial virus infection is the leading cause of bronchiolitis worldwide. However, little is known about the real impact of Respiratory syncytial virus on society in terms of years of life lost due to this condition. The objective of the present study is to determine the Disability-Adjusted Life Years for respiratory syncytial virus in children under 2 years in Colombia METHODS: Data from the national epidemiological surveillance system were used to estimate DALYs, calculated from the sum of years of life lost and years lived with disability due to RSV infection in Colombia. A bootstrapped method with 10000 iterations was used to estimate each statistical parameter using the package DALY calculator in R. RESULTS: In 2019, 260 873 years of life (CI95% 208 180- 347 023) were lost due to RSV bronchiolitis in Colombian children under 2 years. The estimated rate was 20 DALYs / 1000 person-year (95% CI 16 – 27). CONCLUSION: This is the first report estimating the impact of RSV bronchiolitis morbidity and mortality in Colombia. The findings of the present study suggest that the actual burden and cost of bronchiolitis due to RSV is high. Prevention strategies, such as RSV vaccination, to reduce morbidity associated with RSV infection should be encouraged in our country.

Download Full-text