Advanced Parental Age: A Risk Factor for Alzheimer's Disease or Depression in the Elderly?

2000 ◽  
Vol 12 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Ursula Ptok ◽  
Andreas Papassotiropoulos ◽  
Wolfgang Maier ◽  
Reinhard Heun
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Control Sample ◽  
The Elderly ◽  
Parental Age ◽  
Family History Information ◽  
Healthy Control ◽  
Study Population ◽  
Depressive Episodes

Background: Advanced parental age has been suggested as a risk factor for Alzheimer's disease (AD) as well as for other psychiatric disorders. In the present investigation, a sample of gerontopsychiatric patients was examined for a possible parental age effect. Study Population and Methods: Eighty-three patients with AD, 154 elderly patients with depressive episodes, and 48 comorbid patients (AD and depressive episode) as well as 107 age-matched healthy control subjects from the general population were included in the investigation. Information on the years of birth of the parents was derived from personal or family history information. Results: The mean maternal and paternal ages at the time of birth of the index subject were not significantly different for the different diagnostic subgroups or for the control sample. Conclusion: There was no evidence in our sample that advanced parental age increases the risk of AD or depression in the elderly.

scholarly journals Obesity and the Ageing Brain: Could Leptin Play a Role in Neurodegeneration?

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
G. H. Doherty
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Human Population ◽  
The Elderly ◽  
Leptin Resistance ◽  
Important Research ◽  
Signalling System ◽  
Beneficial Effects ◽  
Ageing Brain

Obesity and ageing are both characteristics of the human population that are on the increase across the globe. It has long been established that ageing is the major risk factor for neurodegenerative conditions such as Alzheimer's disease, and it is becoming increasingly evident that obesity is another such factor. Leptin resistance or insensitivity has been uncovered as a cause of obesity, and in addition the leptin signalling system is less potent in the elderly. Taken together, these findings reveal that this molecule may be a link between neurodegeneration and obesity or ageing. It is now known that leptin has beneficial effects on both the survival and neurophysiology of the neurons that are lost in Alzheimer's disease suggesting that it may be an important research target in the quest for strategies to prevent, halt, or cure this condition.

Anosognosia in Alzheimer’s disease: The role of impairment levels in assessment of insight across domains

2010 ◽  
Vol 16 (3) ◽  
pp. 463-473 ◽  
Author(s):  
HANNA LEICHT ◽  
MARTIN BERWIG ◽  
HERMANN-JOSEF GERTZ
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuropsychological Tests ◽  
Control Sample ◽  
Self Assessment ◽  
Domain Specific ◽  
Clinical Rating ◽  
Healthy Control ◽  
And Performance

AbstractImpaired insight for deficits (anosognosia) is common in Alzheimer’s disease (AD). However, it has not yet been determined clearly (a) whether different methods for assessing insight are comparable, and (b) whether anosognosia affects different domains to different degrees (domain-specificity). Impaired insight was investigated in 32 patients with AD, who were each accompanied by a caregiver. Anosognosia was assessed by a global clinical rating, questionnaire discrepancies (patient vs. caregiver) covering different domains, and performance discrepancies (self-assessment vs. performance) based on four neuropsychological tests which were compared with those of a healthy control sample. The results of clinical rating and questionnaire discrepancies were closely correlated, but performance discrepancies showed no association with the other methods. Anosognosia was present in the majority of the sample, and occurred across domains. The domains corresponding to core deficits in AD (recent memory, activities of daily living) appeared especially prone to anosognosia. However, results do not suggest that anosognosia itself is domain-specific. Rather, it appears that insight may be invariant, while differences in patient-caregiver discrepancies arise largely from different degrees of deficit across domains. (JINS, 2010, 16, 463–473.)

scholarly journals Association between the APOE ε4 Allele and Late-Onset Alzheimer’s Disease in an Ecuadorian Mestizo Population

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Stefany Montufar ◽  
Cristian Calero ◽  
Rodrigo Vinueza ◽  
Patricio Correa ◽  
Andrea Carrera-Gonzalez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Genetic Risk ◽  
Disease Risk ◽  
Late Onset ◽  
Genetic Risk Factor ◽  
Genotype Frequencies ◽  
Healthy Control ◽  
Genetic Contributions

Alzheimer’s disease (AD) is the most common neurodegenerative disease. It has two main pathological hallmarks: amyloid plaques and neurofibrillary tangles. The APOE ε4 allele has been recognized as the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD) in several populations worldwide, yet the risk varies by region and ethnicity. The aims of this study were to describe APOE allele and genotype frequencies and examine the relationship between the APOE ε4 allele and LOAD risk in an Ecuadorian Mestizo population. We carried out a case-control study comprising 56 individuals clinically diagnosed with probable AD (≥65 years of age) and 58 unrelated healthy control subjects (≥65 years of age). Genotyping was performed using the real-time PCR method. Our data showed that allelic and genotypic frequencies follow the trends observed in most worldwide populations. We also found a high-risk association between APOE ε4 allele carriers and LOAD (OR = 7.286; 95% CI = 2.824–18.799; p<0.001). Therefore, we concluded that APOE ε4 must be considered an important genetic risk factor for LOAD in the Ecuadorian Mestizo population. Additionally, we suggest that in mixed populations the effects of admixture and ethnic identity should be differentiated when evaluating genetic contributions to Alzheimer’s disease risk.

Parental age as a risk factor in Alzheimer's disease

1983 ◽  
Vol 13 (6) ◽  
pp. 674-676 ◽  
Author(s):  
Suzanne Corkin ◽  
John H. Growdon ◽  
Shelley L. Rasmussen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Parental Age

scholarly journals Mild TBI in the elderly – risk factor for rapid cognitive impairment in Alzheimer’s disease

2020 ◽  
Vol 61 (1) ◽  
pp. 61-72 ◽  
Author(s):  
Puiu Olivian Stovicek ◽  
◽  
Carol Friedmann ◽  
Dragoş Marinescu ◽  
Ion Alexandru Văduva ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Cognitive Impairment ◽  
The Elderly ◽  
Mild Tbi

scholarly journals A Pilot Study Evaluating the Contribution ofSLC19A1(RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Fabio Coppedè ◽  
Pierpaola Tannorella ◽  
Gloria Tognoni ◽  
Silvia Bagnoli ◽  
Paolo Bongioanni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Vitamin B12 ◽  
Neurodegenerative Disorder ◽  
The Elderly ◽  
Asian Populations ◽  
Genotype Frequencies ◽  
Italian Origin ◽  
Circulating Levels

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly. Polymorphisms of genes involved in folate metabolism have been frequently suggested as risk factors for sporadic AD. A common c.80G>A polymorphism (rs1051266) in the gene coding for the reduced folate carrier (SLC19A1gene, commonly known asRFC-1gene) was investigated as AD risk factor in Asian populations, yielding conflicting results. We screened a Caucasian population of Italian origin composed of 192 sporadic AD patients and 186 healthy matched controls, for the presence of theRFC-1c.80G>A polymorphism, and searched for correlation with circulating levels of folate, homocysteine, and vitamin B12. No difference in the distribution of allele and genotype frequencies was observed between AD patients and controls. No correlation was observed among the genotypes generated by theRFC-1c.80G>A polymorphism and circulating levels of folate, homocysteine, and vitamin B12 either in the whole cohort of subjects or after stratification into clinical subtypes. Present results do not support a role for theRFC-1c.80G>A polymorphism as independent risk factor for sporadic AD in Italian Caucasians.

scholarly journals Alteredβ-Amyloid Precursor Protein Isoforms in Mexican Alzheimer’s Disease Patients

2006 ◽  
Vol 22 (3) ◽  
pp. 119-125 ◽  
Author(s):  
V. J. Sánchez-González ◽  
G. G. Ortiz ◽  
P. Gallegos-Arreola ◽  
M. A. Macías-Islas ◽  
E. D. Arias-Merino ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Protein Isoforms ◽  
Control Subjects ◽  
High Risk Factor ◽  
Healthy Control ◽  
App Ratio

Objective: To determine theβ-amyloid precursor protein (βAPP) isoforms ratio as a risk factor for Alzheimer’s Disease and to assess its relationship with demographic and genetic variables of the disease.Methods: Blood samples from 26 patients fulfilling NINCDS-ADRDA diagnostic criteria for AD and 46 healthy control subjects were collected for Western blotting forβAPP. A ratio ofβAPP isoforms, in optical densities, between the upper band (130 Kd) and the lower bands (106–110 Kd) was obtained. Odds ratios were obtained to determine risk factor of this component.Results:βAPP ratio on AD subjects was lower than that of control subjects: 0.3662 ± 0.1891 vs. 0.6769 ± 0.1021 (mean ± SD, p<0.05). A lowβAPP ratio (<0.6) showed an OR of 4.63 (95% CI 1.45 ± 15.33). When onset of disease was taken into account, aβAPP ratio on EOAD subjects of 0.3965 ± 0.1916 was found vs. 0.3445 ± 0.1965 on LOAD subjects (p>0.05).Conclusions: AlteredβAPP isoforms is a high risk factor for Alzheimer’s disease, although it has no influence on the time of onset of the disease.

scholarly journals Association of Serum Magnesium Concentration with Alzheimer’s Disease

2017 ◽  
Vol 33 (2) ◽  
pp. 70-75
Author(s):  
Mohammad Kafil Uddin ◽  
Md Ahsan Habib ◽  
Md Rafiqul Islam ◽  
Md Rezaul Karim Khan ◽  
Hasan Zahidur Rahman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Trace Element ◽  
Serum Magnesium ◽  
Magnesium Concentration ◽  
Control Group ◽  
Serum Magnesium Concentration ◽  
Control Serum ◽  
Study Population

Background: Alzheimer’s disease is a neurodegenerative disease. It is the most common cause of dementia in individuals older than 60 years of age. Age is the most important risk factor for Alzheimer’s disease. It is important to identify modifiable risk factors. One such important modifiable risk factor is Magnesium, a trace element. The objective of the study was to see the association of serum Magnesium concentration with Alzheimer’s disease patients. Method: It was a case control study carried out in neurology department of BSMMU, Dhaka. Total 68 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 34 were grouped as case and rest 34 were control. Serum Magnesium concentration was detected. Result: Serum Magnesium concentration was significantly lower in AD patients than that of control group [2.04±0.19 mg/dl vs 2.36±0.21 mg/dl. Conclusion: The results of our study revealed an expression that the trace element, Magnesium concentration has an association with Alzheimer’s disease. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 70-75

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