Association between Sleep Disordered Breathing and Nighttime Driving Performance in Mild Cognitive Impairment

AbstractObjectives:The effect of sleep disordered breathing (SDB) on driving performance in older adults has not been extensively investigated, especially in those with mild cognitive impairment (MCI). The aim of this study was to examine the relationship between severity measures of SDB and a simulated driving task in older adults with and without MCI.Methods:Nineteen older adults (age ≥50) meeting criteria for MCI and 23 age-matched cognitively intact controls underwent neuropsychological assessment and a driving simulator task in the evening before a diagnostic sleep study.Results:There were no differences in driving simulator performance or SDB severity between the two groups. In patients with MCI, a higher oxygen desaturation index (ODI) was associated with an increased number of crashes on the simulator task, as well as other driving parameters such as steering and speed deviation. Poorer driving performance was also associated with poorer executive functioning (set-shifting) but the relationship between ODI and crashes was independent of executive ability.Conclusions:While driving ability did not differ between older adults with and without MCI, oxygen saturation dips in MCI were related to worse driving performance. These results suggest that decreased brain integrity may render those with SDB particularly vulnerable to driving accidents. In older adults, both cognition and SDB need to be considered concurrently in relation to driving ability. (JINS, 2017,23, 502–510)

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Association between Sleep-Disordered Breathing and Neuropsychological Performance in Older Adults with Mild Cognitive Impairment

Journal of Alzheimer s Disease ◽

10.3233/jad-141860 ◽

2015 ◽

Vol 46 (1) ◽

pp. 157-165 ◽

Cited By ~ 16

Author(s):

Zoe Terpening ◽

Simon J.G. Lewis ◽

Brendon J. Yee ◽

Ron R. Grunstein ◽

Ian B. Hickie ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Sleep Disordered Breathing ◽

Neuropsychological Performance ◽

Disordered Breathing

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Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women

Obstetrical & Gynecological Survey ◽

10.1097/ogx.0b013e3182439f33 ◽

2012 ◽

Vol 67 (1) ◽

pp. 34-36 ◽

Cited By ~ 1

Author(s):

Kristine Yaffe ◽

Alison M. Laffan ◽

Stephanie Litwack Harrison ◽

Susan Redline ◽

Adam P. Spira ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Older Women ◽

Sleep Disordered Breathing ◽

Disordered Breathing

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[P2-285]: SELF-EVALUATION OF DRIVING ABILITY THROUGH A DRIVING SIMULATOR EXPERIMENT: DIFFERENCES BETWEEN PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI) AND HEALTHY ELDERLY DRIVERS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.06.938 ◽

2017 ◽

Vol 13 (7S_Part_15) ◽

pp. P724-P724 ◽

Cited By ~ 1

Author(s):

Stella Fragkiadaki ◽

Dionysia Kontaxopoulou ◽

Ion N. Beratis ◽

Dimosthenis Pavlou ◽

Nikolaos Andronas ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Driving Simulator ◽

Driving Ability ◽

Self Evaluation ◽

Elderly Drivers ◽

Healthy Elderly

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Mind Over Matter: Understanding the Relationship Between Memory Self‐Efficacy, Cognition and Brain Health in Older Adults with Probable Mild Cognitive Impairment

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.782.7 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Rebecca Horst ◽

Lindsay S. Nagamatsu

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Self Efficacy ◽

Brain Health ◽

The Relationship

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Cognitive Frailty and Its Long-Term Effect on Depression in an Older Population in Korea

Innovation in Aging ◽

10.1093/geroni/igab046.1708 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 442-442

Author(s):

Yoonjung Ji ◽

TaeWha Lee ◽

Eunkyung Kim

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Group Analysis ◽

Secondary Analysis ◽

Epidemiological Studies ◽

Physical Frailty ◽

Older Population ◽

Cognitive Frailty ◽

The Relationship

Abstract Cognitive frailty is a condition where physical frailty and mild cognitive impairment (MCI) co-exist without dementia. It occurs in 1.8%-8.9% of the general older population, and older people with depression have a higher risk of frailty. However, the relationship between cognitive frailty and depression is still unclear. This study aimed to determine the relationship between cognitive frailty and depression of older adults by time using comparative group analysis. A secondary analysis was conducted using the Korean Longitudinal Study of Aging (KLoSA) dataset from 2010 to 2018. A sample was 981 older adults who were 65 years old and without dementia over residing in the community. Cognitive frailty was defined as having a mini-mental state examination score of 18-23 and 3 or more of the Fried frailty indexes. Generalized Estimating Equation model and chi-square test were employed. Of the 981 subjects, the cognitive frailty(CF) was 28.5%, followed by robust (37.7%), physical frailty (PF, 29.4%), mild cognitive impairment (MCI, 4.4%) at baseline. The group differences on depression measured by the Center for Epidemiological Studies Depression (CESD) were statistically significant in the PF (F=4.70, p<.001) and the CF (F=4.95, p<.001) group compared to the robust group. The time difference effect (F=.09, p=.05) and a group-by-time interaction effect were observed (p<.001). This study confirmed that cognitive frailty is strongly associated with depression. Effective approaches to managing psychological wellbeing, including dementia, are essential for older adults with cognitive frailty.

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Abstract TP208: Medullary Infarction is Associated with Severe Sleep Disordered Breathing

Stroke ◽

10.1161/str.44.suppl_1.atp208 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Shuichi Fujii ◽

Kensaku Shibazaki ◽

Kenichiro Sakai ◽

Junya Aoki ◽

Junichi Uemura ◽

...

Keyword(s):

Ischemic Stroke ◽

Multivariate Regression ◽

Sleep Disordered Breathing ◽

Multivariate Regression Analysis ◽

Stroke Patients ◽

Sleep Study ◽

Respiratory Disturbance ◽

The Relationship ◽

Medullary Infarction ◽

Disordered Breathing

Background and Purpose: A relationship between presence or severity of sleep disordered breathing (SDB) and site of lesion in ischemic stroke patients has been unclear. Our aim of the present study was to investigate the relationship between presence or severity of SDB and site of ischemic lesions in stroke patients. Subjects and Methods: Between April 2010 and March 2012, consecutive ischemic stroke patients within 24 hours of onset were prospectively enrolled. Ischemic lesions were identified by MRI on admission. Patient underwent sleep study to evaluate the presence and severity of SDB within 7 days after admission. SDB was defined as a respiratory disturbance index (RDI; apnea/hypopnea events per hour) ≥ 5, and severe SDB was defined as a RDI ≥ 40. We investigated the relationship between presence or severity of SDB and clinical characteristics including site of ischemic lesions. Results: A total of 214 patients (mean age 71.3, male 132) were enrolled. Supratentrial lesion was observed in 166 (77.6%) patients and right side lesion in 101 (47.2%) patients. Sites of ischemic lesions were as follows; cortex (n=11), subcortex (n=35), cortex plus subcortex (n=75), basal ganglia (n=57), thalamus (n=13), midbrain (n=3), pons (n=27), medulla (n=11), and cerebellum (n=22). Sleep study was performed at 4 days (median). The median RDI (IQR) was 20 (10-34). SDB patients were found in 187 (87%) patients. There were no significant differences in frequency of each site of lesions between SDB and non-SDB patients. Severe SDB was observed in 42 (19.6%) patients. Age (75 (70-83) vs. 72 (64-78), p=0.047), NIHSS score on admission (3 (1-10) vs. 7 (2-12), p=0.047), the frequency of atrial fibrillation (41% vs. 22%, p=0.012) and medullary lesions (12% vs. 4%, p=0.027) were significantly higher in severe SDB patients than non-severe SDB. Multivariate regression analysis demonstrated that medullary lesions (OR 5.5, 95%CI 1.41-21.8, p=0.014) was independently associated with severe SDB. Conclusions: Medullary lesion in stroke patients should be associated with severe SDB.

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Perceived loneliness among older adults with mild cognitive impairment

International Psychogeriatrics ◽

10.1017/s1041610216000430 ◽

2016 ◽

Vol 28 (10) ◽

pp. 1681-1685 ◽

Cited By ~ 4

Author(s):

Junhong Yu ◽

Charlene L. M. Lam ◽

Tatia M. C. Lee

Keyword(s):

Older Adults ◽

Hong Kong ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Impairments ◽

Community Sample ◽

Objective Measures ◽

Subjective Measures ◽

High Prevalence ◽

The Relationship

ABSTRACTBackground:The high prevalence of mild cognitive impairment (MCI) in Hong Kong, as previously reported, requires verification. Furthermore, the relationship between loneliness, depression, and cognitive impairment with regards to MCI are unclear. The present study aims to establish the prevalence of MCI in a community sample in Hong Kong and determine if participants with MCI feel significantly lonelier, even after depression has been taken into consideration.Methods:Participants from a community sample (N = 376) were assessed with subjective and objective measures of cognitive impairments to determine whether the criteria had been met for MCI. The MCI cases are then compared with age, sex, and education-matched controls on subjective measures of loneliness and depression.Results:A total of 66 (17.6%) participants were diagnosed with MCI. These participants reported significantly higher levels of perceived loneliness and depression compared to the matched controls. Differences between groups in loneliness remained significant, even after depression levels have been controlled.Conclusions:Loneliness is implicated in MCI. The relationship between loneliness and MCI is, at least, partially independent of depression. The implications of these finding are discussed.

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