Face and Object Perception in Body Dysmorphic Disorder versus Obsessive-Compulsive Disorder: The Mooney Faces Task

AbstractObjectives: Body dysmorphic disorder (BDD) is characterized by repetitive behaviors and/or mental acts occurring in response to preoccupations with perceived defects or flaws in physical appearance. There are some similarities, but also important differences, between BDD and obsessive-compulsive disorder (OCD), not just in terms of core clinical symptoms, but possibly in the domain of perception. This study compared the nature and extent of perceptual anomalies in BDD versus OCD and health controls (HC), using a modified Mooney task. Methods: We included 21 BDD, 19 OCD, and 21 HC participants, who were age-, sex-, and IQ-matched. A set of 40 Mooney faces and 40 Mooney objects arranged in three configurations (i.e., upright, inverted, or scrambled) were presented under brief (i.e., 500 ms) free-viewing conditions. Participants were asked to decide whether each image represented a human face, an object, or neither in a forced-choice paradigm. Results: The BDD group showed significantly reduced face and object inversion effects relative to the other two groups. This was accounted for by BDD participants being significantly more accurate in identifying inverted Mooney faces and objects than the other participants. Conclusions: These data were interpreted as reflecting an overreliance on independent components at the expense of holistic (configural) processing in BDD. (JINS, 2017, 23, 471–480)

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Obsessive–Compulsive Disorder

Journal of Pharmacy Practice ◽

10.1177/0897190014521996 ◽

2014 ◽

Vol 27 (2) ◽

pp. 116-130 ◽

Cited By ~ 23

Author(s):

Gyula Bokor ◽

Peter D. Anderson

Keyword(s):

Obsessive Compulsive Disorder ◽

Selective Serotonin Reuptake Inhibitors ◽

Atypical Antipsychotics ◽

Package Insert ◽

Repetitive Behaviors ◽

Anterior Cingulate ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Mental Acts ◽

The Brain

Obsessive–compulsive disorder (OCD) is a common heterogeneous psychiatric disorder manifesting with obsessions and compulsions. Obsessions are intrusive, recurrent, and persistent unwanted thoughts. Compulsions are repetitive behaviors or mental acts that an individual feels driven to perform in response to the obsessions. The heterogeneity of OCD includes themes of obsessions, types of rituals, presence or absence of tics, etiology, genetics, and response to pharmacotherapy. Complications of OCD include interpersonal difficulties, unemployment, substance abuse, criminal justice issues, and physical injuries. Areas of the brain involved in the pathophysiology include the orbitofrontal cortex, anterior cingulate gyrus, and basal ganglia. Overall, OCD may be due to a malfunction in the cortico–striato–thalamo–cortical circuit in the brain. Neurotransmitters implicated in OCD include serotonin, dopamine, and glutamate. Numerous drugs such as atypical antipsychotics and dopaminergic agents can cause or exacerbate OCD symptoms. The etiology includes genetics and neurological insults. Treatment of OCD includes psychotherapy, pharmacotherapy, electroconvulsive therapy, transcranial magnetic simulation, and in extreme cases surgery. Exposure and response prevention is the most effective form of psychotherapy. Selective serotonin reuptake inhibitors (SSRIs) are the preferred pharmacotherapy. Higher doses than listed in the package insert and a longer trial are often needed for SSRIs than compared to other psychiatric disorders. Alternatives to SSRIs include clomipramine and serotonin/norepinephrine reuptake inhibitors. Treatment of resistant cases includes augmentation with atypical antipsychotics, pindolol, buspirone, and glutamate-blocking agents.

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Executive functioning in Body Dysmorphic Disorder and Obsessive-Compulsive Disorder

CNS Spectrums ◽

10.1017/s1092852921000705 ◽

2021 ◽

pp. 1-18

Author(s):

Long Long Chen ◽

Oskar Flygare ◽

John Wallert ◽

Jesper Enander ◽

Volen Z. Ivanov ◽

...

Keyword(s):

Executive Functioning ◽

Obsessive Compulsive Disorder ◽

Body Dysmorphic Disorder ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Science ◽

10.1126/science.1234733 ◽

2013 ◽

Vol 340 (6137) ◽

pp. 1234-1239 ◽

Cited By ~ 271

Author(s):

Susanne E. Ahmari ◽

Timothy Spellman ◽

Neria L. Douglass ◽

Mazen A. Kheirbek ◽

H. Blair Simpson ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Orbitofrontal Cortex ◽

Progressive Increase ◽

Repetitive Behaviors ◽

Mouse Behavior ◽

First Line ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Chronic Fluoxetine

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Increased grooming persisted for 2 weeks after stimulation cessation. The grooming increase was temporally coupled with a progressive increase in light-evoked firing of postsynaptic VMS cells. Both increased grooming and evoked firing were reversed by chronic fluoxetine, a first-line OCD treatment. Brief but repeated episodes of abnormal circuit activity may thus set the stage for the development of persistent psychopathology.

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Examining neurocognition in body dysmorphic disorder using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): A comparison with obsessive-compulsive disorder

Psychiatry Research ◽

10.1016/j.psychres.2015.05.094 ◽

2015 ◽

Vol 228 (3) ◽

pp. 318-324 ◽

Cited By ~ 7

Author(s):

Wei Lin Toh ◽

David J. Castle ◽

Susan L. Rossell

Keyword(s):

Obsessive Compulsive Disorder ◽

Body Dysmorphic Disorder ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Neuropsychological Status ◽

Repeatable Battery

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Executive functioning in Body Dysmorphic Disorder and Obsessive-Compulsive Disorder

10.1101/2021.04.29.21256321 ◽

2021 ◽

Author(s):

Long Long Chen ◽

Oskar Flygare ◽

John Wallert ◽

Jesper Enander ◽

Volen Ivanov ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Test Performance ◽

Symptom Severity ◽

Body Dysmorphic Disorder ◽

Spatial Working Memory ◽

Clinical Severity ◽

Stop Signal Task ◽

Healthy Controls ◽

Obsessive Compulsive ◽

Compulsive Disorder

Objective: To assess executive functions in patients with Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD) compared with healthy controls. Methods: Adults diagnosed with BDD (n=26) or OCD (n=29) according to DSM-5, and healthy controls (n=28) underwent validated and computerized neuropsychological tests; spatial working memory (SWM), Intra- extra dimensional set shifting (IED) and Stop signal task (SST), from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Test performance was compared between groups, and correlated to standardized symptom severity of BDD and OCD. Significance level was set to p<0.05. Results: There were no statistically significant between-group differences on key outcome measures in SWM, IED, or SST. There was a weak positive correlation between symptom severity and test errors on SWM and IED in both OCD and BDD groups; increased clinical severity were associated with more errors in these tests. Further, there was a negative correlation between symptom severity and SST in the BDD group. Conclusions: Patients with BDD or OCD did not differ from healthy control subjects in terms of test performance, however there were several statistically significant correlations between symptom severity and performance in those with BDD or OCD. More studies on EF in BDD and OCD are required to elucidate if there are differences in EF between these two disorders.

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The prevalence of autism spectrum traits and autism spectrum disorders in children and adolescents with obsessive compulsive disorder: a systematic review

BJPsych Open ◽

10.1192/bjo.2021.194 ◽

2021 ◽

Vol 7 (S1) ◽

pp. S56-S56

Author(s):

Claire Tiley ◽

Marinos Kyriakopoulos

Keyword(s):

Systematic Review ◽

Children And Adolescents ◽

Obsessive Compulsive Disorder ◽

Functional Impairment ◽

Body Dysmorphic Disorder ◽

Autism Spectrum ◽

Control Group ◽

Obsessive Compulsive ◽

Global Functioning ◽

Compulsive Disorder

AimsAutism Spectrum Disorder (ASD) and Obsessive Compulsive Disorder (OCD) commonly co-occur in children and adolescents (C&A); evidence suggests functional impairment is increased in those diagnosed with both disorders. The aims of this systematic review were: 1) To review studies that report on the prevalence of ASD traits and/or diagnosis in C&A with OCD. 2) To review whether the severity of OCD symptoms is related to the severity of ASD traits in C&A with OCD. 3)To review whether the severity of comorbid ASD traits or diagnosis in C&A with OCD impact on their global functioning.MethodThis systematic review was registered in PROSPERO. Prisma guidelines were followed . Electronic searches were carried out on Pubmed, EMBASE and Psychinfo with the use of selected keywords. Inclusion criteria : 1) Participants up to the age of 18 who had an ICD or DSM diagnosis of OCD. 2) Journal articles published in the English, with no date specifications. 3) Papers evaluating ASD diagnosis or traits, or where data on this could be extracted. Exclusion criteria: 1) Papers looking at OCD related disorders such as body dysmorphic disorder, compulsive skin picking, trichotillomania and hoarding disorder. 2) Samples including adults where C&A data could not be extracted. 3) Posters, abstracts and dissertations.ResultA total of 15 studies were included in the systematic review. Seven of these studies directly compared the prevalence of ASD traits (measured by questionnaires) or diagnosis in OCD to a control group or normative data, with all studies reporting a significant elevation in ASD trait scores and diagnosis in OCD. Ten of the studies reported on the correlation between ASD trait severity and OCD severity. Four studies identified a significant correlation between ASD and OCD total scores or specified subscales. In contrast, one study found significantly elevated OCD scores in an OCD only group when compared to a comorbid OCD and ASD group. Three studies reported on the correlation between ASD scores and functional impairment or compared an OCD only group to a comorbid group. All three studies demonstrated that the presence ASD or ASD traits are associated with elevated scores in global functional impairment.ConclusionIn conclusion, this review suggests that there is an increased prevalence of ASD traits and diagnosis amongst C&A with OCD. Elevated ASD traits within this population are associated with a greater impact on global functioning.

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