A Meta-Analysis of Neuropsychological Functioning in the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants

2019 ◽  
Vol 26 (3) ◽  
pp. 322-330 ◽  
Author(s):  
Vidyulata Kamath ◽  
Emily R. Sutherland ◽  
Grace-Anna Chaney
Keyword(s):  
Neuropsychological Functioning ◽  
Meta Analysis ◽  
Primary Progressive Aphasia ◽  
Task Characteristics ◽  
Visuospatial Memory ◽  
Set Shifting ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Neuropsychological Profile ◽  
Visual Set

AbstractObjectives:The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA.Methods:We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges’ g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA.Results:In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests.Conclusions:Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.

scholarly journals Meta-Analysis on the Effects of Transcranial Direct Current Stimulation on Naming of Elderly with Primary Progressive Aphasia

2020 ◽  
Vol 17 (3) ◽  
pp. 1095 ◽  
Author(s):  
Haewon Byeon
Keyword(s):  
Direct Current ◽  
Effect Size ◽  
Transcranial Direct Current Stimulation ◽  
Meta Analysis ◽  
Primary Progressive Aphasia ◽  
Cochrane Library ◽  
Progressive Aphasia ◽  
Direct Current Stimulation ◽  
Primary Progressive ◽  
Standard Mean Difference

Purpose: This study aimed to conduct a qualitative evaluation by synthesizing previous studies on the effect of transcranial direct current stimulation (tDCS) on primary progressive aphasia (PPA)’s naming ability and prove the effects of tDCS mediation on PPA naming using meta-analysis. Methods: This study searched literature published from January 2000 to July 2019 using four academic databases (i.e., PubMed, Web of Science, MEDLINE, and Cochrane Library). The final seven publications were systematically evaluated and meta-analysis was conducted for two papers. The effect size was estimated by a standard mean difference (SMD) using Hedge’s g, and the significance of effect size was confirmed using the 95% confidence interval. Results: The results of seven previous studies’ quality assessments ranged from 15 to 26, which were rated above adequate. The results of the meta-analysis showed that the effect size was 0.82 (95% CI: 0.16–1.47), which was a significant ‘large effect’. Conclusions: This meta-analysis proved that tDCS intervention significantly improved the naming performance of PPA. Future studies must confirm the effects of tDCS on naming intervention by using meta-analysis including many RCT studies.

scholarly journals Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis

2018 ◽  
Vol 92 ◽  
pp. 243-254 ◽  
Author(s):  
Willem S. Eikelboom ◽  
Nikki Janssen ◽  
Lize C. Jiskoot ◽  
Esther van den Berg ◽  
Ardi Roelofs ◽  
...  
Keyword(s):  
Working Memory ◽  
Meta Analysis ◽  
Memory Function ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

A-175 Logopenic Variant of Primary Progressive Aphasia in a 66-Year Old Female—A Case Study

2020 ◽  
Vol 35 (6) ◽  
pp. 969-969
Author(s):  
Kurniadi N ◽  
Davis J
Keyword(s):  
Medical History ◽  
Test Data ◽  
Processing Speed ◽  
Verbal Learning ◽  
Primary Progressive Aphasia ◽  
Semantic Knowledge ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Neuropsychological Profile

Abstract Objective The semantic, logopenic, and nonfluent/aggramatic variants of primary progressive aphasia (PPA) have distinct clinical profiles. However, much overlap exists and many questions remain regarding the nature of language impairments in each variant. This case study seeks to contribute to our understanding of the neuropsychological profile, syntactic, and phonological processes involved in logopenic variant PPA (lvPPA). Method The current case study was of a 66-year old female who gradually developed symptoms consistent with lvPPA during the prior four-year period, with marked worsening in the last few months. A collateral informant indicated that she was independent for basic and advanced activities of daily living. Brain/head imaging had not been conducted; medical history was unremarkable. Results Speech was notable for frequent pauses due to word-finding difficulty, circumlocution, and impaired naming, repetition, and verbal abstraction; fluency and comprehension were intact. Test data revealed significant impairments in tasks mediated by language including verbal processing speed, semantic knowledge, phonemic and semantic fluency, verbal learning and memory, verbal set-shifting, and judgment. Comprehension, non-verbal attention and processing speed, recognition for visual information, and performance on tasks of non-verbal executive functioning were intact. Depression and anxiety were denied. Conclusions Findings were notable for prominent language deficits, with preserved articulation, basic comprehension, and no evidence of visual agnosia. Her progression of symptoms, medical history, and test data were not consistent with a typical Alzheimer’s or vascular process, but were most consistent with lvPPA. Neurology consultation, MRI brain with volumetric analysis, and speech therapy were recommended.

Motor Speech Phenotypes of Frontotemporal Dementia, Primary Progressive Aphasia, and Progressive Apraxia of Speech

2017 ◽  
Vol 60 (4) ◽  
pp. 897-911 ◽  
Author(s):  
Matthew L. Poole ◽  
Amy Brodtmann ◽  
David Darby ◽  
Adam P. Vogel
Keyword(s):  
Frontotemporal Dementia ◽  
Meta Analysis ◽  
Primary Progressive Aphasia ◽  
Control Group ◽  
Apraxia Of Speech ◽  
Speech Impairment ◽  
Motor Speech ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Neuroimaging Data

Purpose Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressive aphasia (PPA), and progressive apraxia of speech in order to identify the most effective measures for diagnosis and monitoring, and to elucidate associations between speech and neuroimaging. Method Speech and neuroimaging data described in studies of FTD and PPA were systematically reviewed. A meta-analysis was conducted for speech measures that were used consistently in multiple studies. Results The methods and nomenclature used to describe speech in these disorders varied between studies. Our meta-analysis identified 3 speech measures which differentiate variants or healthy control-group participants (e.g., nonfluent and logopenic variants of PPA from all other groups, behavioral-variant FTD from a control group). Deficits within the frontal-lobe speech networks are linked to motor speech profiles of the nonfluent variant of PPA and progressive apraxia of speech. Motor speech impairment is rarely reported in semantic and logopenic variants of PPA. Limited data are available on motor speech impairment in the behavioral variant of FTD. Conclusions Our review identified several measures of speech which may assist with diagnosis and classification, and consolidated the brain–behavior associations relating to speech in FTD, PPA, and progressive apraxia of speech.

scholarly journals Efficacy of Noninvasive Brain Stimulation (tDCS or TMS) Paired with Language Therapy in the Treatment of Primary Progressive Aphasia: An Exploratory Meta-Analysis

2020 ◽  
Vol 10 (9) ◽  
pp. 597
Author(s):  
Nicole R. Nissim ◽  
Paul J. Moberg ◽  
Roy H. Hamilton
Keyword(s):  
Brain Stimulation ◽  
Meta Analysis ◽  
Random Effect ◽  
Primary Progressive Aphasia ◽  
Language Outcomes ◽  
Language Therapy ◽  
Language Abilities ◽  
Noninvasive Brain Stimulation ◽  
Progressive Aphasia ◽  
Primary Progressive

Noninvasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), paired with behavioral language therapy, have demonstrated the capacity to enhance language abilities in primary progressive aphasia (PPA), a debilitating degenerative neurological syndrome that leads to declines in communication abilities. The aim of this meta-analysis is to systematically evaluate the efficacy of tDCS and TMS in improving language outcomes in PPA, explore the magnitude of effects between stimulation modalities, and examine potential moderators that may influence treatment effects. Standard mean differences for change in performance from baseline to post-stimulation on language-related tasks were evaluated. Six tDCS studies and two repetitive TMS studies met inclusion criteria and provided 22 effects in the analysis. Random effect models revealed a significant, heterogeneous, and moderate effect size for tDCS and TMS in the enhancement of language outcomes. Findings demonstrate that naming ability significantly improves due to brain stimulation, an effect found to be largely driven by tDCS. Future randomized controlled trials are needed to determine long-term effectiveness of noninvasive brain stimulation techniques on language abilities, further delineate the efficacy of tDCS and TMS, and identify optimal parameters to enable the greatest gains for persons with PPA.

Initial Neuropsychological Profile of a Series of 20 Patients with Logopenic Variant of Primary Progressive Aphasia

2013 ◽  
Vol 36 (4) ◽  
pp. 799-808 ◽  
Author(s):  
Eloi Magnin ◽  
Gilles Chopard ◽  
Sabrina Ferreira ◽  
Geraldine Sylvestre ◽  
Elfried Dariel ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Neuropsychological Profile
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