scholarly journals Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal

2013 ◽  
Vol 17 (01) ◽  
pp. 33-40 ◽  
Author(s):  
Lisia von Diemen ◽  
Flavio Kapczinski ◽  
Anne Orgle Sordi ◽  
Joana Correa de Magalhães Narvaez ◽  
Luciano Santos Pinto Guimarães ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Crack Cocaine ◽  
Brain Derived Neurotrophic Factor ◽  
Cocaine Withdrawal ◽  
Factor Expression

scholarly journals Stress and Inflammation Reduce Brain-Derived Neurotrophic Factor Expression in First-Episode Psychosis

2011 ◽  
Vol 72 (12) ◽  
pp. 1677-1684 ◽  
Author(s):  
Valeria Mondelli ◽  
Annamaria Cattaneo ◽  
Martino Belvederi Murri ◽  
Marta Di Forti ◽  
Rowena Handley ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Factor Expression

scholarly journals Elaphuri Davidiani Cornu Improves Depressive-Like Behavior in Mice and Increases Neurotrophic Factor Expression in Mouse Primary Astrocytes via cAMP and ERK-Dependent Pathways

2020 ◽  
Vol 11 ◽  
Author(s):  
Yue Zhu ◽  
Mengqiu Liu ◽  
Suchen Qu ◽  
Cheng Cao ◽  
Chongqi Wei ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Antidepressant Effect ◽  
Aqueous Extracts ◽  
Nerve Growth ◽  
Primary Astrocyte ◽  
Factor Expression

Elaphuri Davidiani Cornu (EDC) is the natural shedding horn of Elaphurus davidiauus Millne-Edwards that was used by people in ancient China for maintaining physical and mental health. We evaluated the antidepressant effect of EDC using depression-like animal models and explored possible mechanisms in mouse primary astrocyte cultures. We found that aqueous extracts of EDC significantly improved depression-like behavior in a mouse model of depression. The extracts enhanced expression of nerve growth factor and brain-derived neurotrophic factor neurotrophic factors in mouse prefrontal cortex and hippocampus tissues. In the mouse primary astrocyte cultures, the EDC aqueous extracts significantly increased the neurotrophic factor expression both at the transcriptional and protein levels. EDC extracts might exhibit these functions by regulating matrix metalloprotein-9 of the nerve growth factor and brain-derived neurotrophic factor metabolic pathways and might enhance expression of neurotrophic factors via the cAMP- and ERK-dependent pathways. We confirmed this possibility by showing the effects of related inhibitors, providing scientific evidence that supports the utility of EDC in the development of drugs to treat major depressive disorders.

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