scholarly journals Early life adversity increases the salience of later life stress: an investigation of interactive effects in the PSID

2019 ◽  
Vol 11 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Katherine Saxton ◽  
Laura Chyu
Keyword(s):  
Psychological Distress ◽  
Early Life ◽  
Chronic Conditions ◽  
Risk Model ◽  
Panel Study ◽  
Large Body ◽  
Poor Health ◽  
Interactive Effects ◽  
Early Life Adversity ◽  
Fair Poor

AbstractA large body of evidence has shown that stress throughout life is associated with health trajectories, but the combination of adverse experiences at different stages of the life course is not yet well understood. This study examines the interactions between childhood adversity, adulthood adversity, and adult physical and mental health. Using data from The Childhood Retrospective Circumstances Study (CRCS) supplement to the Panel Study of Income Dynamics (PSID), we created indices of early life adversity (EAI) and adult adversity (AAI). We used logistic regression to examine the effects of EAI and AAI, adjusting for age, sex, race/ethnicity, health behaviors, and childhood health as covariates in all models. We repeated this analysis for the outcomes of fair/poor health, two or more chronic conditions, and psychological distress in adulthood. For all the three outcomes, our findings suggest increasing salience of adult adversity among those who experienced higher levels of early adversity. Individuals with high EAI and high AAI exhibited the highest odds of fair/poor health (OR = 5.71), chronic conditions (OR = 3.06), and psychological distress (OR = 13.08) compared to those with low EAI and low AAI. These findings are consistent with the accumulation of risk or dual risk model of stress and health. Adversity in childhood amplifies the health risks associated with stress in adulthood for multiple health outcomes.

Explaining public support for violence against politicians during conflict: Evidence from a panel study in Israel

2020 ◽  
pp. 002234332090535
Author(s):  
Julia Elad-Strenger ◽  
Brian J Hall ◽  
Stevan E Hobfoll ◽  
Daphna Canetti
Keyword(s):  
Psychological Distress ◽  
Political Violence ◽  
Panel Study ◽  
Public Support ◽  
Political Stability ◽  
Political Orientation ◽  
Interactive Effects ◽  
Perceived Threat ◽  
Political Actors ◽  
Protective Strategy

What drives citizens’ support for violence against domestic political actors? Despite its potentially devastating consequences, there is surprisingly little research on the antecedents of this unique form of political violence. Building upon recent insights on the psychological implications of exposure to conflict on support for political violence, we examined the motivations underlying public support for violence against politicians in the context of protracted conflict. Using a two-wave panel design among Jewish-Israelis, we examined the interactive effects of conflict-induced perceived threat, psychological distress, and political orientation on support for violence against politicians. Consistent with previous findings on the psychological implications of conflict, our findings suggest that conflict-induced threat perceptions play an important role in predicting support for violence against politicians. Nevertheless, our findings point to important boundary conditions to these effects: the strength of the relationship between perceived threat and attitudes towards political violence is qualified by the level of chronic conflict-related psychological distress, and the direction of the effects of perceived threat is qualified by individuals’ self-placement on the left-right continuum. More specifically, we found that perceived threat increased rightists’ support and decreases leftists’ support for violence against politicians, only under high, but not low, conflict-related psychological distress. The main conclusion of this study is that support for violence against politicians can be seen as an ideology-driven protective strategy against the negative psychological implications of exposure to violent conflict. By pointing to the importance of understanding the interactive role of psychological and political factors in determining public support for such acts, our findings therefore contribute to the understanding of a relatively understudied phenomenon with potentially catastrophic effects on political stability.

Self-Reported Health Status and Medical Debt

2018 ◽  
Vol 29 (1) ◽  
pp. 36-44
Author(s):  
Patrick Richard ◽  
Nilam Patel ◽  
Yuan-Chiao Lu ◽  
Pierre Alexandre
Keyword(s):  
Health Status ◽  
Financial Burden ◽  
Panel Study ◽  
Poor Health ◽  
Poor Health Status ◽  
Medical Debt ◽  
Reported Health ◽  
Using Data ◽  
Self Reported Health Status ◽  
Fair Poor

This paper examines the relationship between self-reported health status and medical debt outcomes using data from the 2013 Panel Study of Income Dynamics. There were two outcomes of interest: (a) the likelihood of having any medical debt, which included 4,227 households and (b) the amount of medical debt (medical debt > 0), which included 631 households. The results from the multivariate models showed that fair/poor health status increased the likelihood of having any medical debt by 73% and was associated with an increase in the amount of medical debt among those with medical debt by about 77% (p < .001) compared to those who reported better health. Poor health status appears to impose a financial burden on some households.

scholarly journals Early maternal separation accelerates the progression of endometriosis in adult mice

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Qiqi Long ◽  
Xishi Liu ◽  
Sun-Wei Guo
Keyword(s):  
Signaling Pathway ◽  
Early Life ◽  
Maternal Separation ◽  
Large Body ◽  
Late Pregnancy ◽  
Camp Response Element Binding ◽  
Early Life Adversity ◽  
Adult Mice ◽  
Element Binding Protein ◽  
Generalized Hyperalgesia

Abstract Background A large body of research highlights the importance of early-life environmental impact on the health outcome in adulthood. However, whether early-life adversity (ELA) has any impact on the development of endometriosis is completely unclear. In this study, we tested the hypothesis that ELA, as manifested by neonatal separation, can accelerate the progression of endometriosis in mouse through activation of the adrenergic receptor β2 (ADRB2) signaling pathway, leading to increased angiogenesis and progression of endometriotic lesions. Methods Eight female Balb/C mice, in late pregnancy, were used used for this study, which later gave birth to 22 female newborn pubs. Eleven additional female Balb/C mice were also used as donors of uterine tissues. The 22 newborn pubs were randomly divided into 2 equal-sized groups, maternal separation (MS) and no separation (NS). Pubs in the MS group were separated from their dams for 3 h/day from postnatal day (PND) 1 to 21, while those in the NS control remained in the home cage with their dams. In adulthood (8-week old), 3 mice in each group were randomly selected to undergo a battery of behavior tests. The remaining 8 mice in each group were induced with endometriosis by intraperitoneal injection of uterine fragments from donor mice. Four weeks after the induction, all mice were sacrificed and their endometriotic lesions were excised for quantification and then prepared for immunohistochemistry analysis. Results We confirmed that MS during infancy resulted in anxiety and depression-like behaviors as previously reported. We also found that in MS mice the lesion weight was increased by over 2 folds and generalized hyperalgesia was also significantly increased as compared with NS mice. Immunostaining analysis demonstrated that MS accelerated the development of endometriosis likely through decreased dopamine receptor D2 (DRD2) expression and activation of the ADRB2/cAMP-response element binding protein (CREB) signaling pathway, leading to increased angiogenesis and progression of endometriotic lesions. Conclusions Exposure of female mouse pups to ELA such as MS during their infancy period accelerates the progression of endometriosis, possibly through altered neuronal wiring and hyperactivity of the hypothalamic-pituitary-adrenal axis.

scholarly journals Externalizing Behaviors Buffer the Effects of Early Life Adversity on Physiologic Dysregulation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Stacey N. Doan ◽  
Nadya Dich ◽  
Thomas E. Fuller-Rowell ◽  
Gary W. Evans
Keyword(s):  
Early Life ◽  
Allostatic Load ◽  
Externalizing Behaviors ◽  
Risk Index ◽  
Cumulative Risk ◽  
Biological Marker ◽  
Interactive Effects ◽  
Early Life Adversity ◽  
Physiological Dysregulation ◽  
Models Of Development

Abstract The present study examined the counterintuitive hypothesis that externalizing behaviors such as aggression, although in many respects detrimental, may be functional and protect against the detrimental health consequences of early life adversity. In particular, in line with evolutionary models of development, we argue that externalizing problems moderate the association between chronic stress exposure and allostatic load, a biological marker of chronic physiological dysregulation. Prospective interactive effects of externalizing behaviors and cumulative risk (a confluence of multiple risk factors) on children’s allostatic load were assessed in 260 children (46% female, baseline age = 9). Exposure to early life adversity was assessed at baseline using a cumulative risk index. Externalizing behaviors were reported by parents at baseline. Allostatic load was measured at baseline and at ages 13 and 17, using endocrine, cardiovascular and metabolic parameters. Results of linear-mixed effects models indicated that the association between cumulative risk and allostatic load was attenuated for adolescents who scored high on externalizing behaviors. Further examination of sex differences indicated that the findings were more pronounced among males than females.

Resilience in Adolescence: Prospective Self Moderates the Association of Early Life Adversity with Psychopathology

2019 ◽  
Author(s):  
Mary Elizabeth Zinn ◽  
Edward Huntley ◽  
Daniel Keating
Keyword(s):  
Behavior Problems ◽  
Identity Formation ◽  
Externalizing Behavior ◽  
Early Life ◽  
The United States ◽  
Externalizing Behavior Problems ◽  
Developmental Period ◽  
Equation Modeling ◽  
Early Life Adversity ◽  
Latent Construct

Introduction. Early life adversity (ELA) can result in negative health-outcomes, including psychopathology. Evidence suggests that adolescence is a critical developmental period for processing ELA. Identity formation, which is crucial to this developmental period, may moderate the effect between ELA and psychopathology. One potential moderating variable associated with identity formation is Prospective Self, a latent construct comprised of future-oriented attitudes and behaviors.Methods. Participants are from the first wave of an ongoing longitudinal study designed to characterize behavioral and cognitive correlates of risk behavior trajectories. A community sample of 10th and 12th grade adolescents (N = 2017, 55% female) were recruited from nine public school districts across eight Southeastern Michigan counties in the United States. Data were collected in schools during school hours or after school via self-report, computer-administered surveys. Structural equation modeling was used in the present study to assess Prospective Self as a latent construct and to evaluate the relationship between ELA, psychopathology, and Prospective Self.Results. Preliminary findings indicated a satisfactory fit for the construct Prospective Self. The predicted negative associations between Prospective Self and psychopathology were found and evidence of moderation was observed for externalizing behavior problems, such that the effects of ELA were lower for individuals with higher levels of Prospective Self. Conclusion. These results support the role of Prospective Self in conferring resilience against externalizing behavior problems associated with ELA among adolescents. Keywords: Adolescence, Adverse Childhood Experiences, Psychopathology, Self-concept, Adolescent Health, Early Life Adversity

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