In Vivo Electrochemical Detection of Nitric Oxide in Tumor-Bearing Mice

2007 ◽  
Vol 79 (3) ◽  
pp. 1030-1033 ◽  
Author(s):  
Sophie Griveau ◽  
Charlotte Dumézy ◽  
Johanne Séguin ◽  
Guy G. Chabot ◽  
Daniel Scherman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Electrochemical Detection ◽  
Tumor Bearing

In Vivo Electrochemical Detection of Nitroglycerin-Derived Nitric Oxide in Tumor-Bearing Mice

2009 ◽  
Vol 21 (3-5) ◽  
pp. 631-634 ◽  
Author(s):  
Sophie Griveau ◽  
Johanne Seguin ◽  
Daniel Scherman ◽  
Guy G. Chabot ◽  
Fethi Bedioui
Keyword(s):  
Nitric Oxide ◽  
Electrochemical Detection ◽  
Tumor Bearing

Induction of nitric oxide production in infiltrating leukocytes following in vivo irradiation of tumor-bearing mice

1999 ◽  
Vol 7 (2) ◽  
pp. 86-97 ◽  
Author(s):  
Yoram Vodovotz ◽  
Deborah Coffin ◽  
Anne Marie DeLuca ◽  
Leslie McKinney ◽  
John A. Cook ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Tumor Bearing ◽  
Oxide Production

scholarly journals In vitro/ In vivo Electrochemical Detection of Pt(II) Species

2021 ◽  
Author(s):  
Alexander Vaneev ◽  
Petr Gorelkin ◽  
Olga Krasnovskaya ◽  
Roman Akasov ◽  
Daniil Spector ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Single Cells ◽  
Electrochemical Technique ◽  
Breast Adenocarcinoma ◽  
Tumor Spheroids ◽  
Tumor Bearing ◽  
Advanced Tumor ◽  
Mcf 7

The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and novel techniques for simple, non-expensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the use of platinized carbon nanoelectrodes (PtNE) for electrochemical detection of platinum-based drugs in various biological models, including single cells and tumor spheroids in vitro, and inside solid tumors in vivo. We have demonstrated quantitative direct detection of Pt(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and cisplatin-based DNP prodrug. To realize the potential of this technique in advanced tumor models, we measured Pt(II) in 3D tumor spheroids in vitro and tumor-bearing mice in vivo. The concentration gradient of Pt (II) species correlated with the distance from the sample surface in MCF-7 tumor spheroids. We then performed detection of Pt(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We found that there was deeper penetration of DNP in comparison to cisplatin. This research demonstrates a novel minimally invasive, real-time electrochemical technique for the study of platinum-based drugs.

C12. Performances and applicability of electrochemical NO-sensor for in vivo detection of nitric oxide in tumor-bearing mice

Nitric Oxide ◽  
2007 ◽  
Vol 17 ◽  
pp. 22-23
Author(s):  
S. Griveau ◽  
C. Dumézy ◽  
J. Seguin ◽  
G.G. Chabot ◽  
D. Scherman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Bearing ◽  
In Vivo Detection ◽  
No Sensor

In vivo electrochemical detection of nitric oxide release in the dorsal motor nucleus of the vagus after intracisternal administration of bombesin

1998 ◽  
Vol 114 ◽  
pp. A1128
Author(s):  
B. Beltrán ◽  
A. Méndez ◽  
E. Quintero ◽  
J.L. Gonzalez-Mora ◽  
J.V. Esplugues
Keyword(s):  
Nitric Oxide ◽  
Electrochemical Detection ◽  
Motor Nucleus ◽  
Nitric Oxide Release ◽  
Dorsal Motor Nucleus

Clinical Evaluation of Radio-Labelled Bleomycin for Tumor Detection

1978 ◽  
Vol 17 (06) ◽  
pp. 238-248
Author(s):  
H. Beekhuis ◽  
M.A.P.C. van de Poll ◽  
A. Versluis ◽  
H. Jurjens ◽  
M.G. Woldring ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Acidic Solution ◽  
Tumor Detection ◽  
Neutral Solution ◽  
Normal Tissues ◽  
Patients With Cancer ◽  
Tumor Bearing

Investigations with bleomycin labelled with radionuclides other than 57Co in patients with cancer and in tumor-bearing animals are described. In patients 57Co-bleo appears to be a better tumor-seeking radiopharmaceutical than 111In-bleo, 99mTc-bleo or 197Hg-bleo. This can be explained by a higher stability in vivo and a better tumor-seeking property of 57Co-bleo and less disturbing activity in the cardiac pool and in bone and other normal tissues when assessing the scintigram.Results with 111In-bleo labelled in acidic solution are not essentially different from those with 111In-bleo labelled in neutral solution.Results of 197Hg-bleo are almost identical with those of 197HgCl2 regarding the tumor-seeking effect as well as the distribution in normal tissues and organs. Probably the complex of 197Hg to bleomycin is not stable in vivo. The superiority of 57Co-bleo over 99mTc-bleo, 197Hg-bleo and also over 67Cu-bleo is confirmed by experiments on tumor bearing animals.We may conclude that the indication for use of bleomycin as a tumor-seeking pharmaceutical labelled with 111In, 99mTc, 197Hg or 67Cu seems to be very limited.

A Comparative Study of the in vivo Distribution of 32P-Polyphosphates and 32P-Orthophosphate

1972 ◽  
Vol 11 (01) ◽  
pp. 70-78
Author(s):  
Esther Miller ◽  
Leopoldo Anghileri
Keyword(s):  
Radiation Dose ◽  
Comparative Study ◽  
Soft Tissues ◽  
Tumor Bearing ◽  
In Vivo Distribution ◽  
The Cross ◽  
Total Body

SummaryThe distribution of 32P-polyphosphates (lineal and cross-linked) and 32Porthophosphate in normal and tumor bearing animals has been studied. Differences between the cross-linked and the lineal form are related to a different degree of susceptibility to the hydrolysis by the phosphatases. In contrast to orthophosphate, the polyphosphates showed a lower accumulation in soft tissues which gives an advantageous reduction of the total body radiation dose.

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