Stable-Isotope-Assisted MALDI-TOF Mass Spectrometry for Accurate Determination of Nucleotide Compositions of PCR Products

1999 ◽  
Vol 71 (15) ◽  
pp. 3118-3125 ◽  
Author(s):  
Xian Chen ◽  
Zhengdong Fei ◽  
Lloyd M. Smith ◽  
E. Morton Bradbury ◽  
Vahid Majidi
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Accurate Determination ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof ◽  
Pcr Products

Qualitative determination of early Maillard-products by MALDI-TOF mass spectrometry peptide mapping

2002 ◽  
Vol 215 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Thomas Kislinger ◽  
Andreas Humeny ◽  
Silke Seeber ◽  
Cord-Michael Becker ◽  
Monika Pischetsrieder
Keyword(s):  
Mass Spectrometry ◽  
Peptide Mapping ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof ◽  
Maillard Products ◽  
Qualitative Determination

Determination of sensitivity of microorganisms of the Klebsiella genus to antimicrobial drugs by the MALDI-TOF MS method

Bacteriology ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 8-13
Author(s):  
A.A. Samoilova ◽  
◽  
I.V. Likhachev ◽  
E.V. Zueva ◽  
E.V. Rogacheva ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antibiotic Resistance ◽  
Mass Spectra ◽  
Antimicrobial Agents ◽  
Antimicrobial Drugs ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof ◽  
Resistance Markers ◽  
Klebsiella Spp

Actual microbiological diagnostics of infections caused by Klebsiella spp. should include isolation of the strain, its identification and fastest possible determination of the pathogen susceptibility to antimicrobial agents. We evaluated the prospects of using MALDI-TOF mass spectrometry to determine the susceptibility of Klebsiella spp. strains to antimicrobial agents. According to the results of mass spectrometry Klebsiella spp. strains analysis, we carried out cluster analysis by the UPGMA method based on mass spectra and data on the susceptibility of the studied strains to antimicrobial agents, and then studied the obtained dendrograms. We identified the areas with the highest probability of the location of antibiotic resistance markers by comparing the mass spectra of susceptible and resistant microorganisms at different concentrations of antimicrobial agents. Thus, using MALDI-TOF mass spectrometry, a new direction in assessing the susceptibility of Klebsiella spp. to antimicrobial agents can be formed. Key words: antibiotic resistance, Klebsiella spp., MALDI-TOF mass spectrometry

Large-scale determination of SNP allele frequencies in DNA pools using MALDI-TOF mass spectrometry

2002 ◽  
Vol 20 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Monika Werner ◽  
Michael Sych ◽  
Nicole Herbon ◽  
Thomas Illig ◽  
Inke R. König ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Large Scale ◽  
Allele Frequencies ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof ◽  
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