Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase

Biochemistry ◽  
2018 ◽  
Vol 57 (23) ◽  
pp. 3265-3277 ◽  
Author(s):  
Sandra Schlee ◽  
Thomas Klein ◽  
Magdalena Schumacher ◽  
Julian Nazet ◽  
Rainer Merkl ◽  
...  
Keyword(s):  
Active Site ◽  
Glycerol Phosphate ◽  
Loop Dynamics ◽  
Relationship Of ◽  
Phosphate Synthase

scholarly journals Controlling Active Site Loop Dynamics in the (β/α)8 Barrel Enzyme Indole-3-Glycerol Phosphate Synthase

Catalysts ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 129 ◽  
Author(s):  
Kathleen O’Rourke ◽  
Aneta Jelowicki ◽  
David Boehr
Keyword(s):  
Active Site ◽  
Glycerol Phosphate ◽  
Loop Dynamics ◽  
Phosphate Synthase

Locating Al in the DABCO catalyst before and after Al extraction

1990 ◽  
Vol 48 (4) ◽  
pp. 265-267
Author(s):  
Kathleen B. Reuter
Keyword(s):  
Active Site ◽  
Inverse Relationship ◽  
Transverse Direction ◽  
Reaction Rate ◽  
Acid Phosphate ◽  
Fracture Surfaces ◽  
Al Content ◽  
Before And After ◽  
Relationship Of

The reaction rate and efficiency of piperazine to 1,4-diazabicyclo-octane (DABCO) depends on the Si/Al ratio of the MFI topology catalysts. The Al was shown to be the active site, however, in the Si/Al range of 30-200 the reaction rate increases as the Si/Al ratio increases. The objective of this work was to determine the location and concentration of Al to explain this inverse relationship of Al content with reaction rate.Two silicalite catalysts in the form of 1/16 inch SiO2/Al2O3 bonded extrudates were examined: catalyst A with a Si/Al of 83; and catalyst B, the acid/phosphate Al extracted form of catalyst A, with a Si/Al of 175. Five extrudates from each catalyst were fractured in the transverse direction and particles were obtained from the fracture surfaces near the center of the extrudate diameter. Particles were also obtained from the outside surfaces of five extrudates.

scholarly journals A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis

FEBS Journal ◽  
2008 ◽  
Vol 276 (1) ◽  
pp. 144-154 ◽  
Author(s):  
Hongbo Shen ◽  
Feifei Wang ◽  
Ying Zhang ◽  
Qiang Huang ◽  
Shengfeng Xu ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Multidrug Resistant ◽  
Glycerol Phosphate ◽  
Phosphate Synthase

scholarly journals Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

FEBS Journal ◽  
2014 ◽  
Vol 281 (12) ◽  
pp. 2820-2837 ◽  
Author(s):  
Leighanne A. Brammer Basta ◽  
Hetalben Patel ◽  
Lazaros Kakalis ◽  
Frank Jordan ◽  
Caren L. Freel Meyers
Keyword(s):  
Active Site ◽  
Substrate Binding ◽  
Critical Residues ◽  
Phosphate Synthase

scholarly journals Crystal Structure of Imidazole Glycerol Phosphate Synthase

Structure ◽  
2001 ◽  
Vol 9 (10) ◽  
pp. 987-997 ◽  
Author(s):  
Barnali N Chaudhuri ◽  
Stephanie C Lange ◽  
Rebecca S Myers ◽  
Sridar V Chittur ◽  
V.Jo Davisson ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Glycerol Phosphate ◽  
Imidazole Glycerol Phosphate ◽  
Phosphate Synthase
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