scholarly journals Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates

2015 ◽  
Vol 27 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Kazuhide Sato ◽  
Alexander P. Gorka ◽  
Tadanobu Nagaya ◽  
Megan S. Michie ◽  
Roger R. Nani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Optical Imaging ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Antibody Conjugates ◽  
Imaging Properties ◽  
In Vivo Optical Imaging

scholarly journals Effect of charge localization on the in vivo optical imaging properties of near-infrared cyanine dye/monoclonal antibody conjugates

2016 ◽  
Vol 12 (10) ◽  
pp. 3046-3056 ◽  
Author(s):  
Kazuhide Sato ◽  
Alexander P. Gorka ◽  
Tadanobu Nagaya ◽  
Megan S. Michie ◽  
Yuko Nakamura ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Optical Imaging ◽  
Chemical Structure ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Charge Localization ◽  
Antibody Conjugates ◽  
Imaging Properties ◽  
In Vivo Optical Imaging

Small changes on cyanine dyes to the chemical structure can alter in vivo pharmacokinetics of mAb–dye conjugates.

scholarly journals Bright and stable near-infrared Pluronic–silica nanoparticles as contrast agents for in vivo optical imaging

2016 ◽  
Vol 4 (33) ◽  
pp. 5560-5566 ◽  
Author(s):  
Lesan Yan ◽  
Huiquan Wang ◽  
Anqi Zhang ◽  
Calvin Zhao ◽  
Yongping Chen ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Contrast Agents ◽  
Optical Imaging ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Circulation Time ◽  
In Vivo Optical Imaging

The IR780@NPs exhibited excellent characteristics for in vivo imaging with a long circulation time and high retention in tumor and sentinel lymph node.

scholarly journals Near-Infrared Fluorescent Nanoprobes for in Vivo Optical Imaging

Nanomaterials ◽  
2012 ◽  
Vol 2 (2) ◽  
pp. 92-112 ◽  
Author(s):  
Chai-Hoon Quek ◽  
Kam W. Leong
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
In Vivo Optical Imaging

scholarly journals Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging

2005 ◽  
Vol 102 (8) ◽  
pp. 2922-2927 ◽  
Author(s):  
P. P. Ghoroghchian ◽  
P. R. Frail ◽  
K. Susumu ◽  
D. Blessington ◽  
A. K. Brannan ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Soft Matter ◽  
Near Infrared ◽  
Self Assembled ◽  
In Vivo Optical Imaging

Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for the in vivo optical imaging of amyloid-β plaques

2021 ◽  
pp. 105167
Author(s):  
Yong Dae Park ◽  
Mayank Kinger ◽  
Changho Min ◽  
Sang Yeob Lee ◽  
Youngjoo Byun ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Amyloid Β ◽  
In Vivo Optical Imaging

Synthesis of chitosan-coated near-infrared layered double hydroxide nanoparticles for in vivo optical imaging

2012 ◽  
Vol 22 (12) ◽  
pp. 5503 ◽  
Author(s):  
Pei-Ru Wei ◽  
Shih-Hsun Cheng ◽  
Wei-Neng Liao ◽  
Kun-Che Kao ◽  
Ching-Feng Weng ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Layered Double Hydroxide ◽  
Near Infrared ◽  
Double Hydroxide ◽  
In Vivo Optical Imaging ◽  
Layered Double Hydroxide Nanoparticles

scholarly journals Impact of C4′-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates

2015 ◽  
Vol 12 (9) ◽  
pp. 3303-3311 ◽  
Author(s):  
Kazuhide Sato ◽  
Tadanobu Nagaya ◽  
Yuko Nakamura ◽  
Toshiko Harada ◽  
Roger R. Nani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Near Infrared ◽  
Antibody Conjugates ◽  
In Vivo Pharmacokinetics

scholarly journals Near-Infrared Luciferin Analogs for In Vivo Optical Imaging

2021 ◽  
Author(s):  
Ryohei Saito-Moriya ◽  
Rika Obata ◽  
Shojiro A. Maki
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
Bioluminescence Imaging ◽  
Imaging System ◽  
Biological Tissues ◽  
Nir Light ◽  
In Vivo Bioluminescence Imaging ◽  
Firefly Bioluminescence ◽  
In Vivo Optical Imaging

The firefly bioluminescence reaction has been exploited for in vivo optical imaging in life sciences. To develop highly sensitive bioluminescence imaging technology, many researchers have synthesized luciferin analogs and luciferase mutants. This chapter first discusses synthetic luciferin analogs and their structure–activity relationships at the luminescence wavelength of the firefly bioluminescence reaction. We then discuss the development of luciferin analogs that produce near-infrared (NIR) light. Since NIR light is highly permeable for biological tissues, NIR luciferin analogs might sensitively detect signals from deep biological tissues such as the brain and lungs. Finally, we introduce two NIR luciferin analogs (TokeOni and seMpai) and a newly developed bioluminescence imaging system (AkaBLI). TokeOni can detect single-cell signals in mouse tissue and luminescence signals from marmoset brain, whereas seMpai can detect breast cancer micro-metastasis. Both reagents are valid for in vivo bioluminescence imaging with high sensitivity.

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