Continuous In Situ Seed Generation through the Integration of a Mixed Suspension Mixed Product Removal and an Oscillatory Baffled Crystallizer for the Control of Crystal Size Distribution and Polymorphic Form

2021 ◽  
Author(s):  
Wei-Lee Wu ◽  
Joseph A. Oliva ◽  
Shivani Kshirsagar ◽  
Christopher L. Burcham ◽  
Zoltan K. Nagy
Keyword(s):  
Size Distribution ◽  
Crystal Size ◽  
Polymorphic Form ◽  
Crystal Size Distribution ◽  
Mixed Product ◽  
Product Removal ◽  
Mixed Suspension

Mixed suspension - mixed product removal crystallization kinetics: Effect of the method of supersaturation generation

1987 ◽  
Vol 52 (1) ◽  
pp. 72-80 ◽  
Author(s):  
Stanislav Žáček ◽  
Jaroslav Nývlt ◽  
John William Mullin
Keyword(s):  
Kinetic Data ◽  
Crystal Size ◽  
Crystallization Kinetic ◽  
Alcohol Concentration ◽  
Aluminium Sulphate ◽  
Salting Out ◽  
Mixed Product ◽  
Continuous Crystallization ◽  
Product Removal ◽  
Mixed Suspension

Three methods of continuous crystallization of potassium aluminium sulphate have been compared: crystallization by cooling, precipitation from solutions of component salts (potassium sulphate and aluminium sulphate) and salting-out with ethanol. Crystal size distribution of the products has been used to obtain crystallization kinetic data in two parallel ways, viz. using the concept of population balance and that of mass oversize distribution, both of which led to similar conclusions. The results of cooling and precipitation are comparable, but crystallization by salting-out with ethanol leads to smaller crystals and the results strongly depend on the alcohol concentration, which can be explained by the influence of micromixing.

scholarly journals Tunable Protein Crystal Size Distribution via Continuous Slug-Flow Crystallization with Spatially Varying Temperature

CrystEngComm ◽  
2021 ◽  
Author(s):  
Nicholas Mozdzierz ◽  
Moo Sun Hong ◽  
Yongkyu Lee ◽  
Moritz Benisch ◽  
Mo Jiang ◽  
...  
Keyword(s):  
Product Quality ◽  
Size Distribution ◽  
Slug Flow ◽  
Crystal Size ◽  
Quality Attributes ◽  
Crystal Size Distribution ◽  
Protein Crystal ◽  
Manufacturing Cost ◽  
Spatially Varying

Accompanied with the growth of the biopharmaceuticals market has been an interest in developing processes with increased control of product quality attributes at low manufacturing cost, with one of the...

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