scholarly journals Marine and Anthropogenic Bromopyrroles Alter Cellular Ca2+ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca2+-ATPase

2021 ◽  
Author(s):  
Jing Zheng ◽  
Shane Antrobus ◽  
Wei Feng ◽  
Trevor N. Purdy ◽  
Bradley S. Moore ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Neuronal Networks

scholarly journals Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels

2018 ◽  
Vol 94 (1) ◽  
pp. 722-730 ◽  
Author(s):  
Takashi Murayama ◽  
Nagomi Kurebayashi ◽  
Mari Ishigami-Yuasa ◽  
Shuichi Mori ◽  
Yukina Suzuki ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
High Throughput ◽  
High Throughput Screening

cADP-ribose releases Ca2+ from cardiac sarcoplasmic reticulum independently of ryanodine receptor

1997 ◽  
Vol 273 (3) ◽  
pp. H1082-H1089 ◽  
Author(s):  
P. Lahouratate ◽  
J. Guibert ◽  
J. F. Faivre
Keyword(s):  
Endoplasmic Reticulum ◽  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Sea Urchin ◽  
Calcium Release ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Cardiac Sarcoplasmic Reticulum ◽  
Consistent Effect ◽  
Cyclic Adp Ribose

Cyclic ADP-ribose (cADPR), an endogenous metabolite of beta-NAD+, activates Ca2+ release from endoplasmic reticulum in sea urchin eggs via the ryanodine receptor (RyR) pathway. A similar role has been proposed in cardiac sarcoplasmic reticulum (SR), although this remains controversial. We therefore investigated the ability of cADPR to induce Ca2+ release from canine cardiac SR microsomes using fluo 3 to monitor extravesicular Ca2+ concentration. We found that cADPR induced Ca2+ release in a concentration-dependent manner, whereas neither its precursor, NAD+, nor its metabolite, ADP-ribose, elicited a consistent effect. In addition, an additive effect on calcium release between cADPR and 9-Me-7-Br-eudistomin-D (MBED), an activator of RyR, was found as well as no cross-desensitization between cADPR and MBED. Specific blockers of the RyR did not abolish the cADPR-induced Ca2+ release. These results provide evidence for cADPR-induced Ca2+ release from dog cardiac SR via a novel mechanism which is independent of RyR activation.

scholarly journals Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic β cell

2018 ◽  
Vol 294 (1) ◽  
pp. 168-181 ◽  
Author(s):  
Wataru R. Yamamoto ◽  
Robert N. Bone ◽  
Paul Sohn ◽  
Farooq Syed ◽  
Christopher A. Reissaus ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Ryanodine Receptor ◽  
Pancreatic Β Cell ◽  
Receptor Function ◽  
Β Cell

scholarly journals Nateglinide Stimulates Ca2+ Release from Endoplasmic Reticulum via Ryanodine Receptor Type 1

2008 ◽  
Vol 20 (4) ◽  
pp. 199-208
Author(s):  
Yusuke UBUKATA ◽  
Hideto OYAMADA ◽  
Toshiko YAMAZAWA ◽  
Takashi MURAYAMA ◽  
Mayumi TSUJI ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Receptor Type

scholarly journals Search for Type 2 Ryanodine Receptor Inhibitor by Monitoring Endoplasmic Reticulum Ca2+

2018 ◽  
Vol 114 (3) ◽  
pp. 116a
Author(s):  
Mai Tamura ◽  
Nagomi Kurebayashi ◽  
Takashi Murayama ◽  
Shuichi Mori ◽  
Mari Ishigami-Yuasa ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Receptor Inhibitor
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