scholarly journals Toxicokinetics of Perfluorinated Alkyl Acids Influences Their Toxic Potency in the Zebrafish Embryo (Danio rerio)

2019 ◽  
Vol 53 (7) ◽  
pp. 3898-3907 ◽  
Author(s):  
Carolina Vogs ◽  
Gunnar Johanson ◽  
Markus Näslund ◽  
Sascha Wulff ◽  
Marcus Sjödin ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Zebrafish Embryo ◽  
Perfluorinated Alkyl Acids

scholarly journals The emerging contaminant 3,3′-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio)

2019 ◽  
Vol 254 ◽  
pp. 113027 ◽  
Author(s):  
Monika A. Roy ◽  
Karilyn E. Sant ◽  
Olivia L. Venezia ◽  
Alix B. Shipman ◽  
Stephen D. McCormick ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Zebrafish Embryo ◽  
Emerging Contaminant ◽  
Cyp1a Activity

Suborganismic and organismic effects of aldicarb and its metabolite aldicarb-sulfoxide to the zebrafish embryo (Danio rerio)

Chemosphere ◽  
2007 ◽  
Vol 68 (4) ◽  
pp. 751-760 ◽  
Author(s):  
Eberhard Küster ◽  
Rolf Altenburger
Keyword(s):  
Danio Rerio ◽  
Zebrafish Embryo

scholarly journals Evaluation of acute toxicity of an aqueous extract of irradiated Labisia pumila on zebrafish embryo (Danio rerio)

2020 ◽  
Vol 23 (1and2) ◽  
pp. 42
Author(s):  
Santhra Segaran Balan ◽  
Punithaamalar Manokaram ◽  
Norshafarina Shari ◽  
Mahathir Mohd Uzid ◽  
Hasnah Bahari ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Danio Rerio ◽  
Zebrafish Embryo ◽  
Labisia Pumila

LETHAL CONCENTRATION 50% OF PATCHOULI OIL (Pogostemon cablin) TOWARDS ZEBRAFISH EMBRYO (Danio rerio)

2020 ◽  
Vol 3 (2) ◽  
pp. 1
Author(s):  
Romel Ciptoadi Wijaya
Keyword(s):  
Danio Rerio ◽  
Zebrafish Embryo ◽  
Toxicity Testing ◽  
Positive Control ◽  
Negative Control ◽  
Lethal Concentration ◽  
Zebrafish Embryos ◽  
Treatment Groups ◽  
Precise Prediction ◽  
Loss Of Appetite

Preface :Patchouli Oil requires toxicity testing for safety before we can use it widely. It causes side effects such as nausea, vomiting and loss of appetite in some people. Determination of lethal concentration 50% (LC50) in the early stages of zebrafish embryos development will provide an easier, faster and precise prediction of toxicity. At a certain dose, it can cause impairment and death toward organisms. Therefore, the aim of this study was to determine LC50 of Patchouli Oil in carboximethyl cellulose emulsifier towards zebrafish embryo (Danio rerio).Method :Laboratory experimental study was using zebrafish embryos at 2 hours post fertilization. The total of 160 embryos were used and divided into 8 groups, i.e.; Negative control (KN) was given the embryonic fluid, positive control 1 was given 5000 ppm of patchouli oil (KP1), positive control was given 5000 ppm of CMC (KP2), and 5 treatment groups, i.e.; concentration of 10 ppm (P1), 30 ppm (P2), 60 ppm (P3), 90 ppm (P4) and 120 ppm (P5) of Patchouli oil which was emulsified in CMC. The study was conducted with 3 times repetition. Data collection was done by calculating total of embryo’s deaths for each treatment at 24-72 hours of exposure. Data were analyzed using Regression Probit Analysis.Results :Mortality in the group of KN was 1.6%, KP1 was 98.3% and KP2 was 0%. Meanwhile in the treatment group of P1, P2, P3, P4 and P5 respectively were 0%, 5%, 10%, 25%, and 50%.Conclusion :Based on these results, Lethal Concentration 50% of Patchouli Oil in CMC emulsifier towards zebrafish embryo is 120 ppm.

scholarly journals The centriolar satellite protein Cfap53/Ccdc11 facilitates the formation of the first zygotic microtubule organizing center in the zebrafish embryo

2020 ◽  
Author(s):  
Sven Willekers ◽  
Federico Tessadori ◽  
Babet van der Vaart ◽  
Heiko Henning ◽  
Riccardo Stucchi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Danio Rerio ◽  
Mitotic Spindle ◽  
Sperm Cell ◽  
Zebrafish Embryo ◽  
Animal Species ◽  
Microtubule Organizing Center ◽  
Microtubule Network ◽  
Cell Divisions ◽  
Organizing Center

AbstractIn embryos from most animal species a zygotic centrosome is assembled by the centriole derived from the sperm cell and pericentriolar proteins present in the oocyte. This zygotic centrosome acts as a microtubule organizing center (MTOC) to assemble the mitotic spindle in the first and all subsequent cell divisions. As MTOC formation has been studied mainly in adult cells, very little is known about the formation of the first zygotic MTOC. Here we find that zebrafish (Danio rerio) embryos lacking maternal or paternal Cfap53, a centriolar satellite protein, arrest during the first cell cycle due to a failure in proper formation of the mitotic spindle. During the first cell cycle Cfap53 co-localizes with γ-tubulin and other centrosomal and centriolar satellite proteins to the very large MTOC. Furthermore, we find that γ-tubulin localization to the MTOC is impaired in the absence of Cfap53 or when the microtubule network is disrupted. Based on these results we propose a model in which maternal and paternal Cfap53 participates in the organization of the first zygotic MTOC of the embryo. Once the zygotic MTOC is formed, Cfap53 is dispensable for MTOC formation and integrity in subsequent cell divisions.

Acute exposure of zebrafish embryo (Danio rerio) to flutolanil reveals its developmental mechanism of toxicity via disrupting the thyroid system and metabolism

2018 ◽  
Vol 242 ◽  
pp. 1157-1165 ◽  
Author(s):  
Miaomiao Teng ◽  
Wentao Zhu ◽  
Dezhen Wang ◽  
Jin Yan ◽  
Suzhen Qi ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Zebrafish Embryo ◽  
Acute Exposure ◽  
Developmental Mechanism ◽  
Mechanism Of Toxicity
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