Epicatechin Adducting with 5-Hydroxymethylfurfural as an Inhibitory Mechanism against Acrylamide Formation in Maillard Reactions

SummaryInteractions between tranexamic acid and protein were studied in respect of the antifibrinolytic actions of tranexamic acid. Tranexamic acid did neither show any interaction with fibrinogen or fibrin, nor was incorporated into cross-linked fibrin structure by the action of factor XIII. On the other hand, tranexamic acid bound to human plasmin with a dissociation constant of 3.5 × 10−5 M, which was very close to the inhibition constant (3.6 × 10−5 M) for this compound in inhibiting plasmin-induced fibrinolysis. The binding site of tranexamic acid on plasmin was not the catalytic site of plasmin, because TLCK-blocked plasmin also showed a similar affinity to tranexamic acid (the dissociation constant, 2.9–4.8 × 10−5 M).In the binding studies with the highly purified plasminogen and TLCK-plasmin preparations which were obtained by affinity chromatography on lysine-substituted Sepharose, the molar binding ratio was shown to be 1.5–1.6 moles tranexamic acid per one mole protein.On the basis of these and other findings, a model for the inhibitory mechanism of tranexamic acid is presented.

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Maillard Reactions in Chemistry, Food and Health

10.1533/9781845698393 ◽

1994 ◽

Keyword(s):

Maillard Reactions

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Faculty Opinions recommendation of Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1091120.544512 ◽

2007 ◽

Author(s):

Kristin Artinger

Keyword(s):

Inhibitory Mechanism ◽

Prechordal Mesoderm

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Inhibitory mechanism of 5-fluoroorotate action in rat liver

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19710271 ◽

1971 ◽

Vol 36 (1) ◽

pp. 271-280 ◽

Cited By ~ 2

Author(s):

A. Čihák ◽

H. C. Pitot

Keyword(s):

Rat Liver ◽

Inhibitory Mechanism

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An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenicEscherichia coli

Journal of Peptide Science ◽

10.1002/psc.3149 ◽

2019 ◽

Vol 25 (3) ◽

Cited By ~ 1

Author(s):

Mariano Larzábal ◽

Hector A. Baldoni ◽

Fernando D. Suvire ◽

Lucrecia M. Curto ◽

Gabriela E. Gomez ◽

...

Keyword(s):

Mechanism Of Action ◽

Coiled Coil ◽

Secretion System ◽

Inhibitory Mechanism ◽

Type Three Secretion System ◽

Type Three Secretion

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Vitamin A and E Homologues Impacting the Fate of Acrylamide in Equimolar Asparagine-Glucose Model System

Antioxidants ◽

10.3390/antiox10070993 ◽

2021 ◽

Vol 10 (7) ◽

pp. 993

Author(s):

Su Lee Kuek ◽

Azmil Haizam Ahmad Tarmizi ◽

Raznim Arni Abd Razak ◽

Selamat Jinap ◽

Maimunah Sanny

Keyword(s):

Vitamin E ◽

Linear Regression ◽

Vitamin A ◽

Regression Model ◽

Linear Regression Model ◽

Model System ◽

Concentration Increase ◽

Acrylamide Formation ◽

Β Carotene

This study aims to evaluate the influence of Vitamin A and E homologues toward acrylamide in equimolar asparagine-glucose model system. Vitamin A homologue as β-carotene (BC) and five Vitamin E homologues, i.e., α-tocopherol (AT), δ-tocopherol (DT), α-tocotrienol (ATT), γ-tocotrienol (GTT), and δ-tocotrienol (DTT), were tested at different concentrations (1 and 10 µmol) and subjected to heating at 160 °C for 20 min before acrylamide quantification. At lower concentrations (1 µmol; 431, 403, 411 ppm, respectively), AT, DT, and GTT significantly increase acrylamide. Except for DT, enhancing concentration to 10 µmol (5370, 4310, 4250, 3970, and 4110 ppm, respectively) caused significant acrylamide formation. From linear regression model, acrylamide concentration demonstrated significant depreciation over concentration increase in AT (Beta = −83.0, R2 = 0.652, p ≤ 0.05) and DT (Beta = −71.6, R2 = 0.930, p ≤ 0.05). This study indicates that different Vitamin A and E homologue concentrations could determine their functionality either as antioxidants or pro-oxidants.

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