Inhibition of P2X7R–NLRP3 Inflammasome Activation by Pleurotus citrinopileatus: A Possible Protective Role in Alcoholic Hepatosteatosis

2018 ◽  
Vol 66 (50) ◽  
pp. 13183-13190 ◽  
Author(s):  
Xia Li ◽  
Quan Jin ◽  
Yu Zhang ◽  
Yan-Ling Wu ◽  
Cheng-Min Jin ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Protective Role ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Pleurotus Citrinopileatus

scholarly journals DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Ming Yang ◽  
Shilu Luo ◽  
Na Jiang ◽  
Xi Wang ◽  
Yachun Han ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nlrp3 Inflammasome ◽  
Protective Role ◽  
Tubular Damage ◽  
Inflammasome Activation ◽  
Compound C ◽  
Nlrp3 Inflammasome Activation ◽  
Amp Activated Protein Kinase ◽  
Relationship Of ◽  
The Relationship

NLRP3-mediated inflammation is closely related to the pathological progression of diabetic nephropathy (DN). DsbA-L, an antioxidant enzyme, plays a protective role in a variety of diseases by inhibiting ER stress and regulating metabolism. However, the relationship of DsbA-L with inflammation, especially the NLRP3 inflammasome, has not been examined. In this study, we note that activation of the NLRP3 inflammasome and exacerbated fibrosis were observed in the kidneys of diabetic DsbA-L-knockout mice and were accompanied by decreased phosphorylation of AMP-activated protein kinase (AMPK). Moreover, correlation analysis shows that the phosphorylation of AMPK was negatively correlated with NLRP3 expression and tubular damage. In addition, the decreased AMPK phosphorylation and NLRP3 activation induced by high glucose (HG) in HK-2 cells could be alleviated by the overexpression of DsbA-L. Interestingly, the protective effect of DsbA-L was eliminated after treatment with compound C, a well-known AMPK inhibitor. Our findings suggest that DsbA-L inhibits NLRP3 inflammasome activation by promoting the phosphorylation of AMPK.

scholarly journals Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries

2018 ◽  
Vol 188 (12) ◽  
pp. 2948-2959 ◽  
Author(s):  
Xinxu Yuan ◽  
Owais M. Bhat ◽  
Nan Meng ◽  
Hannah Lohner ◽  
Pin-Lan Li
Keyword(s):  
Coronary Arteries ◽  
Nlrp3 Inflammasome ◽  
Protective Role ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Medial Thickening
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