Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

2021 ◽  
Author(s):  
Claudia Schmidt ◽  
Tomer Babu ◽  
Hana Kostrhunova ◽  
Annika Timm ◽  
Uttara Basu ◽  
...  
Keyword(s):  
Combretastatin A4

Selectively Potentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia‐Activated Prodrug Tirapazamine Therapy for Metastatic Tumors

2019 ◽  
Vol 31 (11) ◽  
pp. 1805955 ◽  
Author(s):  
Shengcai Yang ◽  
Zhaohui Tang ◽  
Chenyang Hu ◽  
Dawei Zhang ◽  
Na Shen ◽  
...  
Keyword(s):  
Metastatic Tumors ◽  
Combretastatin A4

Combretastatin A4 phosphate: a novel vascular disrupting agent

2010 ◽  
Vol 6 (8) ◽  
pp. 1219-1228 ◽  
Author(s):  
Govardhanan Nagaiah ◽  
Scot C Remick
Keyword(s):  
Vascular Disrupting Agent ◽  
Combretastatin A4 ◽  
Vascular Disrupting

Heme Oxygenase and the Novel Tumour-Specific Anti-Vascular Compound Combretastatin A4-Phosphate

2002 ◽  
pp. 303-312
Author(s):  
Amel F. Khelifi ◽  
Vivien E. Prise ◽  
Roberta Foresti ◽  
James E. Clark ◽  
Chryso Kanthou ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
The Novel ◽  
Combretastatin A4

pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma

Biomaterials ◽  
2013 ◽  
Vol 34 (29) ◽  
pp. 7181-7190 ◽  
Author(s):  
Yinsong Wang ◽  
Hongli Chen ◽  
Yuanyuan Liu ◽  
Jing Wu ◽  
Ping Zhou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Combination Therapy ◽  
Ph Sensitive ◽  
Combretastatin A4

scholarly journals Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects

2019 ◽  
Vol Volume 14 ◽  
pp. 1789-1804 ◽  
Author(s):  
Hong Jiang ◽  
Zhi-Peng Li ◽  
Gui-Xiang Tian ◽  
Rui-Yan Pan ◽  
Chong-Mei Xu ◽  
...  
Keyword(s):  
Antitumor Effects ◽  
Combretastatin A4

Targeted‐nanoliposomal combretastatin A4 (CA‐4) as an efficient antivascular candidate in the metastatic cancer treatment

2019 ◽  
Vol 234 (9) ◽  
pp. 14721-14733 ◽  
Author(s):  
Maryam Ebrahimi Nik ◽  
Amir Abbas Momtazi‐Borojeni ◽  
Parvin Zamani ◽  
Jamshid Gholizadeh Navashenaq ◽  
Mehrdad Iranshahi ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Metastatic Cancer ◽  
Combretastatin A4

Synthesis, X-Ray Crystal Structure and Tubulin- Binding Properties of a Benzofuran Analogue of the Potent Cytotoxic Agent Combretastatin A4

1999 ◽  
Vol 52 (8) ◽  
pp. 767 ◽  
Author(s):  
Martin G. Banwell ◽  
Bernard L. Flynn ◽  
Ernest Hamel ◽  
Anthony C. Willis
Keyword(s):  
Crystal Structure ◽  
Cytotoxic Agent ◽  
Binding Agent ◽  
Binding Properties ◽  
Antimitotic Agent ◽  
X Ray ◽  
Combretastatin A4 ◽  
Tubulin Binding

The benzofuran (4), a ring-fused analogue of the potent antimitotic agent combretastatin A4 (1), has been prepared by a convergent route involving 5-endo-dig iodocyclization of o-hydroxytolan (5) as the key step. Compound (4), which has been characterized crystallographically as well as spectroscopically, is inactive as a tubulin-binding agent.

Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo

Tumor Biology ◽  
2015 ◽  
Vol 36 (11) ◽  
pp. 8499-8510 ◽  
Author(s):  
Nan Yao ◽  
Ke Ren ◽  
Cuihua Jiang ◽  
Meng Gao ◽  
Dejian Huang ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Vasculogenic Mimicry ◽  
Combretastatin A4 ◽  
Phosphate Treatment ◽  
Carcinoma Tumor
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