Redox-Sensitive Cerium Oxide Nanoparticles Protect Human Keratinocytes from Oxidative Stress Induced by Glutathione Depletion

Langmuir ◽  
2016 ◽  
Vol 32 (46) ◽  
pp. 12202-12211 ◽  
Author(s):  
Ragini Singh ◽  
Ajay S. Karakoti ◽  
William Self ◽  
Sudipta Seal ◽  
Sanjay Singh
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Human Keratinocytes ◽  
Glutathione Depletion ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1565 ◽  
Author(s):  
Turin-Moleavin ◽  
Fifere ◽  
Lungoci ◽  
Rosca ◽  
Coroaba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Iron Oxide ◽  
Cerium Oxide ◽  
Chemical Activation ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

Cerium oxide nanoparticles protects against acrylamide induced toxicity in HepG2 cells through modulation of oxidative stress

2018 ◽  
Vol 42 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Aala Azari ◽  
Mohammad Shokrzadeh ◽  
Ehsan Zamani ◽  
Nahid Amani ◽  
Fatemeh Shaki
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Hepg2 Cells ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Cerium oxide nanoparticles induce oxidative stress in the sediment-dwelling amphipodCorophium volutator

2015 ◽  
Vol 10 (4) ◽  
pp. 480-487 ◽  
Author(s):  
Yuktee Dogra ◽  
Kenton P. Arkill ◽  
Christine Elgy ◽  
Bjorn Stolpe ◽  
Jamie Lead ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum

2020 ◽  
Vol 24 (4) ◽  
pp. 251-256
Author(s):  
Adel Sepanjnia ◽  
Hassan Ghasemi ◽  
Roohollah Mohseni ◽  
Akram Ranjbar ◽  
Fatemeh Shabani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

scholarly journals Exacerbation of Coagulation and Cardiac Injury in Rats with Cisplatin-Induced Nephrotoxicity Following Intratracheal Instillation of Cerium Oxide Nanoparticles

2021 ◽  
Vol 55 (1) ◽  
pp. 1-16
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cerium Oxide ◽  
Cardiac Injury ◽  
Heart Weight ◽  
Cerium Oxide Nanoparticles ◽  
Saline Control ◽  
Enzyme Linked Immunosorbent Assay ◽  
Oxide Nanoparticles ◽  
Markers Of Inflammation

BACKGROUND/AIMS: Exposure to particulate air pollution is associated with increased cardiovascular morbidity and mortality. These effects are particularly aggravated in patients with pre-existing kidney diseases. Cerium oxide nanoparticles (CNPs), used as diesel fuel additives, are emitted in vehicle exhaust and affect humans when inhaled. However, thrombotic and cardiac injury resulting from pulmonary exposure to CNPs in experimental acute kidney injury (AKI) is not fully understood. The objective of the present study was to evaluate the thrombotic and cardiac injury effects of CNPs in a rat model of AKI. METHODS: AKI was induced in rats by a single intraperitoneal injection of cisplatin (CDDP, 6 mg/kg). Six days after injection, rats were intratracheally (i.t.) instilled with either CNPs (1 mg/kg) or saline (control), and various cardiovascular variables and markers of inflammation, oxidative stress and DNA injury were assessed by enzyme linked immunosorbent assay, colorimetric assay, single-cell gel electrophoresis assay and immunohistochemistry, the following day. RESULTS: Compared with individual CDDP or CNPs treatments, the combined CDDP + CNPs treatment elevated significantly the coagulation function, relative heart weight, and troponin I, lactate dehydrogenase, interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and total nitric oxide levels in the plasma. In heart homogenates, the combination of CDDP and CNPs induced a significant increase in IL-6, TNFα, catalase, and glutathione. Furthermore, significantly more DNA damage was observed in this group than in the CDDP or CNPs groups. Immunohistochemical analysis of the heart revealed that expression of nuclear factor erythroid-derived 2-like 2 (Nrf2) and glutathione peroxidase by cardiac myocytes and endothelial cells was increased in the CDDP + CNPs group more than in either CDDP or CNPs group. CONCLUSION: I.t. administration of CNPs in rats with AKI exacerbated systemic inflammation, oxidative stress, and coagulation events. It also aggravated cardiac inflammation, DNA damage, and Nrf2 expression.

scholarly journals Cerium Oxide Nanoparticles Protect Cardiac Progenitor Cells from Oxidative Stress

ACS Nano ◽  
2012 ◽  
Vol 6 (5) ◽  
pp. 3767-3775 ◽  
Author(s):  
Francesca Pagliari ◽  
Corrado Mandoli ◽  
Giancarlo Forte ◽  
Eugenio Magnani ◽  
Stefania Pagliari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Progenitor Cells ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Cardiac Progenitor Cells
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