Hydrogen Peroxide-Triggered Conversion of Boronic Acid-Appended Insulin into Insulin and Its Application as a Glucose-Responsive Insulin Formulation

2021 ◽  
Author(s):  
Hinako Kikuchi ◽  
Yuki Nakamura ◽  
Chika Inoue ◽  
Sayaka Nojiri ◽  
Miho Koita ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Boronic Acid ◽  
Insulin Formulation

A near-infrared fluorescent aza-bodipy probe for dual-wavelength detection of hydrogen peroxide in living cells

The Analyst ◽  
2016 ◽  
Vol 141 (8) ◽  
pp. 2380-2383 ◽  
Author(s):  
Jingjing Xu ◽  
Jingying Zhai ◽  
Yanmei Xu ◽  
Jingwei Zhu ◽  
Yu Qin ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Boronic Acid ◽  
Near Infrared ◽  
High Selectivity ◽  
Living Cells ◽  
Dual Wavelength ◽  
Biological Processes ◽  
Wavelength Detection ◽  
Intracellular Hydrogen Peroxide

A boronic acid functionalized aza-borondipyrromethene dye (azaBDPBA) was applied to the dual-wavelength detection of hydrogen peroxide with high selectivity, which was loaded into cells to indicate the alteration of intracellular hydrogen peroxide during biological processes.

scholarly journals Boronic ester derivative-dependent activity of parthenolide analogues

2021 ◽  
Author(s):  
Xingjian Li ◽  
George Williams ◽  
Alex Quy ◽  
Yiming Zhao ◽  
Louise Male ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Biological Activity ◽  
Chronic Lymphocytic Leukaemia ◽  
Boronic Acid ◽  
Lymphocytic Leukaemia ◽  
Ester Derivative ◽  
Boronic Ester ◽  
Dependent Activity ◽  
Oxidation By Hydrogen Peroxide

Four parthenolide derived prodrugs, containing different boronic ester moieties, were synthesised, their drug-like properties were calculated and their activity against chronic lymphocytic leukaemia (CLL) MEC1 cells measured. Differences in the clogP, the propensity towards oxidation by hydrogen peroxide, the affinity of the associated diols to a model boronic acid and the biological activity against MEC1 cells were contrasted, and it was found that the propensity for oxidation correlated to biological activity.

Synthesis of Graphene Oxide Frameworks and their Application in Electrocatalytic Preparation of Hydrogen Peroxide

2015 ◽  
Vol 1090 ◽  
pp. 43-49 ◽  
Author(s):  
Li Na Zhou ◽  
Han Zhao ◽  
Yuan Liu ◽  
Jing Li ◽  
Hao Fei Shi ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Graphene Oxide ◽  
Boronic Acid ◽  
Flow Reactor ◽  
Rotating Disk ◽  
Production Method ◽  
Rotating Disk Electrode ◽  
Disk Electrode ◽  
Hydrogen Peroxide Production ◽  
Graphene Oxide Sheets

The electrocatalytic performance of graphene oxide frameworks (GOFs) for producing hydrogen peroxide is reported. Three different GOFs are synthesized by interlinking the graphene oxide sheets with different boronic acid deviates through the hydrothermal method and their electrochemical performance are investigated via cyclic voltammetry (CV) and rotating disk electrode (RDE) experiments. Through these electrochemical experiments, we find GOFs favor a 2e-reduction pathway and perform high activity and selectivity in the hydrogen peroxide production process. Taking advantage of these catalysts for the electrochemical synthesis of hydrogen peroxide has the potential to establish a safe, sustainable, and cheap flow-reactor-based production method.

scholarly journals Boronic ester derivative-dependent activity of parthenolide analogues

2021 ◽  
Author(s):  
Xingjian Li ◽  
George Williams ◽  
Alex Quy ◽  
Yiming Zhao ◽  
Louise Male ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Biological Activity ◽  
Chronic Lymphocytic Leukaemia ◽  
Boronic Acid ◽  
Lymphocytic Leukaemia ◽  
Ester Derivative ◽  
Boronic Ester ◽  
Dependent Activity ◽  
Oxidation By Hydrogen Peroxide

Four parthenolide derived prodrugs, containing different boronic ester moieties, were synthesised, their drug-like properties were calculated and their activity against chronic lymphocytic leukaemia (CLL) MEC1 cells measured. Differences in the clogP, the propensity towards oxidation by hydrogen peroxide, the affinity of the associated diols to a model boronic acid and the biological activity against MEC1 cells were contrasted, and it was found that the propensity for oxidation correlated to biological activity.

A simple boronic acid-based fluorescent probe for selective detection of hydrogen peroxide in solutions and living cells

2018 ◽  
Vol 81 ◽  
pp. 362-366 ◽  
Author(s):  
Jialing Han ◽  
Chengyu Chu ◽  
Guoxiu Cao ◽  
Wuxiang Mao ◽  
Sen Wang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Boronic Acid ◽  
Living Cells ◽  
Selective Detection

A boronic acid based intramolecular charge transfer probe for colorimetric detection of hydrogen peroxide

2019 ◽  
Vol 60 (46) ◽  
pp. 151258 ◽  
Author(s):  
Rajib Choudhury ◽  
Andrew T. Ricketts ◽  
Dennis G. Molina ◽  
Pratikshya Paudel
Keyword(s):  
Hydrogen Peroxide ◽  
Charge Transfer ◽  
Boronic Acid ◽  
Intramolecular Charge Transfer ◽  
Colorimetric Detection
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