Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Polyphenolic Acids Impact Safety of Popular Salvianolic Acid A/B-Containing Drugs and Herbal Products

2017 ◽  
Vol 14 (9) ◽  
pp. 2952-2966 ◽  
Author(s):  
Guo Ma ◽  
Ying Zhang ◽  
Wenyan Chen ◽  
Zhifang Tang ◽  
Xiaoming Xin ◽  
...  
Keyword(s):  
Herbal Products ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Polyphenolic Acids

scholarly journals Bioactive Phenolic Compounds from the Roots of Danshen (Salvia miltiorrhiza)

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301
Author(s):  
Nguyen Huu Tung ◽  
Le Quoc Hung ◽  
Ha Van Oanh ◽  
Duong Thi Ly Huong ◽  
Phuong Thien Thuong ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Methyl Ester ◽  
Ethyl Ester ◽  
Rosmarinic Acid ◽  
Salvia Miltiorrhiza ◽  
Chemical Constituents ◽  
Acid Methyl Ester ◽  
Acid Ethyl Ester ◽  
Salvianolic Acid ◽  
Salvianolic Acid A

Danshen ( Salvia miltiorrhiza Bunge) is one of the most used medicinal plants in the Oriental medicine and has been well studied for application in modern medicine. In our continuing study on chemical constituents of danshen cultivated in Vietnam, using chromatography separation resulted in the isolation of six phenolic compounds including a benzophenone, iriflophenone 2- O- α-L-rhamnopyranoside (1), and five phenolic acids including rosmarinic acid (2), rosmarinic acid methyl ester (3), rosmarinic acid ethyl ester (4), salvianolic acid A methyl ester (5) and salvianolic acid A ethyl ester (6) from the butanol portion of the danshen crude extract. Beside the typically main phenolic acid components, to our knowledge, iriflophenone 2- O- α-L-rhamnopyranoside (1) was first isolated from salvia sp. On biological testing, compound 1 showed strong antiproliferative activity on HL-60 leukemia cells with the IC50 of 8.9 μM; compounds 1 and 3–6 inhibited markedly nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells.

Effect of Salvianolic Acid A, a Depside from Roots ofSalvia miltiorrhiza, on Gastric H+, K+-ATPase

Planta Medica ◽  
1990 ◽  
Vol 56 (04) ◽  
pp. 360-363 ◽  
Author(s):  
Shigeru Murakami ◽  
Haruko Kijima ◽  
Yoshihiko Isobe ◽  
Makoto Muramatsu ◽  
Hironaka Aihara ◽  
...  
Keyword(s):  
Salvianolic Acid ◽  
Salvianolic Acid A

scholarly journals Salvianolic Acid A, as a Novel ETA Receptor Antagonist, Shows Inhibitory Effects on Tumor in Vitro

2016 ◽  
Vol 17 (8) ◽  
pp. 1244 ◽  
Author(s):  
Qiao Zhang ◽  
Shifeng Wang ◽  
Yangyang Yu ◽  
Shengnan Sun ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Inhibitory Effects ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Eta Receptor ◽  
Eta Receptor Antagonist
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