scholarly journals Stimuli-responsive nanofibers prepared from poly(N-isopropylacrylamide-acrylamide-vinylpyrrolidone) by electrospinning as an anticancer drug delivery

2013 ◽  
Vol 16 (6) ◽  
pp. 515-527 ◽  
Author(s):  
Roya Salehi ◽  
Mohammad Irani ◽  
Mohammad-Reza Rashidi ◽  
Abdolreza Aroujalian ◽  
Ahmadreza Raisi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery

Tumor Microenvironment Stimuli-Responsive Nanoparticles for Programmed Anticancer Drug Delivery

2020 ◽  
Vol 17 (5) ◽  
pp. 1516-1526 ◽  
Author(s):  
Nan Jia ◽  
Wenpan Li ◽  
Dan Liu ◽  
Shiyang Wu ◽  
Baohui Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drug ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery

Multi-stimuli-responsive nanomicelles fabricated using synthetic polymer polylysine conjugates for tumor microenvironment dependent drug delivery

2020 ◽  
Vol 8 (26) ◽  
pp. 5745-5755
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Nagendra Kalva ◽  
Kuen Hee Eom ◽  
Jae Ho Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drug ◽  
Tumor Targeting ◽  
Synthetic Polymer ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Temperature Responsive ◽  
Polymer Hybrid

A poly(lysine)-synthetic polymer hybrid nanomicelles were fabricated as promising platform for efficient tumor targeting and glutathione/pH/temperature-responsive anticancer drug delivery.

Peptide Sequence-Dominated Enzyme-Responsive Nanoplatform for Anticancer Drug Delivery

2019 ◽  
Vol 19 (1) ◽  
pp. 74-97 ◽  
Author(s):  
Yanan Li ◽  
Liping Du ◽  
Chunsheng Wu ◽  
Bin Yu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Peptide Sequence ◽  
Stimuli Responsive ◽  
Property A ◽  
Anticancer Drug Delivery ◽  
Microenvironmental Factors ◽  
Responsive Element

Enzymatic dysregulation in tumor and intracellular microenvironments has made this property a tremendously promising responsive element for efficient diagnostics, carrier targeting, and drug release. When combined with nanotechnology, enzyme-responsive drug delivery systems (DDSs) have achieved substantial advancements. In the first part of this tutorial review, changes in tumor and intracellular microenvironmental factors, particularly the enzymatic index, are described. Subsequently, the peptide sequences of various enzyme-triggered nanomaterials are summarized for their uses in various drug delivery applications. Then, some other enzyme responsive nanostructures are discussed. Finally, the future opportunities and challenges are discussed. In brief, this review can provide inspiration and impetus for exploiting more promising internal enzyme stimuli-responsive nanoDDSs for targeted tumor diagnosis and treatment.

scholarly journals Dual pH/Redox-Responsive Mixed Polymeric Micelles for Anticancer Drug Delivery and Controlled Release

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 176 ◽  
Author(s):  
Yongle Luo ◽  
Xujun Yin ◽  
Xi Yin ◽  
Anqi Chen ◽  
Lili Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Drug ◽  
Diblock Copolymers ◽  
Polymeric Micelles ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Amino Esters ◽  
Redox Responsive ◽  
Poly Ethylene

Stimuli-responsive polymeric micelles (PMs) have shown great potential in drug delivery and controlled release in cancer chemotherapy. Herein, inspired by the features of the tumor microenvironment, we developed dual pH/redox-responsive mixed PMs which are self-assembled from two kinds of amphiphilic diblock copolymers (poly(ethylene glycol) methyl ether-b-poly(β-amino esters) (mPEG-b-PAE) and poly(ethylene glycol) methyl ether-grafted disulfide-poly(β-amino esters) (PAE-ss-mPEG)) for anticancer drug delivery and controlled release. The co-micellization of two copolymers is evaluated by measurement of critical micelle concentration (CMC) values at different ratios of the two copolymers. The pH/redox-responsiveness of PMs is thoroughly investigated by measurement of base dissociation constant (pKb) value, particle size, and zeta-potential in different conditions. The PMs can encapsulate doxorubicin (DOX) efficiently, with high drug-loading efficacy. The DOX was released due to the swelling and disassembly of nanoparticles triggered by low pH and high glutathione (GSH) concentrations in tumor cells. The in vitro results demonstrated that drug release rate and cumulative release are obviously dependent on pH values and reducing agents. Furthermore, the cytotoxicity test showed that the mixed PMs have negligible toxicity, whereas the DOX-loaded mixed PMs exhibit high cytotoxicity for HepG2 cells. Therefore, the results demonstrate that the dual pH/redox-responsive PMs self-assembled from PAE-based diblock copolymers could be potential anticancer drug delivery carriers with pH/redox-triggered drug release, and the fabrication of stimuli-responsive mixed PMs could be an efficient strategy for preparation of intelligent drug delivery platform for disease therapy.

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