Ustethylin Biosynthesis Implies Phenethyl Derivative Formation in Aspergillus ustus

2020 ◽  
Vol 22 (20) ◽  
pp. 7837-7841 ◽  
Author(s):  
Liujuan Zheng ◽  
Yiling Yang ◽  
Haowen Wang ◽  
Aili Fan ◽  
Liping Zhang ◽  
...  
Keyword(s):  
2020 ◽  
Vol 164 ◽  
pp. 06015
Author(s):  
Kseniia Illarionova ◽  
Sergey Grigoryev

The aim of research was to characterize epiphyte micromycetes observed on variable cotton fibers accessions, to estimate the range of fiber destruction and select cotton, which were the most resistant to fungus damage. The accessions of differently colored Upland Cotton varieties (Gossypium hirsutum L.) evaluated: eleven cotton of natural green, twelve – of brown and eleven of conventional white color. Cotton plants have been grown in Sothern Federal District, RF. The fiber samples for the study were placed into a thermostat in sterile Petri dishes on moistened filter paper in order to stimulate the development of mycelium or sporulation of fungi naturally occurred on fibers. Incubation carried out in a thermostat at a +24-28 °C, humidity of 90-100% and exposed for 28 days. The samples examined with a microscope or binocular magnifier. Aspergillus ustus (Bainier), A. fumigatus Fresen., A. niger v. Tiegh., A. flavus Link, Penicillium aurantiogriseum Dierckx, P. notatum Westling, Rhizopus nigricans Ehrenb. and Alternaria alternata (Fuier) Keissler were detected. Compared with exposed white, accession of green and brown colors were significantly resistant to fungus. The mean of destruction (K) of white cotton varied up to 0.95, but colored accessions not exceeded 0.3 (initial destruction of the surface, not affecting internal fiber’s structure).


1946 ◽  
Vol 68 (4) ◽  
pp. 725-726 ◽  
Author(s):  
W. E. Doering ◽  
R. J. Dubos ◽  
D. S. Noyce ◽  
R. Dreyfus

Author(s):  
Salman A. Ahmed ◽  
Fiona E. Scott ◽  
Desmond J. Stenzel ◽  
Thomas J. Simpson ◽  
Richard N. Moore ◽  
...  
Keyword(s):  

ChemInform ◽  
2010 ◽  
Vol 27 (47) ◽  
pp. no-no
Author(s):  
M. A. HAYES ◽  
S. K. WRIGLEY ◽  
I. CHETLAND ◽  
E. E. REYNOLDS ◽  
A. M. AINSWORTH ◽  
...  

Author(s):  
Z. Kozakiewicz

Abstract A description is provided for Aspergillus ustus. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Found in all soil types (DOMSCH et al., 1980), but also isolated from radio equipment, polyurethane foam, flannel bag, sugar and fermented cocoa (CABI BIOSCIENCE, 1999). DISEASE: On man it has been implicated in a case of primary cutaneous infection following a liver transplant (STILLER et al., 1994), isolated from invasive aspergillosis (VERWEU et al., 1999) and disseminated aspergillosis (IWEN et al., 1998). GEOGRAPHICAL DISTRIBUTION: World-wide, but with preference for tropical and subtropical regions.


Author(s):  
Hanli Ruan ◽  
Xiaogang Peng ◽  
Shuang Zhou ◽  
Junjun Liu ◽  
Ying Gao ◽  
...  

Three pairs of novel heterodimeric polyketide enantiomers, (±)-usphenethylones A−C (1−3), were isolated from the culture extract of Aspergillus ustus 3.3904. Compounds 1−3 represent two unique heterodimerization patterns of a phenethyl...


2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Liujuan Zheng ◽  
Haowen Wang ◽  
Aili Fan ◽  
Shu-Ming Li

Abstract Oxepinamides are derivatives of anthranilyl-containing tripeptides and share an oxepin ring and a fused pyrimidinone moiety. To the best of our knowledge, no studies have been reported on the elucidation of an oxepinamide biosynthetic pathway and conversion of a quinazolinone to a pyrimidinone-fused 1H-oxepin framework by a cytochrome P450 enzyme in fungal natural product biosynthesis. Here we report the isolation of oxepinamide F from Aspergillus ustus and identification of its biosynthetic pathway by gene deletion, heterologous expression, feeding experiments, and enzyme assays. The nonribosomal peptide synthase (NRPS) OpaA assembles the quinazolinone core with d-Phe incorporation. The cytochrome P450 enzyme OpaB catalyzes alone the oxepin ring formation. The flavoenzyme OpaC installs subsequently one hydroxyl group at the oxepin ring, accompanied by double bond migration. The epimerase OpaE changes the d-Phe residue back to l-form, which is essential for the final methylation by OpaF.


ChemInform ◽  
2005 ◽  
Vol 36 (38) ◽  
Author(s):  
Teppei Kumemura ◽  
Tominari Choshi ◽  
Aki Hirata ◽  
Mitsuko Sera ◽  
Yohhei Takahashi ◽  
...  

1983 ◽  
Vol 80 (3) ◽  
pp. 408-411 ◽  
Author(s):  
Lawrence M. Weiss ◽  
William A. Thiemke

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