Maximizing Magnetic Resonance Contrast in Gd(III) Nanoconjugates: Investigation of Proton Relaxation in Zirconium Metal–Organic Frameworks

2020 ◽  
Vol 12 (37) ◽  
pp. 41157-41166 ◽  
Author(s):  
Shaunna M. McLeod ◽  
Lee Robison ◽  
Giacomo Parigi ◽  
Alyssa Olszewski ◽  
Riki J. Drout ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Metal Organic Frameworks ◽  
Proton Relaxation ◽  
Magnetic Resonance Contrast ◽  
Metal Organic ◽  
Resonance Contrast ◽  
Zirconium Metal

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Improved Method for In Vivo Magnetic Resonance Contrast Media Research

1991 ◽  
Vol 26 (1) ◽  
pp. 65-70 ◽  
Author(s):  
UDO P. SCHMIEDL ◽  
KENNETH R. MARAVILLA ◽  
JAMES A NELSON
Keyword(s):  
Magnetic Resonance ◽  
Contrast Media ◽  
Improved Method ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Media Research

Smart “Turn-on” Magnetic Resonance Contrast Agents Based on Aptamer-Functionalized Superparamagnetic Iron Oxide Nanoparticles

ChemBioChem ◽  
2007 ◽  
Vol 8 (14) ◽  
pp. 1675-1678 ◽  
Author(s):  
Mehmet Veysel Yigit ◽  
Debapriya Mazumdar ◽  
Hee-Kyung Kim ◽  
Jung Heon Lee ◽  
Boris Odintsov ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Turn On ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast

Block Co-polymeric Magnetic Resonance Contrast Agents

1994 ◽  
Vol 29 ◽  
pp. S217-S219 ◽  
Author(s):  
DEKANG SHEN ◽  
THOMAS FRITZ ◽  
GUAN-LI WU ◽  
BRENDA KULIK ◽  
DAVID PALESTRANT ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast

Application of arsenazo III in the preparation and characterization of an albumin-linked, gadolinium-based macromolecular magnetic resonance contrast agent

2006 ◽  
Vol 157 (2) ◽  
pp. 238-245 ◽  
Author(s):  
Tavarekere N. Nagaraja ◽  
Richard L. Croxen ◽  
Swayamprava Panda ◽  
Robert A. Knight ◽  
Kelly A. Keenan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agent ◽  
Arsenazo Iii ◽  
Magnetic Resonance Contrast Agent ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast

scholarly journals Mechanochemical and solvent-free assembly of zirconium-based metal–organic frameworks

2016 ◽  
Vol 52 (10) ◽  
pp. 2133-2136 ◽  
Author(s):  
Krunoslav Užarević ◽  
Timothy C. Wang ◽  
Su-Young Moon ◽  
Athena M. Fidelli ◽  
Joseph T. Hupp ◽  
...  
Keyword(s):  
Solid State ◽  
High Temperatures ◽  
Self Assembly ◽  
Metal Organic Frameworks ◽  
Accelerated Aging ◽  
Solvent Free ◽  
Catalytically Active ◽  
Metal Organic ◽  
Strong Acids ◽  
Zirconium Metal

Mechanochemistry and accelerated aging are new routes to zirconium metal–organic frameworks, yielding UiO-66 and catalytically active UiO-66-NH2 accessible on the gram scale through mild solid-state self-assembly, without strong acids, high temperatures or excess reactants.

CO Guest Interactions in SDB-Based Metal–Organic Frameworks: A Solid-State Nuclear Magnetic Resonance Investigation

Langmuir ◽  
2018 ◽  
Vol 34 (51) ◽  
pp. 15640-15649 ◽  
Author(s):  
Y. T. Angel Wong ◽  
Troy K. Babcock ◽  
Shoushun Chen ◽  
Bryan E. G. Lucier ◽  
Yining Huang
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Magnetic Resonance ◽  
Metal Organic Frameworks ◽  
Resonance Investigation ◽  
Nuclear Magnetic Resonance Investigation ◽  
Metal Organic ◽  
Magnetic Resonance Investigation ◽  
Nuclear Magnetic

scholarly journals Macromolecular and dendrimer-based magnetic resonance contrast agents

2010 ◽  
Vol 51 (7) ◽  
pp. 751-767 ◽  
Author(s):  
Ambika Bumb ◽  
Martin W. Brechbiel ◽  
Peter Choyke
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast

scholarly journals Synthesis and Evaluation of GdIII-Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen

2015 ◽  
Vol 54 (37) ◽  
pp. 10778-10782 ◽  
Author(s):  
Sangeeta Ray Banerjee ◽  
Ethel J. Ngen ◽  
Matthew W. Rotz ◽  
Samata Kakkad ◽  
Ala Lisok ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Prostate Specific Membrane Antigen ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Specific Membrane

A Boronated Metalloporphyrin for use in Neutron Capture Therapy and Magnetic Resonance Contrast Enhancement of Glioma

1993 ◽  
pp. 301-303 ◽  
Author(s):  
Stephen B. Kahl ◽  
Myoung-Seo Koo ◽  
Robert M. Straubinger ◽  
Leryang R. Huang ◽  
Robert J. Fiel ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement
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