Biological Effect of Differently Sized Tetrahedral Framework Nucleic Acids: Endocytosis, Proliferation, Migration, and Biodistribution

2021 ◽  
Author(s):  
Sirong Shi ◽  
Yanjing Li ◽  
Tao Zhang ◽  
Dexuan Xiao ◽  
Taoran Tian ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Biological Effect ◽  
Tetrahedral Framework

scholarly journals Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

2021 ◽  
Author(s):  
Mei Zhang ◽  
Xiaolin Zhang ◽  
Taoran Tian ◽  
Qi Zhang ◽  
Yuting Wen ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Gouty Arthritis ◽  
Inflammatory Activity ◽  
Tetrahedral Framework ◽  
Acute Gouty Arthritis ◽  
Anti Inflammatory

Tetrahedral framework nucleic acids regulate osteogenic differentiation potential of osteoporotic adipose-derived stem cells

2021 ◽  
Author(s):  
Tianyu Chen ◽  
Dexuan Xiao ◽  
Yanjing Li ◽  
Sirong Shi ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nucleic Acids ◽  
Osteogenic Differentiation ◽  
Adipose Derived Stem Cells ◽  
Differentiation Potential ◽  
Tetrahedral Framework

The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields

2021 ◽  
pp. 137-166
Author(s):  
Xiaolin Zhang ◽  
Yunfeng Lin
Keyword(s):  
Nucleic Acids ◽  
Drug Carrier ◽  
Tetrahedral Framework

PEGylated Protamine-Based Adsorbing Improves the Biological Properties and Stability of Tetrahedral Framework Nucleic Acids

2019 ◽  
Vol 11 (31) ◽  
pp. 27588-27597 ◽  
Author(s):  
Yichen Ge ◽  
Taoran Tian ◽  
Xiaoru Shao ◽  
Shiyu Lin ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Biological Properties ◽  
Tetrahedral Framework

scholarly journals MicroRNA‐214‐3p modified tetrahedral framework nucleic acids target survivin to induce tumour cell apoptosis

2019 ◽  
Vol 53 (1) ◽  
Author(s):  
Songhang Li ◽  
Yue Sun ◽  
Taoran Tian ◽  
Xin Qin ◽  
Shiyu Lin ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Tumour Cell ◽  
Cell Apoptosis ◽  
Tetrahedral Framework

Tetrahedral Framework Nucleic Acids Loading Ampicillin Improve the Drug Susceptibility against Methicillin-Resistant Staphylococcus aureus

2020 ◽  
Vol 12 (33) ◽  
pp. 36957-36966 ◽  
Author(s):  
Yue Sun ◽  
Songhang Li ◽  
Yuxin Zhang ◽  
Qirong Li ◽  
Xueping Xie ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Nucleic Acids ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Drug Susceptibility ◽  
Tetrahedral Framework ◽  
Methicillin Resistant

Tetrahedral Framework Nucleic Acids Loaded with Aptamer AS1411 for siRNA Delivery and Gene Silencing in Malignant Melanoma

2021 ◽  
Vol 13 (5) ◽  
pp. 6109-6118 ◽  
Author(s):  
Dexuan Xiao ◽  
Yanjing Li ◽  
Taoran Tian ◽  
Tianxu Zhang ◽  
Sirong Shi ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Nucleic Acids ◽  
Gene Silencing ◽  
Sirna Delivery ◽  
Tetrahedral Framework

The Application of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields

2021 ◽  
Vol 16 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Xiaolin Zhang ◽  
Nanxin Liu ◽  
Mi Zhou ◽  
Songhang Li ◽  
Xiaoxiao Cai
Keyword(s):  
Nucleic Acids ◽  
Drug Transport ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Cellular Membrane ◽  
High Yield ◽  
Tetrahedral Framework ◽  
Convenient Synthesis ◽  
Dna Tetrahedron ◽  
Pass Through

In recent years, tetrahedral Framework Nucleic Acids(tFNAs) have become a hot topic in the field of DNA nanostructures because of their stable structures, nanoscale size, superior mechanical properties and convenient synthesis with high yield. tFNAs are considered promising drug delivery carriers because they can pass through the cellular membrane without any help and they have a good biocompatibility and biodegradability. Besides, they have rich modification sites, they can be modified by kinds of functional groups. The functionalization molecules can be modified on the vertexes, embedded between the double-stranded DNA of the tetrahedron edges, hanged on the edges, or encapsulated in the cage-like structure of the tetrahedron. The structure of tetrahedron can also be intelligently controlled through smart design, such as integrating DNA hairpin loop structure onto the edges. Nowadays, DNA tetrahedron will have a broader development prospect in the application of drug transport carriers and intelligent drug carriers. Therefore, DNA material is a new carrier material with great advantages and has a very broad application prospect in the construction of an intelligent drug transport system.

Antioxidative and Angiogenesis-Promoting Effects of Tetrahedral Framework Nucleic Acids in Diabetic Wound Healing with Activation of the Akt/Nrf2/HO-1 Pathway

2020 ◽  
Vol 12 (10) ◽  
pp. 11397-11408 ◽  
Author(s):  
Shiyu Lin ◽  
Qi Zhang ◽  
Songhang Li ◽  
Tao Zhang ◽  
Lang Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nucleic Acids ◽  
Diabetic Wound ◽  
Tetrahedral Framework ◽  
Diabetic Wound Healing
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