PEGylated Protamine-Based Adsorbing Improves the Biological Properties and Stability of Tetrahedral Framework Nucleic Acids

2019 ◽  
Vol 11 (31) ◽  
pp. 27588-27597 ◽  
Author(s):  
Yichen Ge ◽  
Taoran Tian ◽  
Xiaoru Shao ◽  
Shiyu Lin ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Biological Properties ◽  
Tetrahedral Framework

scholarly journals Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

2021 ◽  
Author(s):  
Mei Zhang ◽  
Xiaolin Zhang ◽  
Taoran Tian ◽  
Qi Zhang ◽  
Yuting Wen ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Gouty Arthritis ◽  
Inflammatory Activity ◽  
Tetrahedral Framework ◽  
Acute Gouty Arthritis ◽  
Anti Inflammatory

Tetrahedral framework nucleic acids regulate osteogenic differentiation potential of osteoporotic adipose-derived stem cells

2021 ◽  
Author(s):  
Tianyu Chen ◽  
Dexuan Xiao ◽  
Yanjing Li ◽  
Sirong Shi ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nucleic Acids ◽  
Osteogenic Differentiation ◽  
Adipose Derived Stem Cells ◽  
Differentiation Potential ◽  
Tetrahedral Framework

The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields

2021 ◽  
pp. 137-166
Author(s):  
Xiaolin Zhang ◽  
Yunfeng Lin
Keyword(s):  
Nucleic Acids ◽  
Drug Carrier ◽  
Tetrahedral Framework

Hydroxyproline-Based DNA Mimics: A Review on Synthesis and Properties

2006 ◽  
Vol 71 (7) ◽  
pp. 929-955 ◽  
Author(s):  
Vladimir A. Efimov ◽  
Oksana G. Chakhmakhcheva
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Phosphonic Acid ◽  
Peptide Nucleic Acids ◽  
Biological Properties ◽  
High Potential ◽  
Physicochemical And Biological Properties

With the aim to improve physicochemical and biological properties of natural oligonucleotides, many types of DNA analogues and mimics are designed on the basis of hydroxyproline and its derivatives, and their properties are evaluated. Among them, two types of DNA mimics representing hetero-oligomers constructed from alternating monomers of phosphono peptide nucleic acids and monomers on the base of trans-1-acetyl-4-hydroxy-L-proline (HypNA-pPNAs) and oligomers constructed from monomers containing (2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-phosphonic acid backbone (pHypNAs) are of particular interest. In a set of in vitro and in vivo assays, it was shown that HypNA-pPNAs and pHypNAs demonstrated a high potential for the use in nucleic acid based diagnostics, isolation of nucleic acids and antisense experiments. A review with 53 references.

ChemInform Abstract: Synthesis of Benzene-Glycol Nucleic Acids and Their Biophysical and Biological Properties.

ChemInform ◽  
2016 ◽  
Vol 47 (40) ◽  
Author(s):  
Nazuki Niwa ◽  
Keisuke Ueda ◽  
Yoshihito Ueno
Keyword(s):  
Nucleic Acids ◽  
Biological Properties

scholarly journals Sticky problems: extraction of nucleic acids from molluscs

2021 ◽  
Vol 376 (1825) ◽  
Author(s):  
Coen M. Adema
Keyword(s):  
Nucleic Acids ◽  
Dna Extraction ◽  
Extraction Methods ◽  
Biological Properties ◽  
Alternative Methods ◽  
28S Rrna ◽  
Future Directions ◽  
Dna And Rna ◽  
Standard Quality ◽  
Dna Extraction Methods

Traditional molecular methods and omics-techniques across molluscan taxonomy increasingly inform biology of Mollusca. Recovery of DNA and RNA for such studies is challenged by common biological properties of the highly diverse molluscs. Molluscan biomineralization, adhesive structures and mucus involve polyphenolic proteins and mucopolysaccharides that hinder DNA extraction or copurify to inhibit enzyme-catalysed molecular procedures. DNA extraction methods that employ the detergent hexadecyltrimethylammoniumbromide (CTAB) to remove these contaminants importantly facilitate molecular-level study of molluscs. Molluscan pigments may stain DNA samples and interfere with spectrophotometry, necessitating gel electrophoresis or fluorometry for accurate quantification. RNA can reliably be extracted but the ‘hidden break’ in 28S rRNA of molluscs (like most protostomes) causes 18S and 28S rRNA fragments to co-migrate electrophoretically. This challenges the standard quality control based on the ratio of 18S and 28S rRNA, developed for deuterostome animals. High-AT content in molluscan rRNA prevents the effective purification of polyadenylated mRNA. Awareness of these matters aids the continuous expansion of molecular malacology, enabling work also with museum specimens and next-generation sequencing, with the latter imposing unprecedented demands on DNA quality. Alternative methods to extract nucleic acids from molluscs are available from literature and, importantly, from communications with others who study the molecular biology of molluscs. This article is part of the Theo Murphy meeting issue ‘Molluscan genomics: broad insights and future directions for a neglected phylum’.

scholarly journals MicroRNA‐214‐3p modified tetrahedral framework nucleic acids target survivin to induce tumour cell apoptosis

2019 ◽  
Vol 53 (1) ◽  
Author(s):  
Songhang Li ◽  
Yue Sun ◽  
Taoran Tian ◽  
Xin Qin ◽  
Shiyu Lin ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Tumour Cell ◽  
Cell Apoptosis ◽  
Tetrahedral Framework

Biological Effect of Differently Sized Tetrahedral Framework Nucleic Acids: Endocytosis, Proliferation, Migration, and Biodistribution

2021 ◽  
Author(s):  
Sirong Shi ◽  
Yanjing Li ◽  
Tao Zhang ◽  
Dexuan Xiao ◽  
Taoran Tian ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Biological Effect ◽  
Tetrahedral Framework

Halogenated Nucleic Acids: Biochemical and Biological Properties of Fluorinated Polynucleotides

1985 ◽  
pp. 125-138 ◽  
Author(s):  
J. L. Alderfer ◽  
R. E. Loomis ◽  
S. D. Soni ◽  
M. Sharma ◽  
R. Bernacki ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Biological Properties

Tetrahedral Framework Nucleic Acids Loading Ampicillin Improve the Drug Susceptibility against Methicillin-Resistant Staphylococcus aureus

2020 ◽  
Vol 12 (33) ◽  
pp. 36957-36966 ◽  
Author(s):  
Yue Sun ◽  
Songhang Li ◽  
Yuxin Zhang ◽  
Qirong Li ◽  
Xueping Xie ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Nucleic Acids ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Drug Susceptibility ◽  
Tetrahedral Framework ◽  
Methicillin Resistant
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