scholarly journals MicroRNA‐214‐3p modified tetrahedral framework nucleic acids target survivin to induce tumour cell apoptosis

2019 ◽  
Vol 53 (1) ◽  
Author(s):  
Songhang Li ◽  
Yue Sun ◽  
Taoran Tian ◽  
Xin Qin ◽  
Shiyu Lin ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Tumour Cell ◽  
Cell Apoptosis ◽  
Tetrahedral Framework

scholarly journals Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

2021 ◽  
Author(s):  
Mei Zhang ◽  
Xiaolin Zhang ◽  
Taoran Tian ◽  
Qi Zhang ◽  
Yuting Wen ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Gouty Arthritis ◽  
Inflammatory Activity ◽  
Tetrahedral Framework ◽  
Acute Gouty Arthritis ◽  
Anti Inflammatory

Tetrahedral framework nucleic acids regulate osteogenic differentiation potential of osteoporotic adipose-derived stem cells

2021 ◽  
Author(s):  
Tianyu Chen ◽  
Dexuan Xiao ◽  
Yanjing Li ◽  
Sirong Shi ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nucleic Acids ◽  
Osteogenic Differentiation ◽  
Adipose Derived Stem Cells ◽  
Differentiation Potential ◽  
Tetrahedral Framework

The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields

2021 ◽  
pp. 137-166
Author(s):  
Xiaolin Zhang ◽  
Yunfeng Lin
Keyword(s):  
Nucleic Acids ◽  
Drug Carrier ◽  
Tetrahedral Framework

PEGylated Protamine-Based Adsorbing Improves the Biological Properties and Stability of Tetrahedral Framework Nucleic Acids

2019 ◽  
Vol 11 (31) ◽  
pp. 27588-27597 ◽  
Author(s):  
Yichen Ge ◽  
Taoran Tian ◽  
Xiaoru Shao ◽  
Shiyu Lin ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Biological Properties ◽  
Tetrahedral Framework

scholarly journals Role of peroxide and superoxide anion during tumour cell apoptosis

FEBS Letters ◽  
1997 ◽  
Vol 404 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Adrienne Gorman ◽  
Adrian McGowan ◽  
Thomas G. Cotter
Keyword(s):  
Tumour Cell ◽  
Cell Apoptosis ◽  
Superoxide Anion

scholarly journals Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1‐CX3CR1 dependent manner and induce tumour cell apoptosis

2020 ◽  
Vol 14 (10) ◽  
pp. 2546-2559
Author(s):  
Shuo Miao ◽  
Meng Lu ◽  
Yue Liu ◽  
Dan Shu ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumour Cell ◽  
Cell Apoptosis ◽  
Dependent Manner

scholarly journals An apoptosis-driven ‘onco-regenerative niche’: roles of tumour-associated macrophages and extracellular vesicles

2017 ◽  
Vol 373 (1737) ◽  
pp. 20170003 ◽  
Author(s):  
Christopher D. Gregory ◽  
Margaret Paterson
Keyword(s):  
Extracellular Vesicles ◽  
Tumour Cell ◽  
Cell Apoptosis ◽  
Tissue Repair ◽  
B Cell Lymphoma ◽  
Cell Loss ◽  
Endothelial Activation ◽  
Tumour Microenvironment ◽  
Malignant Tumours ◽  
Tissue Repair And Regeneration

The cell-death programme, apoptosis, is well established as a tumour suppressor mechanism. Paradoxically, high levels of apoptosis in tumours are closely coupled with poor prognosis. Indeed, where it has been studied, cell loss is a striking feature of high-grade cancers, illustrating the importance of considering malignant disease as an imbalance between cell gain and cell loss that favours cell gain rather than as a unidirectional disorder of cell gain alone. In addition to orchestrating cell loss, apoptosis can signal regenerative responses—for example compensatory proliferation—in neighbouring cells. Accumulating evidence suggests that normal tissue repair and regenerative processes are hijacked in the malignant tissue microenvironment such that cancer may be likened to a ‘wound that fails to stop repairing’. We have proposed that a critical requirement for the successful growth, progression and re-growth of malignant tumours is a complex milieu, conceptually termed the ‘onco-regenerative niche’, which is composed, in addition to transformed neoplastic cells, of a network of normal cells and factors activated as if in tissue repair and regeneration. Our work is based around the hypothesis that tumour cell apoptosis, macrophage activation and endothelial activation are key, interlinked elements of the onco-regenerative niche and that apoptotic tumour cell–derived extracellular vesicles provide critical intercellular communication vehicles of the niche. In aggressive B-cell lymphoma, tumour cell apoptosis promotes both angiogenesis and the accumulation of pro-tumour macrophages in the lymphoma microenvironment. Furthermore, apoptotic lymphoma-derived extracellular vesicles have potent pro-tumour potential. These findings have important implications for the roles of apoptosis in regulation of malignant diseases and for the efficacy of apoptosis-inducing anti-cancer therapies. This article is part of the discussion meeting issue ‘Extracellular vesicles and the tumour microenvironment’.

Murine hypodense eosinophils induce tumour cell apoptosis by a granzyme B-dependent mechanism

2001 ◽  
Vol 50 (6) ◽  
pp. 293-299 ◽  
Author(s):  
Darren James Costain ◽  
Ashim K. Guha ◽  
Robert Stefan Liwski ◽  
Timothy D. G. Lee
Keyword(s):  
Tumour Cell ◽  
Cell Apoptosis ◽  
Granzyme B ◽  
Dependent Mechanism

Biological Effect of Differently Sized Tetrahedral Framework Nucleic Acids: Endocytosis, Proliferation, Migration, and Biodistribution

2021 ◽  
Author(s):  
Sirong Shi ◽  
Yanjing Li ◽  
Tao Zhang ◽  
Dexuan Xiao ◽  
Taoran Tian ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Biological Effect ◽  
Tetrahedral Framework
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