Mussel-Inspired Durable Antimicrobial Contact Lenses: The Role of Covalent and Noncovalent Attachment of Antimicrobials

Objective: The purpose of our research is to emphasize the role of underestimated predisposing conditions for microbial keratitis in contact lens users, to draw attention to the complications of wearing contact lenses without ophthalmic examination, and to offer a short questionnaire for fast and easy estimation of the risk factors for bacterial keratitis. Methods: A series of 23 cases of healthy young individuals, treated for bacterial keratitis, provoked а research on the predisposing factors for its development. Results: 55% of the patients had started to wear contact lenses without specific examination. 75% had made mistakes in the hygiene and storage of the lenses. We identified risk factors for development of bacterial keratitis in all cases. Conclusions: A thorough anamnesis and ophthalmic examination are crucial in decision making about contact lens wearing because they could reveal some of the predisposing conditions for the occurrence of ocular complications. The usage of contact lenses without a prescription poses health risks and could have a negative impact on the social and healthcare system.

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The Specific Role of Contact Lenses in Sensorimotor Anomalies

American Orthoptic Journal ◽

10.1080/0065955x.1966.11981518 ◽

1966 ◽

Vol 16 (1) ◽

pp. 30-43

Author(s):

John S. Hermann

Keyword(s):

Contact Lenses ◽

Specific Role

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(CL-147)MANAGING A RARE GENETIC DISORDER: THE ROLE OF GAS PERMEABLE SCLERAL CONTACT LENSES

Optometry and Vision Science ◽

10.1097/00006324-200012001-00276 ◽

2000 ◽

Vol 77 (SUPPLEMENT) ◽

pp. 169

Author(s):

George W. Meers

Keyword(s):

Contact Lenses ◽

Genetic Disorder ◽

Rare Genetic Disorder

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Role of Rigid Gas-Permeable Scleral Contact Lenses in the Management of Advanced Atopic Keratoconjunctivitis

Cornea ◽

10.1097/ico.0b013e3181245172 ◽

2007 ◽

Vol 26 (9) ◽

pp. 1032-1034 ◽

Cited By ~ 18

Author(s):

Ron Margolis ◽

Vishakha Thakrar ◽

Victor L Perez

Keyword(s):

Contact Lenses ◽

Atopic Keratoconjunctivitis

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The role of multi-purpose solutions in prevention and removal of lipid depositions on contact lenses

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2014.07.003 ◽

2014 ◽

Vol 37 (6) ◽

pp. 405-414 ◽

Cited By ~ 5

Author(s):

Ngai Keung Tam ◽

William G. Pitt ◽

Krystian X. Perez ◽

Erika Handly ◽

Andrew A. Glenn ◽

...

Keyword(s):

Contact Lenses

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Human IgA inhibits adherence ofAcanthamoeba polyphagato epithelial cells and contact lenses

Canadian Journal of Microbiology ◽

10.1139/w04-057 ◽

2004 ◽

Vol 50 (9) ◽

pp. 711-718 ◽

Cited By ~ 8

Author(s):

Rafael Campos-Rodríguez ◽

Gabriela Oliver-Aguillón ◽

Luz M Vega-Pérez ◽

Adriana Jarillo-Luna ◽

Dolores Hernández-Martínez ◽

...

Keyword(s):

Contact Lenses ◽

Mdck Cells ◽

Secretory Iga ◽

Acanthamoeba Polyphaga ◽

Madin Darby Canine Kidney ◽

Corneal Epithelial ◽

Human Colostrum ◽

Iga Antibodies ◽

Darby Canine Kidney

Specific anti-Acanthamoeba IgA antibodies have been detected in the serum and tears of patients and healthy individuals. However, the role of human secretory IgA antibodies in inhibiting the adherence of Acanthamoeba had not been previously investigated. Therefore, the purpose of this study was to purify secretory IgA from human colostrum and analyze its effect on the adherence of Acanthamoeba trophozoites to contact lenses and Madin–Darby canine kidney (MDCK) cells. IgA antibodies to Acanthamoeba polyphaga in colostrum of healthy women as well as in saliva and serum of healthy subjects were analyzed by ELISA and Western blot analysis. In serum, saliva, and colostrum, we detected IgA antibodies that recognized several antigens of A. polyphaga. In addition, colostrum and IgA antibodies purified from it inhibited adherence of A. polyphaga trophozoites to contact lenses and MDCK cells. These results suggest that IgA antibodies may participate in the resistance to the amoebic infection, probably by inhibiting the adherence of the trophozoites to contact lenses and corneal epithelial cells.Key words: Acanthamoeba polyphaga, free-living amoebas, colostrum, IgA.

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Investigation of Lubrication Characteristics for a Soft Contact Lens

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.823.105 ◽

2019 ◽

Vol 823 ◽

pp. 105-109

Author(s):

Hung Jung Tsai ◽

Jeng Haur Horng ◽

Chung Ming Tan

Keyword(s):

Contact Lens ◽

Contact Lenses ◽

Hydrodynamic Lubrication ◽

Tear Film ◽

Hydrodynamic Pressure ◽

Slider Bearing ◽

Soft Contact ◽

Soft Contact Lens ◽

Lubrication Characteristics

It is popular to wear the contact lens nowadays. Also, the output value of the contact lens is estimated more than 4 billion NT dollar every year. Because the phenomena of the contact lenses are very complicated, the relevant mechanisms are not well understood. Thus, the security of contact lens needs to be further investigated. In the lubricated mechanism of the contact lens, there is a layer of tear between the contact lens and cornea. The contact lens’ behavior is akin to that of a slider bearing. The lens represents the slider, the eye plays the role of the stationary pad, and the tear film is the lubricant. Hence, hydrodynamics and contact mechanisms of a contact lens are quite a fascinating subject that is relevant to the science of tribology. In the paper, the lubrication mechanisms include the partial hydrodynamic lubrication (contact lens roughness), contact mechanics and Newtonian fluid mechanics have been established. The parameters of roughness, flow factor, tear film geometry, and hydrodynamic pressure distribution are discussed. The developed technology increases the safety of contact lens.

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