The role of bifocal and contact lenses in myopia control

Background: Many epidemiological and experimental studies have established that myopia is caused by a complex interaction between common genetic and environmental factors. The objective of this study was to describe and compare the allelic and genotypic frequencies of the rs524952 (GJD2), rs8000973 (ZIC2), rs1881492 (CHRNG), rs1656404 (PRSS56), rs235770 (BMP2), and rs7744813 (KCNQ5) SNPs (single-nucleotide polymorphism) between responder and nonresponder patients who had undergone a two-year treatment with lenses for myopia control. Method: Twenty-eight participants from the MiSight Assessment Study Spain (MASS), who had received treatment for myopia control for two years with MiSight contact lenses, were examined. The criteria for better/worse treatment response was the change in the axial length (< / ≥ 0.22 mm two years after the treatment). The clinical procedure consisted of the extraction of a saliva sample, and the participants also underwent an optometric examination. Genetic data were analyzed using SNPStats software (Catalan Institute of Oncology, Barcelona, Spain), and statistical analysis was performed using SPSS v.25 (SPSS Inc., Chicago, IL, USA). Demographic variables were analyzed using the Student’s t-test. Results: The T allele, the one with the lowest frequency, of the “rs235770” SNP was associated with a better treatment response [AL/CR (axial length/corneal radius): OR = 3.37; CI = 1.079–10.886; SE (spherical equivalent): OR = 1.26; CI: = 0.519–57.169; p = 0.019). By performing haplotype analysis, significant differences were found between the rs235770…rs1881492 and rs235770–rs1656404 polymorphisms. The latter presented a strong linkage disequilibrium with each other (r2 ≥ 0.54). Conclusion: The result of lens therapies for myopia control could vary depending on genetic variants. Studies with a larger sample are needed to confirm the results presented in this pilot study.

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Myopia Control with Combination Low-Dose Atropine and Peripheral Defocus Soft Contact Lenses: A Case Series

Case Reports in Ophthalmology ◽

10.1159/000515568 ◽

2021 ◽

pp. 548-554

Author(s):

Nir Erdinest ◽

Naomi London ◽

Nadav Levinger ◽

Yair Morad

Keyword(s):

Low Dose ◽

Contact Lenses ◽

Case Series ◽

Concentric Circle ◽

Retrospective Case ◽

Soft Contact ◽

Myopia Progression ◽

Soft Contact Lenses ◽

Center Distance ◽

Myopia Control

The goal of this retrospective case series is to demonstrate the effectivity of combination low-dose atropine therapy with peripheral defocus, double concentric circle design with a center distance soft contact lenses at controlling myopia progression over 1 year of treatment. Included in this series are 3 female children aged 8–10 years with progressing myopia averaging −4.37 ± 0.88 D at the beginning of treatment. Their average annual myopic progression during the 3 years prior to therapy was 1.12 ± 0.75 D. They had not attempted any myopia control treatments prior to this therapy. The children were treated with a combination of 0.01% atropine therapy with spherical peripheral defocus daily replacement soft lenses MiSight<sup>®</sup> 1 day (Cooper Vision, Phoenix, AZ, USA). They underwent cycloplegic refraction, and a slit-lamp evaluation every 6 months which confirmed no adverse reactions or staining was present. Each of the 3 children exhibited an average of 0.25 ± 0.25 D of myopia progression at the end of 1 year of treatment. To the best of the authors’ knowledge, this is the first published study exhibiting that combining low-dose atropine and peripheral defocus soft contact lenses is effective at controlling children’s moderate to severe myopia progression during 1 year of therapy.

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Bifocal soft contact lenses as a possible myopia control treatment: a case report involving identical twins

Clinical and Experimental Optometry ◽

10.1111/j.1444-0938.2007.00230.x ◽

2008 ◽

Vol 91 (4) ◽

pp. 394-399 ◽

Cited By ~ 49

Author(s):

Thomas A Aller ◽

Christine Wildsoet

Keyword(s):

Case Report ◽

Contact Lenses ◽

Identical Twins ◽

Control Treatment ◽

Soft Contact ◽

Soft Contact Lenses ◽

Myopia Control

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Results of a two-year clinical study of myopia control with bifocal defocus-inducing soft contact lenses

Vestnik oftal mologii ◽

10.17116/oftalma20211370315 ◽

2021 ◽

Vol 137 (3) ◽

pp. 5

Author(s):

S.E. Avetisov ◽

A.V. Myagkov ◽

A.V. Egorova ◽

Z.N. Poskrebysheva ◽

O.A. Zhabina

Keyword(s):

Clinical Study ◽

Contact Lenses ◽

Soft Contact ◽

Soft Contact Lenses ◽

Myopia Control

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Underestimated risks for bacterial keratitis in contact lens usage

ROMANIAN BIOTECHNOLOGICAL LETTERS ◽

10.25083/rbl/26.3/2626-2630 ◽

2021 ◽

Vol 26 (3) ◽

pp. 2626-2630

Author(s):

EVELINA MILCHEVA MARINOVA ◽

◽

DIMITAR STOIMENOV DABOV ◽

YANI TODOROV ZDRAVKOV ◽

EMILIA KRASIMIROVA NASEVA ◽

...

Keyword(s):

Risk Factors ◽

Contact Lens ◽

Contact Lenses ◽

Negative Impact ◽

Bacterial Keratitis ◽

Ophthalmic Examination ◽

The Social ◽

And Storage ◽

Predisposing Conditions

Objective: The purpose of our research is to emphasize the role of underestimated predisposing conditions for microbial keratitis in contact lens users, to draw attention to the complications of wearing contact lenses without ophthalmic examination, and to offer a short questionnaire for fast and easy estimation of the risk factors for bacterial keratitis. Methods: A series of 23 cases of healthy young individuals, treated for bacterial keratitis, provoked а research on the predisposing factors for its development. Results: 55% of the patients had started to wear contact lenses without specific examination. 75% had made mistakes in the hygiene and storage of the lenses. We identified risk factors for development of bacterial keratitis in all cases. Conclusions: A thorough anamnesis and ophthalmic examination are crucial in decision making about contact lens wearing because they could reveal some of the predisposing conditions for the occurrence of ocular complications. The usage of contact lenses without a prescription poses health risks and could have a negative impact on the social and healthcare system.

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