Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model

2018 ◽  
Vol 5 (2) ◽  
pp. 281-291 ◽  
Author(s):  
Daniel L. Clemens ◽  
Bai-Yu Lee ◽  
Sheba Plamthottam ◽  
Michael V. Tullius ◽  
Ruining Wang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Intramuscular Route ◽  
Nanoparticle Formulation ◽  
Route Of Delivery

Comparison of Midazolam and Diazepam by the Intramuscular Route for the Control of Seizures in a Mouse Model of Status Epilepticus

Epilepsia ◽  
1990 ◽  
Vol 31 (3) ◽  
pp. 313-317 ◽  
Author(s):  
Arthur Raines ◽  
Theresa R. Henderson ◽  
Ewart A. Swinyard ◽  
Kenneth L. Dretchen
Keyword(s):  
Status Epilepticus ◽  
Mouse Model ◽  
Intramuscular Route

Properties and effects of a novel liquid crystal nanoparticle formulation of docetaxel in a prostate cancer mouse model

2010 ◽  
Vol 41 (2) ◽  
pp. 369-375 ◽  
Author(s):  
Camilla Cervin ◽  
Martina Tinzl ◽  
Markus Johnsson ◽  
Per-Anders Abrahamsson ◽  
Fredrik Tiberg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Liquid Crystal ◽  
Mouse Model ◽  
Nanoparticle Formulation

scholarly journals A Novel Encochleated Formulation Improves Atovaquone Activity in a Murine Model of Pneumocystis Pneumonia

2020 ◽  
Author(s):  
Melanie T Cushion ◽  
Parag Kumar ◽  
Ruying Lu ◽  
Alan Ashbaugh ◽  
Lilian W Adeojo ◽  
...  
Keyword(s):  
Adverse Events ◽  
Mouse Model ◽  
Murine Model ◽  
Nonlinear Absorption ◽  
Pneumocystis Pneumonia ◽  
Treatment And Prevention ◽  
Nanoparticle Formulation ◽  
Better Than

Abstract Although atovaquone is effective in treating and preventing Pneumocystis pneumonia (PCP), it’s use is limited by nonlinear absorption and adverse events. The current study was undertaken to examine the activity of encochleated atovaquone (eATQ), a novel lipid-crystal nanoparticle formulation, in a mouse model of PCP. eATQ 100 to 200 mg was superior to commercially available atovaquone at 14 days in decreasing total Pneumocystis nuclei and asci. eATQ plus anidulafungin reduced nuclei significantly better than commercial atovaquone plus anidulafungin. eATQ is a novel formulation of atovaquone that warrants further evaluation for treatment and prevention of PCP.

Regenerating myofibers in tibialis anterior muscles of young ‘MDX’ mice

1987 ◽  
Vol 45 ◽  
pp. 726-727
Author(s):  
H. D. Geissinge ◽  
L.D. Rhodes
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Tibialis Anterior ◽  
Physiological Activity ◽  
Mdx Mice ◽  
Mode Of Inheritance

A recently discovered mouse model (‘mdx’) for muscular dystrophy in man may be of considerable interest, since the disease in ‘mdx’ mice is inherited by the same mode of inheritance (X-linked) as the human Duchenne (DMD) muscular dystrophy. Unlike DMD, which results in a situation in which the continual muscle destruction cannot keep up with abortive regenerative attempts of the musculature, and the sufferers of the disease die early, the disease in ‘mdx’ mice appears to be transient, and the mice do not die as a result of it. In fact, it has been reported that the severely damaged Tibialis anterior (TA) muscles of ‘mdx’ mice seem to display exceptionally good regenerative powers at 4-6 weeks, so much so, that these muscles are able to regenerate spontaneously up to their previous levels of physiological activity.

Mouse model of gastric infection with cytotoxin-expressing strain of Helicobacter pylori in studying of pathogenesis of chronic gastric ulcer

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S178-S184 ◽  
Author(s):  
PETER KONTUREK ◽  
TOMASZ BRZOZOWSKI ◽  
STANISLAW KONTUREK ◽  
ELZBIETA KARCZEWSKA ◽  
ROBERT PAJDO ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Mouse Model ◽  
Chronic Gastric Ulcer
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