Efficient Near-Infrared Photosensitizer with Aggregation-Induced Emission for Imaging-Guided Photodynamic Therapy in Multiple Xenograft Tumor Models

ACS Nano ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 854-866 ◽  
Author(s):  
Jun Dai ◽  
Yinghao Li ◽  
Zi Long ◽  
Ruming Jiang ◽  
Zeyan Zhuang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Xenograft Tumor ◽  
Tumor Models ◽  
Aggregation Induced Emission

Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential

ACS Nano ◽  
2018 ◽  
Vol 12 (8) ◽  
pp. 8145-8159 ◽  
Author(s):  
Zheng Zheng ◽  
Tianfu Zhang ◽  
Haixiang Liu ◽  
Yuncong Chen ◽  
Ryan T. K. Kwok ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Photon Absorption ◽  
Aggregation Induced Emission ◽  
Two Photon Absorption ◽  
Two Photon

A near-infrared bioprobe with aggregation-induced emission feature for in vitro photodynamic therapy

2021 ◽  
pp. 109521
Author(s):  
Liucheng Mao ◽  
Hongye Huang ◽  
Danning Hu ◽  
Haijun Ma ◽  
Mei Tian ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Emission Feature ◽  
Aggregation Induced Emission

scholarly journals Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shoupeng Cao ◽  
Jingxin Shao ◽  
Hanglong Wu ◽  
Shidong Song ◽  
Maria Teresa De Martino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Radiant Energy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Directed Motion ◽  
Aggregation Induced Emission

AbstractAggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence in an assembled state, have applications in various biomedical fields—including photodynamic therapy. Engineering structure-inherent, AIEgenic nanomaterials with motile properties is, however, still an unexplored frontier in the evolution of this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated with AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by an asymmetric Au nanoshell. The hybrid nanomotors can harness two photon near-infrared radiation, triggering autonomous propulsion and simultaneous phototherapeutic generation of reactive oxygen species. The potential of these nanomotors to be applied in photodynamic therapy is demonstrated in vitro, where near-infrared light directed motion and reactive oxygen species induction synergistically enhance efficacy with a high level of spatial control.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy

2021 ◽  
pp. 2002177
Author(s):  
Hongxin Lin ◽  
Zexi Lin ◽  
Konghua Zheng ◽  
Chenlu Wang ◽  
Lisheng Lin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared

Lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescent imaging

2021 ◽  
Author(s):  
Ruiyuan Liu ◽  
Yuping Zhou ◽  
Di Zhang ◽  
Genghan He ◽  
Chuang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
High Fidelity ◽  
Design And Synthesis ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Design and synthesis of near-infrared (NIR) emissive fluorophore for imaging of organelle and photodynamic therapy has received enormous attention. Hence, NIR emissive fluorophore of high-fidelity lysosome targeting, two-photon fluorescence imaging,...

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