Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential

ACS Nano ◽  
2018 ◽  
Vol 12 (8) ◽  
pp. 8145-8159 ◽  
Author(s):  
Zheng Zheng ◽  
Tianfu Zhang ◽  
Haixiang Liu ◽  
Yuncong Chen ◽  
Ryan T. K. Kwok ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Photon Absorption ◽  
Aggregation Induced Emission ◽  
Two Photon Absorption ◽  
Two Photon

scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

scholarly journals Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy

2018 ◽  
Vol 115 (22) ◽  
pp. 5664-5669 ◽  
Author(s):  
Zhixuan Zhou ◽  
Jiangping Liu ◽  
Thomas W. Rees ◽  
Heng Wang ◽  
Xiaopeng Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Photon Absorption ◽  
In Vivo Studies ◽  
Target Tissue ◽  
Noninvasive Treatment ◽  
Two Photon Absorption ◽  
Two Photon

As an effective and noninvasive treatment of various diseases, photodynamic therapy (PTD) relies on the combination of light, a photosensitizer, and oxygen to generate cytotoxic reactive oxygen species that can damage malignant tissue. Much attention has been paid to covalent modifications of the photosensitizers to improve their photophysical properties and to optimize the pathway of the photosensitizers interacting with cells within the target tissue. Herein we report the design and synthesis of a supramolecular heterometallic Ru–Pt metallacycle via coordination-driven self-assembly. While inheriting the excellent photostability and two-photon absorption characteristics of the Ru(II) polypyridyl precursor, the metallacycle also exhibits red-shifted luminescence to the near-infrared region, a larger two-photon absorption cross-section, and higher singlet oxygen generation efficiency, making it an excellent candidate as a photosensitizer for PTD. Cellular studies reveal that the metallacycle selectively accumulates in mitochondria and nuclei upon internalization. As a result, singlet oxygen generated by photoexcitation of the metallacycle can efficiently trigger cell death via the simultaneous damage to mitochondrial function and intranuclear DNA. In vivo studies on tumor-bearing mice show that the metallacycle can efficiently inhibit tumor growth under a low light dose with minimal side effects. The supramolecular approach presented in this work provides a paradigm for the development of PDT agents with high efficacy.

Two-photon absorption spectra of a near-infrared 2-azaazulene polymethine dye: solvation and ground-state symmetry breaking

2013 ◽  
Vol 15 (20) ◽  
pp. 7666 ◽  
Author(s):  
Honghua Hu ◽  
Olga V. Przhonska ◽  
Francesca Terenziani ◽  
Anna Painelli ◽  
Dmitry Fishman ◽  
...  
Keyword(s):  
Symmetry Breaking ◽  
Absorption Spectra ◽  
Ground State ◽  
Near Infrared ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Polymethine Dye

Substituent effects on the aggregation-induced emission and two-photon absorption properties of triphenylamine–dibenzo[a,c]phenazine adducts

2017 ◽  
Vol 1 (7) ◽  
pp. 1396-1405 ◽  
Author(s):  
Ji Yang ◽  
Yuting Gao ◽  
Tao Jiang ◽  
Wen Liu ◽  
Chenchen Liu ◽  
...  
Keyword(s):  
Substituent Effects ◽  
Photon Absorption ◽  
Absorption Properties ◽  
Aggregation Induced Emission ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Combined Features

Non-substituted and alkyl-substituted triphenylamine–dibenzo[a,c]phenazine adducts (Q1–Q3) showed the combined features of ICT plus AEE, while the alkoxy-substituted Q4–Q5 exhibited obvious AIE effects.

scholarly journals Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation

2021 ◽  
Author(s):  
WEN-SHUO KUO ◽  
Chia-Yuan Chang ◽  
Ping-Ching Wu ◽  
Jiu-Yao Wang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Chemical Modification ◽  
Near Infrared ◽  
Photon Absorption ◽  
Excitation Wavelength ◽  
Strong Electron ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Abstract BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. ConclusionThe sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.

scholarly journals Polyfluorenylacetylene for near-infrared laser protection: polymer synthesis, optical limiting mechanism and relationship between molecular structure and properties

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53785-53796 ◽  
Author(s):  
Gang Zhao ◽  
Yan Feng ◽  
Shanyi Guang ◽  
Hongyao Xu ◽  
Naibo Lin ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Near Infrared ◽  
Optical Limiting ◽  
High Thermal Stability ◽  
Photon Absorption ◽  
Structure And Properties ◽  
Absorption Mechanism ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Good Solubility

The incorporation of styryl/stilbene–fluorene into polyacetylenes not only endowed the polymers with novel near-infrared optical limiting properties based on a two-photon absorption mechanism but good solubility and high thermal stability.

Syntheses and properties of acetylene-linked bis- and trisporphyrins toward two-photon photodynamic therapy

2007 ◽  
Vol 11 (06) ◽  
pp. 406-417 ◽  
Author(s):  
Yusuke Inaba ◽  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Cross Section ◽  
Sodium Salt ◽  
Absorption Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Photon Irradiation ◽  
Two Photon

Acetylene-bridged bisporphyrins and trisporphyrins having branched bulky bis(carboxylethyl)methyl meso-substituents were synthesized. These compounds showed large effective two-photon absorption cross-section values at 890 nm measured by using a nanosecond Z-scan method. Sodium salt of hydrolyzed trisporphyrins showed broad and red-shifted Q-bands over 900 nm. Two-photon absorption cross-section values of water-soluble dimers in water were similar to, or slightly larger than, those of ester forms evaluated in toluene. Furthermore, the generation of singlet oxygen upon one-photon irradiation for dimers in water was confirmed.

scholarly journals Two-photon excited deep-red and near-infrared emissive organic co-crystals

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu Wang ◽  
Huang Wu ◽  
Penghao Li ◽  
Su Chen ◽  
Leighton O. Jones ◽  
...  
Keyword(s):  
Cross Sections ◽  
Optical Materials ◽  
Near Infrared ◽  
Infrared Emission ◽  
Photon Absorption ◽  
Electromagnetic Spectrum ◽  
Absorption Bands ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Near Infrared Emission

Abstract Two-photon excited near-infrared fluorescence materials have garnered considerable attention because of their superior optical penetration, higher spatial resolution, and lower optical scattering compared with other optical materials. Herein, a convenient and efficient supramolecular approach is used to synthesize a two-photon excited near-infrared emissive co-crystalline material. A naphthalenediimide-based triangular macrocycle and coronene form selectively two co-crystals. The triangle-shaped co-crystal emits deep-red fluorescence, while the quadrangle-shaped co-crystal displays deep-red and near-infrared emission centered on 668 nm, which represents a 162 nm red-shift compared with its precursors. Benefiting from intermolecular charge transfer interactions, the two co-crystals possess higher calculated two-photon absorption cross-sections than those of their individual constituents. Their two-photon absorption bands reach into the NIR-II region of the electromagnetic spectrum. The quadrangle-shaped co-crystal constitutes a unique material that exhibits two-photon absorption and near-infrared emission simultaneously. This co-crystallization strategy holds considerable promise for the future design and synthesis of more advanced optical materials.

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