Methicillin Resistant Staphylococcus aureus (MRSA) and
multidrug-resistant Acinetobacter baumanii are known to cause
delayed healing of infections in both acute and chronic wounds. Plants
are a natural source of novel antimicrobials and many new drugs are
derived from plants, as plants contain phytochemicals that have
antimicrobial activity. Sri Lanka is a tropical country with a wide
variety of plant species, many of which were identified as possessing
medicinal qualities and have been used by traditional medicinal
practitioners in the treatment of various diseases and ailments.
Dressings made of Rhipsalis baccifera and Drymoglossum
piloselloides have been used to treat wounds by Sri Lankan traditional
medicine practitioners. This study determined the antibacterial activity
of aqueous and methanol extracts of R. baccifera and D. piloselloides
against MRSA and Multidrug-resistant A. baumanii. Aqueous and
methanolic extractions of both plants were done by maceration. Their
antibacterial properties were checked against MRSA and A. baumanii
by the well diffusion method. The effectiveness of the extract was
further tested against factors like temperature and storage time.
R. baccifera (aqueous extract) exhibited antimicrobial properties
against MRSA but no activity against A. baumanii. The antibiotic
activity against MRSA was increased after two months of storage at
4°C. D. piloselloides exhibited no antibiotic activity against both
MRSA and A. baumanii. The methanolic extracts did not demonstrate
any antibacterial activity.
Expedient Synthesis of Indolo[2,3-b]quinolines, Chromeno[2,3-b]indoles, and 3-Alkenyl-oxindoles from 3,3′-Diindolylmethanes and Evaluation of Their Antibiotic Activity against Methicillin-Resistant Staphylococcus aureus
