scholarly journals Thiophene Derivatives as New Anticancer Agents and Their Therapeutic Delivery Using Folate Receptor-Targeting Nanocarriers

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 8874-8880 ◽  
Author(s):  
Menghui Zhao ◽  
Yaxin Cui ◽  
Lang Zhao ◽  
Tianyu Zhu ◽  
Robert J. Lee ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Folate Receptor ◽  
Receptor Targeting ◽  
Therapeutic Delivery ◽  
Thiophene Derivatives ◽  
Folate Receptor Targeting

scholarly journals Smart Human-Serum-Albumin-As2O3Nanodrug with Self-Amplified Folate Receptor-Targeting Ability for Chronic Myeloid Leukemia Treatment

2017 ◽  
Vol 129 (36) ◽  
pp. 10985-10989 ◽  
Author(s):  
Yongbo Peng ◽  
Zilong Zhao ◽  
Teng Liu ◽  
Xiong Li ◽  
Xiaoxiao Hu ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Myeloid Leukemia ◽  
Folate Receptor ◽  
Receptor Targeting ◽  
Leukemia Treatment ◽  
Targeting Ability ◽  
Folate Receptor Targeting

scholarly journals Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis

2017 ◽  
Vol Volume 12 ◽  
pp. 6735-6746 ◽  
Author(s):  
Jinlong Zhao ◽  
Menghui Zhao ◽  
Changhui Yu ◽  
Xueyan Zhang ◽  
Jiaxin Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Folate Receptor ◽  
Ph Responsive ◽  
Receptor Targeting ◽  
Folate Receptor Targeting

Radiosynthesis and Preclinical Evaluation of 3′-Aza-2′-[18F]fluorofolic Acid: A Novel PET Radiotracer for Folate Receptor Targeting

2013 ◽  
Vol 24 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Thomas Betzel ◽  
Cristina Müller ◽  
Viola Groehn ◽  
Adrienne Müller ◽  
Josefine Reber ◽  
...  
Keyword(s):  
Folate Receptor ◽  
Receptor Targeting ◽  
Preclinical Evaluation ◽  
Folate Receptor Targeting

scholarly journals Tumor imaging using P866, a high-relaxivity gadolinium chelate designed for folate receptor targeting

2008 ◽  
Vol 60 (6) ◽  
pp. 1337-1346 ◽  
Author(s):  
Claire Corot ◽  
Philippe Robert ◽  
Eric Lancelot ◽  
Philippe Prigent ◽  
Sébastien Ballet ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Folate Receptor ◽  
Receptor Targeting ◽  
Gadolinium Chelate ◽  
High Relaxivity ◽  
Folate Receptor Targeting

Abstract 1929: Antifolates as folate receptor targeting ligands: Design and synthesis of their conjugates with cytotoxic agents

2012 ◽  
Author(s):  
Iontcho Vlahov ◽  
Fei You ◽  
Ryan Dorton ◽  
Elaine Westrick ◽  
Joseph Reddy ◽  
...  
Keyword(s):  
Folate Receptor ◽  
Cytotoxic Agents ◽  
Receptor Targeting ◽  
Design And Synthesis ◽  
Folate Receptor Targeting

scholarly journals Effects of Polyethylene Glycol Spacer Length and Ligand Density on Folate Receptor Targeting of Liposomal Doxorubicin In Vitro

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Kumi Kawano ◽  
Yoshie Maitani
Keyword(s):  
Polyethylene Glycol ◽  
Liposomal Doxorubicin ◽  
Folate Receptor ◽  
In Vitro Cytotoxicity ◽  
Receptor Targeting ◽  
Spacer Length ◽  
Ligand Density ◽  
Molecular Weights ◽  
Folate Receptor Targeting

The folate receptor is an attractive target for selective tumor delivery of liposomal doxorubicin (DXR) because it is abundantly expressed in a large percentage of tumors. This study examined the effect of polyethylene glycol (PEG) spacer length and folate ligand density on the targeting ability of folate-modified liposomes. Liposomes were modified with folate-derivatized PEG-distearoylphosphatidylethanolamine with PEG molecular weights of 2000, 3400, or 5000. The association of DXR-loaded liposomes with KB cells, which overexpress the folate receptor, was evaluated by flow cytometry at various ratios of folate modification. A low ratio of folate modification with a sufficiently long PEG chain showed the highest folate receptor-mediated association with the cells, but did not show the highest in vitro cytotoxicity. DXR release from folate-modified liposomes in endosomes might be different. These findings will be useful for designing folate receptor-targeting carriers.

scholarly journals Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis

Theranostics ◽  
2014 ◽  
Vol 4 (2) ◽  
pp. 142-153 ◽  
Author(s):  
Dehong Hu ◽  
Zonghai Sheng ◽  
Shengtao Fang ◽  
Yanan Wang ◽  
Duyang Gao ◽  
...  
Keyword(s):  
Folate Receptor ◽  
Gold Nanoclusters ◽  
Receptor Targeting ◽  
Enzyme Mimetic ◽  
Folate Receptor Targeting

scholarly journals Correction: Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 17041-17041 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Receptor Targeting ◽  
Anti Cancer ◽  
Folate Receptor Targeting

Correction for ‘Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs’ by Xubo Zhao et al., RSC Adv., 2014, 4, 24232–24239.

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