Biosynthesis of the Calorie-Free Sweetener Precursor ent-Kaurenoic Acid from CO2 Using Engineered Cyanobacteria

2020 ◽  
Vol 9 (11) ◽  
pp. 2979-2985
Author(s):  
Sung Cheon Ko ◽  
Han Min Woo
Keyword(s):  
Kaurenoic Acid

scholarly journals Seasonal Variation of Kaurenoic Acid, a Hypoglycemic Diterpene Present in Wedelia paludosa (Acmela brasiliensis) (Asteraceae)

2004 ◽  
Vol 59 (3-4) ◽  
pp. 229-232 ◽  
Author(s):  
Louisiane Faccio V. Bresciania ◽  
Rosendo Augusto Yunes ◽  
Cristiani Bürger ◽  
Luis Eduardo De Oliveira ◽  
Kauê Leal Bóf ◽  
...  
Keyword(s):  
Seasonal Variation ◽  
Kaurenoic Acid ◽  
Different Seasons ◽  
Hypoglycemic Diterpene

We evaluated the variation of the concentration of kaurenoic acid (1), which is a bioactive diterpene, in leaves, flowers, stems and roots from Wedelia paludosa (Acmela brasiliensis) for different seasons using the HRGC/FID method. The results indicated that the concentration of 1 is higher in the roots and stems during the autumn. The pharmacological results suggested that kaurenoic acid is responsible, at least in part, for the hypoglycemic potential detected in this plant.

Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice

1986 ◽  
Vol 169 (3) ◽  
pp. 93-103 ◽  
Author(s):  
John M. Pezzuto ◽  
N.P. Dhammika Nanayakkara ◽  
Cesar M. Compadre ◽  
Steven M. Swanson ◽  
A.Douglas Kinghorn ◽  
...  
Keyword(s):  
Glutathione S Transferase ◽  
Kaurenoic Acid

Preparative separation and quantitative determination of two kaurenoic acid isomers in root barks of Acanthopanax gracilistylus

2017 ◽  
Vol 15 (8) ◽  
pp. 625-630 ◽  
Author(s):  
Xin-Xin XIE ◽  
Ze-Jing JIANG ◽  
Zhi-Hong CHENG ◽  
Dao-Feng CHEN
Keyword(s):  
Quantitative Determination ◽  
Preparative Separation ◽  
Kaurenoic Acid

Daminozide Enhances Vigor and Steviol Glycoside Yield of Stevia (Stevia rebaudiana Bert.) Propagated in the Temporary Immersion Bioreactor

2022 ◽  
Author(s):  
Rizka Tamania Saptari ◽  
Rizkita Rachmi Esyanti ◽  
Riza Arief Putranto
Keyword(s):  
Stevia Rebaudiana ◽  
Feedback Regulation ◽  
Optimum Concentration ◽  
Temporary Immersion Bioreactor ◽  
Temporary Immersion ◽  
Steviol Glycoside ◽  
Kaurenoic Acid ◽  
Biosynthesis Gene ◽  
Inhibitor Treatment ◽  
Ga Biosynthesis

Abstract Stevia (Stevia rebaudiana Bertoni) contains sweet compound widely used as natural sweetener, steviol glycoside (SG). SG is a diterpenoid secondary metabolite synthesized from ent-kaurenoic acid, the same precursor of Gibberellin (GA). Therefore, in this study, a GA inhibitor, Daminozide (0, 10, 20 ppm) was used to block ent-kaurenoic acid conversion towards GA synthesis in attempt to increase SG content of stevia propagated in Temporary Immersion Bioreactor (TIB). Daminozide in 10 mg/L was observed to be the optimum concentration which increased biomass weight and SG content (stevioside and rebaudioside A) up to 40%. The treatment also increased transcripts accumulation of genes enrolled in SG biosynthesis, such as SrKA13H, SrUGT85C2, and SrUGT76G1, indicating SG pathway become more active due to the inhibition of GA pathway. Furthermore, the inhibition of GA was also indicated by the upregulated expression of GA biosynthesis gene (GA3ox) as the result of feedback regulation, and the downregulated expression of GA catabolism gene (GA2ox2) as the result of feed-forward regulation caused by inhibitor treatment.

Kaurenoic acid and its sodium salt derivative: antibacterial activity againstPorphyromonas gingivalisand their mechanism of action

2018 ◽  
Vol 13 (14) ◽  
pp. 1585-1601 ◽  
Author(s):  
Carlos HG Martins ◽  
Fariza Abrão ◽  
Thaís S Moraes ◽  
Pollyanna F Oliveira ◽  
Denise C Tavares ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Mechanism Of Action ◽  
Sodium Salt ◽  
Kaurenoic Acid

scholarly journals SYNTHESIS AND CHARACTERIZATION OF THREE ORGANOTIN(IV) CARBOXYLATE OF ENT-KAURENOIC ACID: ANTIFUNGAL ACTIVITY AGAINST TRAMETES VERSICOLOR (L.: FR) PILÀT

2019 ◽  
Vol 16 (32) ◽  
pp. 912-918
Author(s):  
P. QUINTERO-RINCÓN ◽  
B. FONTAL-RIVERA ◽  
R. CONTRERAS ◽  
Y. FONSECA ◽  
J. VELÁSQUEZ-GIL
Keyword(s):  
Trametes Versicolor ◽  
Forest Products ◽  
White Rot ◽  
Wood Preservation ◽  
Dilution Method ◽  
Forest Products Industry ◽  
Kaurenoic Acid ◽  
Standing Trees ◽  
Anti Fungal

The forest products industry has a very important role in the development toward a sustainable, biobased society. However, many fungi that deteriorate the main structural components of wood, such as cellulose, hemicellulose and lignin, are able to cause decay in standing trees, leading to significant losses in forest output due to impacts on biomass production. Trametes versicolor (L.: Fr) Pilát is a fungus able to attack the trees by saprotrophic and parasitic life strategies, causing white-rot of wood species, a serious problem for the industry that is focused on wood and its uses. The objectives of the work were the synthesis of organotin(IV) carboxylate of a natural product (ent-kaurenoic acid), characterization of the structures and anti-fungal evaluation against T. versicolor, as a contribution of new alternatives for the wood preservation. The synthesis of organotin(IV) complexes derived from the diterpene tetracyclic ent-kaur-16-en-19-oic acid (ent-kaurenoic acid, KA) gave three new complexes potentially active against T. versicolor. The complexes were characterized by FTIR and NMR spectroscopy. The biological activity was evaluated by a gel dilution method with superficialplate inoculation, using 60 and 120 μg/mL concentration, for the KA and the three organotin(IV) complexes. A considerably higher bioactivity was observed to the 120 μg/mL concentration, and for the complex with greater molecular weight.

Ent-Kaurenoic Acid: A Diterpene as Frond Exudate on Ferns of the Genus Notholaena

1983 ◽  
Vol 38 (1-2) ◽  
pp. 146-147 ◽  
Author(s):  
Eckhard Wollenweber ◽  
Dieter Marx ◽  
Jean Favre-Bonvin ◽  
Claude Brassy
Keyword(s):  
Authentic Sample ◽  
Spectroscopic Methods ◽  
Flavonoid Aglycones ◽  
Kaurenoic Acid

The frond exudates of the two gymnogrammoid ferns, Notholaena peninsular is and N. pallens, consist mainly of a diterpene, accompanied by small amounts of flavonoid aglycones. The diterpenes from both sources are shown to be identical. Their structure has been established by spectroscopic methods as (-)-kaur-16-ene-19-oic acid. This result is confirmed by direct comparison with an authentic sample.

Biosynthesis of (−)- ent -kaurenoic acid in Smallanthus sonchifolius and its effect against microbial biofilms

2016 ◽  
Vol 18 ◽  
pp. 162-167 ◽  
Author(s):  
Adriana A. Lopes ◽  
Edieidia S. Pina ◽  
Talita T. Nader ◽  
Fernando B. Da Costa ◽  
Ana Maria S. Pereira ◽  
...  
Keyword(s):  
Smallanthus Sonchifolius ◽  
Microbial Biofilms ◽  
Kaurenoic Acid
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