Episome-Based Gene Expression Modulation Platform in the Model Diatom Phaeodactylum tricornutum

2022 ◽  
Author(s):  
Tessema K. Kassaw ◽  
Andrew J. Paton ◽  
Graham Peers
Keyword(s):  
Gene Expression ◽  
Phaeodactylum Tricornutum ◽  
Expression Modulation

Gene expression modulation is an evolutionary resource of adaptive alterations in the morphogenesis of insect limbs

2012 ◽  
Vol 39 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Yu. E. Vorontsova ◽  
R. O. Cherezov ◽  
O. G. Zatsepina ◽  
M. S. Slezinger ◽  
B. A. Kuzin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Modulation

scholarly journals CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells

2018 ◽  
Vol 13 (10) ◽  
pp. 1700217 ◽  
Author(s):  
Nicolas Marx ◽  
Clemens Grünwald-Gruber ◽  
Nina Bydlinski ◽  
Heena Dhiman ◽  
Ly Ngoc Nguyen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cho Cells ◽  
Expression Modulation ◽  
Epigenetic Editing

scholarly journals A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 796 ◽  
Author(s):  
Andrea Gille ◽  
Bojan Stojnic ◽  
Felix Derwenskus ◽  
Andreas Trautmann ◽  
Ulrike Schmid-Staiger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Weight ◽  
Adipose Tissue ◽  
Food Intake ◽  
Phaeodactylum Tricornutum ◽  
Body Weight Gain ◽  
Acid Oxidation ◽  
Lipid Uptake ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose

Phaeodactylum tricornutum (P. tricornutum) comprise several lipophilic constituents with proposed anti-obesity and anti-diabetic properties. We investigated the effect of an ethanolic P. tricornutum extract (PTE) on energy metabolism in obesity-prone mice fed a high fat diet (HFD). Six- to eight-week-old male C57BL/6J mice were switched to HFD and, at the same time, received orally placebo or PTE (100 mg or 300 mg/kg body weight/day). Body weight, body composition, and food intake were monitored. After 26 days, blood and tissue samples were collected for biochemical, morphological, and gene expression analyses. PTE-supplemented mice accumulated fucoxanthin metabolites in adipose tissues and attained lower body weight gain, body fat content, weight of white adipose tissue (WAT) depots, and inguinal WAT adipocyte size than controls, independent of decreased food intake. PTE supplementation was associated with lower expression of Mest (a marker of fat tissue expandability) in WAT depots, lower gene expression related to lipid uptake and turnover in visceral WAT, increased expression of genes key to fatty acid oxidation and thermogenesis (Cpt1, Ucp1) in subcutaneous WAT, and signs of thermogenic activation including enhanced UCP1 protein in interscapular brown adipose tissue. In conclusion, these data show the potential of PTE to ameliorate HFD-induced obesity in vivo.

scholarly journals Temperature increase prevails over acidification in gene expression modulation of amastigote differentiation in Leishmania infantum

BMC Genomics ◽  
2010 ◽  
Vol 11 (1) ◽  
pp. 31 ◽  
Author(s):  
Pedro J Alcolea ◽  
Ana Alonso ◽  
Manuel J Gomez ◽  
Alicia Sanchez-Gorostiaga ◽  
Mercedes Moreno-Paz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Temperature Increase ◽  
Leishmania Infantum ◽  
Expression Modulation

Gene-expression modulation of TRH, its receptors, and inactivating enzyme, is brain-region specific and depends on the behavioural paradigm

Neuropeptides ◽  
2006 ◽  
Vol 40 (6) ◽  
pp. 438
Author(s):  
P. Joseph-Bravo ◽  
M. Gutiérrez-Mariscal ◽  
A. Aguilar-Valles ◽  
A.I. García-Vázquez ◽  
P. de Gortari
Keyword(s):  
Gene Expression ◽  
Brain Region ◽  
Expression Modulation

scholarly journals Gene expression modulation by paraquat-induced oxidative stress conditions in Paracoccidioides brasiliensis

2013 ◽  
Vol 60 ◽  
pp. 101-109 ◽  
Author(s):  
Marcus Vinícius de Oliveira ◽  
Ana Claudia de Freitas Oliveira ◽  
Cláudio S. Shida ◽  
Regina Costa de Oliveira ◽  
Luiz R. Nunes
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Paracoccidioides Brasiliensis ◽  
Stress Conditions ◽  
Expression Modulation

Sex-dependent dose response of gene expression modulation after ochratoxin A insult in F344 rats

2017 ◽  
Vol 280 ◽  
pp. S88
Author(s):  
Ariane Vettorazzi ◽  
Laura Pastor ◽  
Adela López de Cerain
Keyword(s):  
Gene Expression ◽  
Ochratoxin A ◽  
Dose Response ◽  
Expression Modulation ◽  
F344 Rats
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