Increased Lipid Production in Yarrowia lipolytica from Acetate through Metabolic Engineering and Cosubstrate Fermentation

Author(s):  
Lin Chen ◽  
Wei Yan ◽  
Xiujuan Qian ◽  
Minjiao Chen ◽  
Xiaoyu Zhang ◽  
...  
2020 ◽  
Vol 8 (12) ◽  
pp. 1937
Author(s):  
Young-Kyoung Park ◽  
Jean-Marc Nicaud

Using microorganisms as lipid-production factories holds promise as an alternative method for generating petroleum-based chemicals. The non-conventional yeast Yarrowia lipolytica is an excellent microbial chassis; for example, it can accumulate high levels of lipids and use a broad range of substrates. Furthermore, it is a species for which an array of efficient genetic engineering tools is available. To date, extensive work has been done to metabolically engineer Y. lipolytica to produce usual and unusual lipids. Unusual lipids are scarce in nature but have several useful applications. As a result, they are increasingly becoming the targets of metabolic engineering. Unusual lipids have distinct structures; they can be generated by engineering endogenous lipid synthesis or by introducing heterologous enzymes to alter the functional groups of fatty acids. In this review, we describe current metabolic engineering strategies for improving lipid production and highlight recent researches on unusual lipid production in Y. lipolytica.


GCB Bioenergy ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 670-679 ◽  
Author(s):  
Sang Do Yook ◽  
Jiwon Kim ◽  
Gyeongtack Gong ◽  
Ja Kyong Ko ◽  
Youngsoon Um ◽  
...  

2019 ◽  
Vol 290 ◽  
pp. 10-15 ◽  
Author(s):  
Shuyan Zhang ◽  
Sujit Sadashiv Jagtap ◽  
Anshu Deewan ◽  
Christopher V. Rao

2013 ◽  
Vol 98 (1) ◽  
pp. 251-262 ◽  
Author(s):  
A. Beopoulos ◽  
J. Verbeke ◽  
F. Bordes ◽  
M. Guicherd ◽  
M. Bressy ◽  
...  

2017 ◽  
Vol 184 (4) ◽  
pp. 1332-1346 ◽  
Author(s):  
Mathiazhakan Kuttiraja ◽  
Ayed Dhouha ◽  
Rajeshwar Dayal Tyagi

2020 ◽  
Vol 42 (6) ◽  
pp. 945-956 ◽  
Author(s):  
Xin-Kai Zhang ◽  
Dan-Ni Wang ◽  
Jun Chen ◽  
Zhi-Jie Liu ◽  
Liu-Jing Wei ◽  
...  

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