Linear Polyethyleneimine Grafted to a Hyperbranched Poly(ethylene glycol)-like Core:  A Copolymer for Gene Delivery

2006 ◽  
Vol 17 (1) ◽  
pp. 125-131 ◽  
Author(s):  
Pallab Banerjee ◽  
Ralph Weissleder ◽  
Alexei Bogdanov
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Hyperbranched Poly ◽  
Poly Ethylene

Cationic long-chain hyperbranched poly(ethylene glycol)s with low charge density for gene delivery

2013 ◽  
Vol 4 (2) ◽  
pp. 393-401 ◽  
Author(s):  
Chunlai Tu ◽  
Nan Li ◽  
Lijuan Zhu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Charge Density ◽  
Poly Ethylene Glycol ◽  
Hyperbranched Poly ◽  
Poly Ethylene ◽  
Low Charge ◽  
Long Chain

Hyperbranched Poly(ethylene glycol)s:  A New Class of Ion-Conducting Materials

1996 ◽  
Vol 29 (11) ◽  
pp. 3831-3838 ◽  
Author(s):  
Craig J. Hawker ◽  
Fengkui Chu ◽  
Peter J. Pomery ◽  
David J. T. Hill
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
New Class ◽  
Hyperbranched Poly ◽  
Conducting Materials ◽  
Ion Conducting ◽  
Poly Ethylene

Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly( l -lysine) block copolymers as systemic gene delivery carrier

Biomaterials ◽  
2017 ◽  
Vol 126 ◽  
pp. 31-38 ◽  
Author(s):  
Kaori M. Takeda ◽  
Yuichi Yamasaki ◽  
Anjaneyulu Dirisala ◽  
Sorato Ikeda ◽  
Theofilus A. Tockary ◽  
...  
Keyword(s):  
Shear Stress ◽  
Block Copolymers ◽  
Gene Delivery ◽  
Ethylene Glycol ◽  
Structure And Function ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
And Function ◽  
Systemic Gene Delivery

scholarly journals The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1068 ◽  
Author(s):  
Danijela Zukancic ◽  
Estelle J. A. Suys ◽  
Emily H. Pilkington ◽  
Azizah Algarni ◽  
Hareth Al-Wassiti ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gene Delivery ◽  
Ethylene Glycol ◽  
Lymph Nodes ◽  
Injection Site ◽  
Targeted Delivery ◽  
Lipid Nanoparticles ◽  
Tween 20 ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the liver and typically exhibit off-target transfection at various tissues. Here we report novel lipid nanoparticles (LNPs) that can deliver plasmid DNA (pDNA) to a draining lymph node, thereby significantly enhancing transfection at this target organ, and substantially reducing gene expression at the intramuscular injection site (muscle). In particular, we discovered that LNPs stabilized by 3% Tween 20, a surfactant with a branched poly(ethylene glycol) (PEG) chain linking to a short lipid tail, achieved highly specific transfection at the lymph node. This was in contrast to conventional LNPs stabilized with a linear PEG chain and two saturated lipid tails (PEG-DSPE) that predominately transfected at the injection site (muscle). Interestingly, replacing Tween 20 with Tween 80, which has a longer unsaturated lipid tail, led to a much lower transfection efficiency. Our work demonstrates the importance of PEGylation in selective organ targeting of nanoparticles, provides new insights into the structure–property relationship of LNPs, and offers a novel, simple, and practical PEGylation technology to prepare the next generation of safe and effective vaccines against viruses or tumours.

Alkylimidazolium End-Modified Poly(ethylene glycol) To Form the Mono-ion Complex with Plasmid DNA for in Vivo Gene Delivery

2014 ◽  
Vol 15 (3) ◽  
pp. 997-1001 ◽  
Author(s):  
Shoichiro Asayama ◽  
Atsushi Nohara ◽  
Yoichi Negishi ◽  
Hiroyoshi Kawakami
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Plasmid Dna ◽  
Poly Ethylene Glycol ◽  
In Vivo Gene Delivery ◽  
Poly Ethylene

A Poly(β-Amino Ester) of Spermine and Poly(ethylene Glycol) Diacrylate as a Gene Carrier

2007 ◽  
Vol 342-343 ◽  
pp. 425-428 ◽  
Author(s):  
Dhananjay Jere ◽  
Tae Hee Kim ◽  
Rohidas B. Arote ◽  
Hu Lin Jiang ◽  
Myung Haing Cho ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Water Soluble ◽  
Gene Carrier ◽  
Gene Delivery System ◽  
Poly Ethylene Glycol ◽  
Wide Range ◽  
Poly Ethylene

Vectors are vital aspect of gene delivery system which decides the success of gene therapy. Efficient transfection with minimum or no toxicity, are two principal aims of any gene delivery system. In this our study, we rationally developed biodegradable water soluble poly(ßamino ester) (PAE) based on spermine (SPR) and poly (ethylene glycol) (PEG), by Michael-type addition reaction and further studied for its potential as a gene carrier. Confirmation of synthesized PAE was done by proton NMR spectroscopy. In gel retardation assay, the PAEs have shown good DNA binding ability over wide range of polyplexes. The addition of PEG over SPR resulted in a novel PAE with higher degree of safety and transfection efficiency as compared with polyethylenimine 25K (PEI) when studied in 293T human kidney carcinoma cells.

Folate Receptor-Mediated Gene Delivery Using Folate-Poly(ethylene glycol)-Poly(L-lysine) Conjugate

2005 ◽  
Vol 5 (6) ◽  
pp. 512-519 ◽  
Author(s):  
Kyung Chul Cho ◽  
Sun Hwa Kim ◽  
Ji Hoon Jeong ◽  
Tae Gwan Park
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Folate Receptor ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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