d-Mannose-Modified Iron Oxide Nanoparticles for Stem Cell Labeling

2007 ◽  
Vol 18 (3) ◽  
pp. 635-644 ◽  
Author(s):  
Daniel Horák ◽  
Michal Babič ◽  
Pavla Jendelová ◽  
Vít Herynek ◽  
Miroslava Trchová ◽  
...  
Keyword(s):  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cell Labeling ◽  
Oxide Nanoparticles

scholarly journals Mesenchymal Stem Cells Do Not Lose Direct Labels Including Iron Oxide Nanoparticles and DFO-89Zr Chelates through Secretion of Extracellular Vesicles

Membranes ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 484
Author(s):  
Yue Gao ◽  
Anna Jablonska ◽  
Chengyan Chu ◽  
Piotr Walczak ◽  
Miroslaw Janowski
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Extracellular Vesicles ◽  
Superparamagnetic Iron Oxide ◽  
Cell Labeling ◽  
Oxide Nanoparticles ◽  
Stem Cell Delivery ◽  
Cellular Labeling

Rapidly ageing populations are beset by tissue wear and damage. Stem cell-based regenerative medicine is considered a solution. Years of research point to two important aspects: (1) the use of cellular imaging to achieve sufficient precision of therapeutic intervention, and the fact that (2) many therapeutic actions are executed through extracellular vesicles (EV), released by stem cells. Therefore, there is an urgent need to interrogate cellular labels in the context of EV release. We studied clinically applicable cellular labels: superparamagnetic iron oxide nanoparticles (SPION), and radionuclide detectable by two main imaging modalities: MRI and PET. We have demonstrated effective stem cell labeling using both labels. Then, we obtained EVs from cell cultures and tested for the presence of cellular labels. We did not find either magnetic or radioactive labels in EVs. Therefore, we report that stem cells do not lose labels in released EVs, which indicates the reliability of stem cell magnetic and radioactive labeling, and that there is no interference of labels with EV content. In conclusion, we observed that direct cellular labeling seems to be an attractive approach to monitoring stem cell delivery, and that, importantly, labels neither locate in EVs nor affect their basic properties.

scholarly journals Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking

Theranostics ◽  
2013 ◽  
Vol 3 (8) ◽  
pp. 595-615 ◽  
Author(s):  
Li Li ◽  
Wen Jiang ◽  
Kui Luo ◽  
Hongmei Song ◽  
Fang Lan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Cell Labeling ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Non Invasive

Highly efficient magnetic stem cell labeling with citrate-coated superparamagnetic iron oxide nanoparticles for MRI tracking

Biomaterials ◽  
2012 ◽  
Vol 33 (18) ◽  
pp. 4515-4525 ◽  
Author(s):  
Kristin Andreas ◽  
Radostina Georgieva ◽  
Mechthild Ladwig ◽  
Susanne Mueller ◽  
Michael Notter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Cell Labeling ◽  
Oxide Nanoparticles ◽  
Highly Efficient

Poly(l-lysine)-Modified Iron Oxide Nanoparticles for Stem Cell Labeling

2008 ◽  
Vol 19 (3) ◽  
pp. 740-750 ◽  
Author(s):  
Michal Babič ◽  
Daniel Horák ◽  
Miroslava Trchová ◽  
Pavla Jendelová ◽  
Kateřina Glogarová ◽  
...  
Keyword(s):  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cell Labeling ◽  
Oxide Nanoparticles

scholarly journals Intra-articular tracking of adipose-derived stem cells by chitosan-conjugated iron oxide nanoparticles in a rat osteoarthritis model

RSC Advances ◽  
2019 ◽  
Vol 9 (21) ◽  
pp. 12010-12019 ◽  
Author(s):  
Meihua Xie ◽  
ShuLin Luo ◽  
Ying Li ◽  
Laiya Lu ◽  
Cuijun Deng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Rat Model ◽  
Cell Labeling ◽  
Oxide Nanoparticles ◽  
Adipose Derived Stem Cells ◽  
Adipose Derived Stem Cell

The chitosan modified IO-CS nanoparticles are biocompatible and efficient MRI reagents for the adipose-derived stem cell labeling and tracking in an osteoarthritis rat model.

Bone marrow derived mesenchymal stem cell labeling using silica-coated superparamagnetic iron oxide nanoparticles: Effects of amine functional peripheries

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S94-S95 ◽  
Author(s):  
Yi-Xiang Wang ◽  
Hao-Hao Wang ◽  
Ken C.F. Leung ◽  
Ling Qin ◽  
Doris W.T. Au ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Iron Oxide ◽  
Mesenchymal Stem Cell ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Cell Labeling ◽  
Oxide Nanoparticles

Stem cell labeling with iron oxide nanoparticles: impact of 3D culture on cell labeling maintenance

Nanomedicine ◽  
2016 ◽  
Vol 11 (15) ◽  
pp. 1957-1970 ◽  
Author(s):  
Teresa Kilian ◽  
Florian Fidler ◽  
Annika Kasten ◽  
Sarah Nietzer ◽  
Veronika Landgraf ◽  
...  
Keyword(s):  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
3D Culture ◽  
Cell Labeling ◽  
Oxide Nanoparticles

Cancer stem cell labeling using poly(l-lysine)-modified iron oxide nanoparticles

Biomaterials ◽  
2012 ◽  
Vol 33 (14) ◽  
pp. 3719-3732 ◽  
Author(s):  
Xueqin Wang ◽  
Fang Wei ◽  
Ajing Liu ◽  
Lei Wang ◽  
Jian-Chun Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Iron Oxide ◽  
Cancer Stem Cell ◽  
Iron Oxide Nanoparticles ◽  
Cell Labeling ◽  
Oxide Nanoparticles

Monodispersed polymer encapsulated superparamagnetic iron oxide nanoparticles for cell labeling

Polymer ◽  
2016 ◽  
Vol 106 ◽  
pp. 238-248 ◽  
Author(s):  
Duc Nguyen ◽  
Binh T.T. Pham ◽  
Vien Huynh ◽  
Byung J. Kim ◽  
Nguyen T.H. Pham ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Cell Labeling ◽  
Oxide Nanoparticles
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