DNA Binding and Cleavage by a Cationic Manganese Porphyrin−Peptide Nucleic Acid Conjugate

1997 ◽  
Vol 8 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Pascal Bigey ◽  
Søren Holst Sönnichsen ◽  
Bernard Meunier ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Manganese Porphyrin ◽  
Acid Conjugate ◽  
Dna Binding And Cleavage

Synthesis and DNA Binding Property of a Novel Peptide Nucleic Acid that Containscis-4-Adeninyl-L-prolinol Unit

2001 ◽  
Vol 30 (7) ◽  
pp. 634-635 ◽  
Author(s):  
Masanori Shigeyasu ◽  
Masayasu Kuwahara ◽  
Masahiko Sisido ◽  
Teruhiko Ishikawa
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Binding Property ◽  
Dna Binding Property

scholarly journals Inducible Alkylation of DNA by a Quinone Methide–Peptide Nucleic Acid Conjugate

Biochemistry ◽  
2012 ◽  
Vol 51 (5) ◽  
pp. 1020-1027 ◽  
Author(s):  
Yang Liu ◽  
Steven E. Rokita
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Quinone Methide ◽  
Acid Conjugate

Direction control in DNA binding of chiral d-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry

2003 ◽  
pp. 1102-1103 ◽  
Author(s):  
Stefano Sforza ◽  
Tullia Tedeschi ◽  
Roberto Corradini ◽  
Arnaldo Dossena ◽  
Rosangela Marchelli
Keyword(s):  
Mass Spectrometry ◽  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Electrospray Mass Spectrometry ◽  
Direction Control

scholarly journals ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives

2017 ◽  
Vol 7 (2) ◽  
pp. 20160117 ◽  
Author(s):  
Kurt Hoogewijs ◽  
Andrew M. James ◽  
Robin A. J. Smith ◽  
Frank Abendroth ◽  
Michael J. Gait ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Click Chemistry ◽  
Peptide Nucleic Acid ◽  
Mitochondrial Matrix ◽  
Major Difficulty ◽  
Mitochondrial Membranes ◽  
Mitochondrial Import ◽  
Acid Conjugate ◽  
Multiple Molecules

There is an increasing interest in targeting molecules to the mitochondrial matrix. Many proteins are naturally imported through the translocase complexes found in the outer and inner mitochondrial membranes. One possible means for importing molecules is therefore to use a mitochondrial pre-protein as a vector and assess what forms of molecules can be attached to the pre-protein as cargo. A major difficulty with this approach is to ensure that any chimaeric molecule does indeed access the mitochondrial matrix and does not merely associate with the mitochondrial membranes. We have recently demonstrated that click chemistry can be used both to demonstrate convincingly mitochondrial import of a peptide–peptide nucleic acid conjugate and also to quantify the mitochondrial uptake for specific synthetic conjugates. We now report an adaptation of the synthesis to facilitate simple quantification of multiple molecules and hence to calculate the efficiency of their mitochondrial import.

Transition Metal Derivatives of Peptide Nucleic Acid (PNA) OligomersSynthesis, Characterization, and DNA Binding

2000 ◽  
Vol 11 (6) ◽  
pp. 741-743 ◽  
Author(s):  
Jeroen C. Verheijen ◽  
Gijs A. van der Marel ◽  
Jacques H. van Boom ◽  
Nils Metzler-Nolte
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Transition Metal ◽  
Peptide Nucleic Acid ◽  
Metal Derivatives ◽  
Derivatives Of

Activatable Cell Penetrating Peptide–Peptide Nucleic Acid Conjugate via Reduction of Azobenzene PEG Chains

2014 ◽  
Vol 136 (37) ◽  
pp. 12868-12871 ◽  
Author(s):  
Soo Hyeon Lee ◽  
Elena Moroz ◽  
Bastien Castagner ◽  
Jean-Christophe Leroux
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Acid Conjugate

Circular dichroism study of DNA binding by a potential anticancer peptide nucleic acid targeted against theMYCN oncogene

Chirality ◽  
2008 ◽  
Vol 20 (3-4) ◽  
pp. 494-500 ◽  
Author(s):  
Andrea Faccini ◽  
Andrea Tortori ◽  
Tullia Tedeschi ◽  
Stefano Sforza ◽  
Roberto Tonelli ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Anticancer Peptide ◽  
Circular Dichroïsm

Gene delivery by a steroid‐peptide nucleic acid conjugate

2002 ◽  
Vol 16 (11) ◽  
pp. 1426-1428 ◽  
Author(s):  
Alexandre G. Rebuffat ◽  
Andrea R. Nawrocki ◽  
Peter E. Nielsen ◽  
Alessio G. Bernasconi ◽  
Eloy Bernal‐Mendez ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Gene Delivery ◽  
Peptide Nucleic Acid ◽  
Acid Conjugate

The application of strand invasion phenomenon, directed by peptide nucleic acid (PNA) and single-stranded DNA binding protein (SSB) for the recognition of specific sequences of human endogenous retroviral HERV-W family

2016 ◽  
Vol 30 (5) ◽  
pp. e2600 ◽  
Author(s):  
Grzegorz Machnik ◽  
Łukasz Bułdak ◽  
Jarosław Ruczyński ◽  
Tomasz Gąsior ◽  
Małgorzata Huzarska ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Single Stranded Dna ◽  
Strand Invasion ◽  
Specific Sequences
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